HUMAN:SMAD4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMAD4 (synonyms: DPC4, MADH4)
Protein Name(s)	Mothers against decapentaplegic homolog 4 MAD homolog 4 Mothers against DPP homolog 4 Deletion target in pancreatic carcinoma 4 SMAD family member 4 SMAD 4 Smad4 hSMAD4
External Links
UniProt	Q13485
EMBL	AF045447 AF045438 AF045439 AF045440 AF045441 AF045442 AF045443 AF045444 AF045445 AF045446 U44378 AK290770 CH471096 BC002379
CCDS	CCDS11950.1
PIR	S71811
RefSeq	NP_005350.1
UniGene	Hs.75862
PDB	1DD1 1G88 1MR1 1U7F 1U7V 1YGS
PDBsum	1DD1 1G88 1MR1 1U7F 1U7V 1YGS
DisProt	DP00464
ProteinModelPortal	Q13485
SMR	Q13485
BioGrid	110264
DIP	DIP-31512N
IntAct	Q13485
MINT	MINT-244037
STRING	9606.ENSP00000341551
PhosphoSite	Q13485
BioMuta	SMAD4
DMDM	13959561
MaxQB	Q13485
PaxDb	Q13485
PeptideAtlas	Q13485
PRIDE	Q13485
DNASU	4089
Ensembl	ENST00000342988 ENST00000398417
GeneID	4089
KEGG	hsa:4089
UCSC	uc002lfb.4
CTD	4089
GeneCards	GC18P048494
GeneReviews	SMAD4
HGNC	HGNC:6770
HPA	CAB002312 HPA019154
MIM	114500 139210 174900 175050 260350 600993
neXtProt	NX_Q13485
Orphanet	1333 329971 774 2588
PharmGKB	PA30527
eggNOG	NOG286923
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286019
HOVERGEN	HBG053353
InParanoid	Q13485
KO	K04501
OMA	PTEGHSI
OrthoDB	EOG712TW5
PhylomeDB	Q13485
TreeFam	TF314923
Reactome	REACT_111057 REACT_12034 REACT_120734 REACT_120850 REACT_121111 REACT_150238 REACT_169107 REACT_169165 REACT_263856
SignaLink	Q13485
ChiTaRS	SMAD4
EvolutionaryTrace	Q13485
GeneWiki	Mothers_against_decapentaplegic_homolog_4
GenomeRNAi	4089
NextBio	16030
PRO	PR:Q13485
Proteomes	UP000005640
Bgee	Q13485
CleanEx	HS_SMAD4
ExpressionAtlas	Q13485
Genevisible	Q13485
GO	GO:0032444 GO:0005813 GO:0005737 GO:0005829 GO:0000790 GO:0005654 GO:0005634 GO:0071141 GO:0005667 GO:0003682 GO:0000987 GO:0070411 GO:0042802 GO:0046872 GO:0042803 GO:0070412 GO:0000978 GO:0001077 GO:0001076 GO:0044212 GO:0030616 GO:0036302 GO:0003190 GO:0007411 GO:0030509 GO:0003360 GO:0001658 GO:0003279 GO:0008283 GO:0048589 GO:0042733 GO:0060956 GO:0007492 GO:0042118 GO:0003198 GO:0048859 GO:0001702 GO:0010467 GO:0001701 GO:0035556 GO:0007498 GO:0072133 GO:0060548 GO:0030308 GO:0008285 GO:0042177 GO:0000122 GO:0045892 GO:0072134 GO:0014033 GO:0048663 GO:0060021 GO:0030513 GO:0003251 GO:0010718 GO:0010862 GO:0060391 GO:0045944 GO:0045893 GO:0030511 GO:0051098 GO:0051797 GO:0017015 GO:0032909 GO:0001666 GO:0071559 GO:0048733 GO:0007183 GO:0060395 GO:0035019 GO:0032525 GO:0006367 GO:0006351 GO:0007179
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035556	intracellular signal transduction	PMID:22316667^[1]	ECO:0000315			P		SMAD4 Mutations result in in disruption of BMP signaling. Using samples obtained from human JP samples, followed by PCR & SDM, mutants activity (as assayed by Luciferase, see Figure 1) was much lower then WT, confirming the hypothesis of mutated SMAD signaling being a key component of JP patients.	complete CACAO 3767
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:25514493^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	F		Seeded From UniProt	complete
involved_in	GO:0060956	endocardial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003190	atrioventricular valve formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97454	F		Seeded From UniProt	complete
involved_in	GO:1905305	negative regulation of cardiac myofibril assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10647180^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043199	sulfate binding	PMID:10647180^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	PMID:10647180^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:10647180^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	occurs_in:(UBERON:0001133) has_regulation_target:(UniProtKB:P12883)\|occurs_in(UBERON:0001133) has_regulation_target:(UniProtKB:P01160)\|occurs_in(UBERON:0001133) has_regulation_target:(UniProtKB:P16860)	Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	has_regulation_target:(UniProtKB:P81172) occurs_in:(UBERON:0002107)\|has_regulation_target(UniProtKB:P81172) part_of:(GO:0070102)\|has_regulation_target(UniProtKB:P81172) part_of:(GO:0030509) occurs_in:(CL:0000182)\|has_regulation_target(UniProtKB:P81172) part_of:(GO:0007179) occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:14687659^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	has_regulation_target:(UniProtKB:Q9NP59) occurs_in:(UBERON:0002114)\|has_regulation_target(UniProtKB:P49281) occurs_in:(UBERON:0002114)\|has_regulation_target(UniProtKB:Q53TN4) occurs_in:(UBERON:0002114)	Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:O15105)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P81172)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P41134)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q96SQ7)	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P22004)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16007207^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:22316667^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9732876^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9111321^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9111321^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9111321^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9311995^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9311995^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:8774881^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:9256479^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43541	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:9707553^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:9732876^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9732876^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9311995^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8774881^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8774881^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17438144^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:10823886^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8774881^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9111321^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	PMID:12411310^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:19366699^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:19328798^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:8774881^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	PMID:8774881^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	