MOUSE:SMAD1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad1 (synonyms: Madh1, Madr1)
Protein Name(s)	Mothers against decapentaplegic homolog 1 MAD homolog 1 Mothers against DPP homolog 1 Dwarfin-A Dwf-A Mothers-against-DPP-related 1 Mad-related protein 1 mMad1 SMAD family member 1 SMAD 1 Smad1
External Links
UniProt	P70340
EMBL	U58992 U74359 AF295768 AF295763 AF295764 AF295765 AF295766 AF295767 AK017583 AK054104 BC058693
CCDS	CCDS22437.1
RefSeq	NP_032565.2 XP_006530809.1
UniGene	Mm.223717
PDB	3KMP
PDBsum	3KMP
ProteinModelPortal	P70340
SMR	P70340
BioGrid	201274
IntAct	P70340
MINT	MINT-99213
PhosphoSite	P70340
MaxQB	P70340
PaxDb	P70340
PRIDE	P70340
Ensembl	ENSMUST00000066091
GeneID	17125
KEGG	mmu:17125
UCSC	uc009mip.2
CTD	4086
MGI	MGI:109452
eggNOG	NOG330956
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286018
HOVERGEN	HBG053353
InParanoid	P70340
KO	K04676
OMA	MTHDTSQ
OrthoDB	EOG7W1540
TreeFam	TF314923
Reactome	REACT_220505
ChiTaRS	Smad1
EvolutionaryTrace	P70340
NextBio	291304
PRO	PR:P70340
Proteomes	UP000000589
Bgee	P70340
CleanEx	MM_SMAD1
ExpressionAtlas	P70340
Genevestigator	P70340
GO	GO:0005737 GO:0005739 GO:0005637 GO:0005634 GO:0043234 GO:0005667 GO:0046872 GO:0046982 GO:0042803 GO:0000979 GO:0003700 GO:0030509 GO:0060348 GO:0060038 GO:0051216 GO:0071773 GO:0071407 GO:0009880 GO:0007276 GO:0030902 GO:0042592 GO:0006954 GO:0000165 GO:0001710 GO:0030901 GO:0008285 GO:0010656 GO:0002051 GO:0061036 GO:0050775 GO:0010628 GO:0045669 GO:0045944 GO:1901522 GO:0006468 GO:0006357 GO:0042493 GO:0010243 GO:0007183 GO:0006351 GO:0007179 GO:0001657 GO:0042060
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030509	BMP signaling pathway	PMID:11788714^[1]	ECO:0000314			P		It is shown by figure 3 through a direct assay that Smad1 binds to an area of the Dlx-3 homeodomain that is responsive to BMP-2 signaling.	complete CACAO 6363
	GO:0007398	ectoderm development	PMID:11788714^[1]	ECO:0000314			P		It is shown by figure 3 through a direct assay that Smad1 binds to a promoter on the homeodomain Dlx-3 which regulates patterning in the embryonic ectoderm	complete CACAO 6365
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:21145505^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000075EEC2_10090)	Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	PMID:21145505^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(RNAcentral:URS000075EEC2_10090)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23169531^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19252488^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P20722	P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:19252488^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P20722	P	occurs_in:(UBERON:0002107) part_of:(GO:0030509)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19252488^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19252488^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	PMID:20843790^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97454	P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:20843790^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97454	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:20843790^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97454	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12151307^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11160896^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12151307^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:14656760^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19103752^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061036	positive regulation of cartilage development	PMID:19251704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060348	bone development	PMID:19224984^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328787 MGI:MGI:1859993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060038	cardiac muscle cell proliferation	PMID:17350578^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060038	cardiac muscle cell proliferation	PMID:17350578^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051216	cartilage development	PMID:19224984^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328787 MGI:MGI:1859993	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21724602^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24211589^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1913438	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19251704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96429)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18997172^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16556916^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98495)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15557274^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96429)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15150273^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21724602^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042592	homeostatic process	PMID:15198985^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:15899870^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157982	P	results_in_development_of:(EMAPA:16916)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:15899870^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157982	P	results_in_development_of:(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19224984^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328787 MGI:MGI:1859993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:16604073^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107191 MGI:MGI:1916835 MGI:MGI:88177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:15198985^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:25100727^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:18622394^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3805956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15899870^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157982	P	regulates_o_occurs_in:(EMAPA:17262)\|regulates_o_occurs_in:(EMAPA:16976)\|regulates_o_occurs_in:(EMAPA:17072)\|regulates_o_occurs_in:(EMAPA:17259)\|regulates_o_occurs_in:(EMAPA:17260)\|regulates_o_occurs_in:(EMAPA:17261)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007276	gamete generation	PMID:15198985^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007183	SMAD protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18776146^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:14633973^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:12270938^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19103752^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:14633973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25100727^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19793887^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19103752^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16556916^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:98495)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14633973^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002051	osteoblast fate commitment	PMID:15150273^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001710	mesodermal cell fate commitment	PMID:16801560^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1919200	P	results_in_commitment_to:(CL:0000222)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18692037^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17525) has_participant:(MGI:MGI:2661061)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:15198985^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3030	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	P		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	C		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	P		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15797 ensembl:ENSP00000305769	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:12370310^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page
↑ ^2.0 ^2.1 Wang, J et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev. Cell 19 903-12 PubMed GONUTS page
↑ Hutchins, AP et al. (2013) Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells 31 269-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Cho, YD et al. (2010) The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J. Biol. Chem. 285 36369-76 PubMed GONUTS page
↑ ^6.0 ^6.1 Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page
↑ Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page
↑ Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page
↑ ^10.0 ^10.1 Lin, EA et al. (2009) miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J. Biol. Chem. 284 11326-35 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Retting, KN et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 136 1093-104 PubMed GONUTS page
↑ ^12.0 ^12.1 Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page
↑ ^13.0 ^13.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page
↑ Peng, Y et al. (2013) Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Biochem. Biophys. Res. Commun. 441 751-6 PubMed GONUTS page
↑ Truksa, J et al. (2009) Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 113 688-95 PubMed GONUTS page
↑ ^16.0 ^16.1 Yang, L et al. (2006) Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133 1575-85 PubMed GONUTS page
↑ Liu, CJ et al. (2005) The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J. Biol. Chem. 280 2788-96 PubMed GONUTS page
↑ ^18.0 ^18.1 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Aubin, J et al. (2004) In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 18 1482-94 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Hester, M et al. (2005) Smad1 and Smad8 function similarly in mammalian central nervous system development. Mol. Cell. Biol. 25 4683-92 PubMed GONUTS page
↑ Babitt, JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 531-9 PubMed GONUTS page
↑ ^23.0 ^23.1 Zhao, Y et al. (2014) C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J. Biol. Chem. 289 26441-50 PubMed GONUTS page
↑ Yamaji, M et al. (2008) Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat. Genet. 40 1016-22 PubMed GONUTS page
↑ Caubit, X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135 3301-10 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Xiao, C et al. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17 2933-49 PubMed GONUTS page
↑ Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page
↑ Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page
↑ Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page
↑ Jiao, K et al. (2002) Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Mol. Cell. Biol. 22 7633-44 PubMed GONUTS page

[PMID:11788714-1] 1.0 ^1.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page

[PMID:21145505-2] 2.0 ^2.1 Wang, J et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev. Cell 19 903-12 PubMed GONUTS page

[PMID:23169531-3] Hutchins, AP et al. (2013) Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells 31 269-81 PubMed GONUTS page

[PMID:19252488-4] 4.0 ^4.1 ^4.2 ^4.3 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page

[PMID:20843790-5] 5.0 ^5.1 ^5.2 Cho, YD et al. (2010) The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J. Biol. Chem. 285 36369-76 PubMed GONUTS page

[PMID:12151307-6] 6.0 ^6.1 Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page

[PMID:11160896-7] Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page

[PMID:14656760-8] Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page

[PMID:19103752-9] 9.0 ^9.1 ^9.2 Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page

[PMID:19251704-10] 10.0 ^10.1 Lin, EA et al. (2009) miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J. Biol. Chem. 284 11326-35 PubMed GONUTS page

[PMID:19224984-11] 11.0 ^11.1 ^11.2 Retting, KN et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 136 1093-104 PubMed GONUTS page

[PMID:17350578-12] 12.0 ^12.1 Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page

[PMID:21724602-13] 13.0 ^13.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page

[PMID:24211589-14] Peng, Y et al. (2013) Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Biochem. Biophys. Res. Commun. 441 751-6 PubMed GONUTS page

[PMID:18997172-15] Truksa, J et al. (2009) Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 113 688-95 PubMed GONUTS page

[PMID:16556916-16] 16.0 ^16.1 Yang, L et al. (2006) Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133 1575-85 PubMed GONUTS page

[PMID:15557274-17] Liu, CJ et al. (2005) The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J. Biol. Chem. 280 2788-96 PubMed GONUTS page

[PMID:15150273-18] 18.0 ^18.1 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page

[PMID:15198985-19] 19.0 ^19.1 ^19.2 ^19.3 Aubin, J et al. (2004) In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 18 1482-94 PubMed GONUTS page

[PMID:23610558-20] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:15899870-21] 21.0 ^21.1 ^21.2 Hester, M et al. (2005) Smad1 and Smad8 function similarly in mammalian central nervous system development. Mol. Cell. Biol. 25 4683-92 PubMed GONUTS page

[PMID:16604073-22] Babitt, JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 531-9 PubMed GONUTS page

[PMID:25100727-23] 23.0 ^23.1 Zhao, Y et al. (2014) C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J. Biol. Chem. 289 26441-50 PubMed GONUTS page

[PMID:18622394-24] Yamaji, M et al. (2008) Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat. Genet. 40 1016-22 PubMed GONUTS page

[PMID:18776146-25] Caubit, X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135 3301-10 PubMed GONUTS page

[PMID:14633973-26] 26.0 ^26.1 ^26.2 Xiao, C et al. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17 2933-49 PubMed GONUTS page

[PMID:12270938-27] Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page

[PMID:19796622-28] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:19793887-29] Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page

[PMID:16801560-30] Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page

[PMID:18692037-31] Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page

[PMID:12370310-32] Jiao, K et al. (2002) Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Mol. Cell. Biol. 22 7633-44 PubMed GONUTS page

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