PMID:10823886^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:9732876^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9311995^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12161428^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17438144^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9311995^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12161428^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	PMID:17438144^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	PMID:10823886^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	PMID:9389648^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:12411310^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21828274^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000925)\|part_of:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0071559	response to transforming growth factor beta	PMID:9707553^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	PMID:18832382^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18832382^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9707553^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12374795^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8JIT7	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12374795^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70056	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:18832382^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:18832382^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:1905305	negative regulation of cardiac myofibril assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	C		Seeded From UniProt	complete
involved_in	GO:0072520	seminiferous tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0072134	nephrogenic mesenchyme morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0072133	metanephric mesenchyme morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0061040	female gonad morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0060956	endocardial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0051797	regulation of hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0051098	regulation of binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0048859	formation of anatomical boundary	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0048733	sebaceous gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0048729	tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
involved_in	GO:0046881	positive regulation of follicle-stimulating hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0033686	positive regulation of luteinizing hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0032525	somite rostral/caudal axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0014033	neural crest cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
involved_in	GO:0003360	brainstem development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003279	cardiac septum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003190	atrioventricular valve formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97471 ensembl:ENSMUSP00000025393	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	PMID:14687659^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173796	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	Reactome:R-HSA-452723	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173789	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-870479 Reactome:R-HSA-870477 Reactome:R-HSA-870437 Reactome:R-HSA-3315483 Reactome:R-HSA-3311014 Reactome:R-HSA-2106579 Reactome:R-HSA-2031355 Reactome:R-HSA-201472 Reactome:R-HSA-201422 Reactome:R-HSA-173488 Reactome:R-HSA-170847	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625758 Reactome:R-NUL-2186755 Reactome:R-NUL-2186736 Reactome:R-HSA-9618021 Reactome:R-HSA-9618004 Reactome:R-HSA-9617996 Reactome:R-HSA-8952226 Reactome:R-HSA-8878178 Reactome:R-HSA-8878143 Reactome:R-HSA-8878013 Reactome:R-HSA-8877941 Reactome:R-HSA-870538 Reactome:R-HSA-870477 Reactome:R-HSA-870449 Reactome:R-HSA-480204 Reactome:R-HSA-2187388 Reactome:R-HSA-2187330 Reactome:R-HSA-2187325 Reactome:R-HSA-2187309 Reactome:R-HSA-2186643 Reactome:R-HSA-2186607 Reactome:R-HSA-2179276 Reactome:R-HSA-2179274 Reactome:R-HSA-2176503 Reactome:R-HSA-2176502 Reactome:R-HSA-2176491 Reactome:R-HSA-2176475 Reactome:R-HSA-2127257 Reactome:R-HSA-2106579 Reactome:R-HSA-209055 Reactome:R-HSA-201472 Reactome:R-HSA-201425 Reactome:R-HSA-201423 Reactome:R-HSA-173545 Reactome:R-HSA-173488 Reactome:R-HSA-173481 Reactome:R-HSA-1535903 Reactome:R-HSA-1225919 Reactome:R-HSA-1112609	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173795	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Carr, JC et al. (2012) Germline mutations in SMAD4 disrupt bone morphogenetic protein signaling. J. Surg. Res. 174 211-4 PubMed GONUTS page
↑ Yang, Y et al. (2015) Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses. Biochim. Biophys. Acta 1849 270-81 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Qin, B et al. (1999) Crystal structure of a transcriptionally active Smad4 fragment. Structure 7 1493-503 PubMed GONUTS page
↑ ^5.0 ^5.1 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page
↑ Pavio, N et al. (2005) Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 24 6119-32 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Zhang, Y et al. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394 909-13 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Wu, RY et al. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17 2521-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Nakao, A et al. (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16 5353-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page
↑ Topper, JN et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 94 9314-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Shioda, T et al. (1998) Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. U.S.A. 95 9785-90 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Denissova, NG et al. (2000) Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. U.S.A. 97 6397-402 PubMed GONUTS page
↑ ^16.0 ^16.1 Zhang, H et al. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101 2253-60 PubMed GONUTS page
↑ Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page
↑ Fritzmann, J et al. (2009) A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 137 165-75 PubMed GONUTS page
↑ ^19.0 ^19.1 Li, C et al. (2002) Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J. Biol. Chem. 277 38399-408 PubMed GONUTS page
↑ Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page
↑ ^22.0 ^22.1 Inman, GJ & Hill, CS (2002) Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277 51008-16 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[PMID:22316667-1] 1.0 ^1.1 Carr, JC et al. (2012) Germline mutations in SMAD4 disrupt bone morphogenetic protein signaling. J. Surg. Res. 174 211-4 PubMed GONUTS page

[PMID:25514493-2] Yang, Y et al. (2015) Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses. Biochim. Biophys. Acta 1849 270-81 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:10647180-4] 4.0 ^4.1 ^4.2 ^4.3 Qin, B et al. (1999) Crystal structure of a transcriptionally active Smad4 fragment. Structure 7 1493-503 PubMed GONUTS page

[PMID:14687659-5] 5.0 ^5.1 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page

[PMID:16007207-6] Pavio, N et al. (2005) Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 24 6119-32 PubMed GONUTS page

[PMID:9389648-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page

[PMID:9732876-8] 8.0 ^8.1 ^8.2 ^8.3 Zhang, Y et al. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394 909-13 PubMed GONUTS page

[PMID:9111321-9] 9.0 ^9.1 ^9.2 ^9.3 Wu, RY et al. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17 2521-8 PubMed GONUTS page

[PMID:9311995-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Nakao, A et al. (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16 5353-62 PubMed GONUTS page

[PMID:8774881-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page

[PMID:9256479-12] Topper, JN et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 94 9314-9 PubMed GONUTS page

[PMID:9707553-13] 13.0 ^13.1 ^13.2 Shioda, T et al. (1998) Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. U.S.A. 95 9785-90 PubMed GONUTS page

[PMID:17438144-14] 14.0 ^14.1 ^14.2 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page

[PMID:10823886-15] 15.0 ^15.1 ^15.2 Denissova, NG et al. (2000) Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. U.S.A. 97 6397-402 PubMed GONUTS page

[PMID:12411310-16] 16.0 ^16.1 Zhang, H et al. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101 2253-60 PubMed GONUTS page

[PMID:19366699-17] Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page

[PMID:19328798-18] Fritzmann, J et al. (2009) A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 137 165-75 PubMed GONUTS page

[PMID:12161428-19] 19.0 ^19.1 Li, C et al. (2002) Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J. Biol. Chem. 277 38399-408 PubMed GONUTS page

[PMID:21828274-20] Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page

[PMID:18832382-21] 21.0 ^21.1 ^21.2 ^21.3 Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page

[PMID:12374795-22] 22.0 ^22.1 Inman, GJ & Hill, CS (2002) Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277 51008-16 PubMed GONUTS page

[PMID:25609649-23] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:21988832-24] Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

HUMAN:SMAD4

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools