DANRE:O57574

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	Bone genetic protein 4 (ECO:0000313 with EMBL:BAA24407.1) Bone morphogenetic protein 4 (ECO:0000313 with EMBL:AAC13302.1)
External Links
UniProt	O57574
EMBL	AF056336 BC078423 D49972
RefSeq	NP_571417.1
UniGene	Dr.567
SMR	O57574
STRING	7955.ENSDARP00000069635
GeneID	30612
KEGG	dre:30612
CTD	652
ZFIN	ZDB-GENE-980528-2059
HOVERGEN	HBG004860
KO	K04662
PhylomeDB	O57574
NextBio	20806975
GO	GO:0005576 GO:0061312 GO:0003303 GO:0060803 GO:0045165 GO:0035844 GO:0061371 GO:0007368 GO:0071910 GO:0035469 GO:0048264 GO:0048565 GO:0009953 GO:0035125 GO:0035162 GO:0040007 GO:0007507 GO:0003146 GO:0001947 GO:0001707 GO:0042664 GO:0060034 GO:0030903 GO:0008284 GO:0003342 GO:0048793
Gene3D	2.10.90.10
InterPro	IPR029034 IPR002405 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PRINTS	PR00669
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071910	determination of liver left/right asymmetry	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111121-14	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111121-14	P	Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	PMID:21896629^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0060803	BMP signaling pathway involved in mesodermal cell fate specification	PMID:18948415^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0060034	notochord cell differentiation	PMID:18948415^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18305125^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080919-1	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18305125^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050429-3	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:22609551^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050228-1	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:12601179^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050708-1 ZFIN:ZDB-MRPHLNO-050708-3	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:9409664^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:17395172^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:17395172^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:12879074^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-990415-181	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:12879074^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0042664	negative regulation of endodermal cell fate specification	PMID:16672336^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-000208-25 ZFIN:ZDB-GENE-980526-474	P	Seeded From UniProt	complete
involved_in	GO:0035844	cloaca development	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-46	P	Seeded From UniProt	complete
involved_in	GO:0035844	cloaca development	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-45	P	Seeded From UniProt	complete
involved_in	GO:0035844	cloaca development	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-44	P	Seeded From UniProt	complete
involved_in	GO:0035469	determination of pancreatic left/right asymmetry	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111121-14	P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	PMID:15572152^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050221-6	P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	PMID:16672337^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035125	embryonic anal fin morphogenesis	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-46	P	Seeded From UniProt	complete
involved_in	GO:0035125	embryonic anal fin morphogenesis	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-45	P	Seeded From UniProt	complete
involved_in	GO:0035125	embryonic anal fin morphogenesis	PMID:21937597^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111118-44	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:18948415^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:26341094^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:22031546^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130816-7	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18948415^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:14595833^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17395172^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17395172^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050228-1 ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0003342	proepicardium development	PMID:20413782^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080213-1	P	Seeded From UniProt	complete
involved_in	GO:0003303	BMP signaling pathway involved in heart jogging	PMID:9334285^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:18267096^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-020828-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18267096^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050228-1 ZFIN:ZDB-MRPHLNO-060930-5 ZFIN:ZDB-MRPHLNO-060930-6 ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:15240553^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95689 MGI:MGI:95690 PANTHER:PTN000218210 RGD:2211 UniProtKB:O95393 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page
↑ Smith, KA et al. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development 138 4193-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Esterberg, R et al. (2008) Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Development 135 3891-901 PubMed GONUTS page
↑ ^4.0 ^4.1 Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page
↑ Zeng, L & Childs, SJ (2012) The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Dev. Biol. 367 178-86 PubMed GONUTS page
↑ Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page
↑ Kishimoto, Y et al. (1997) The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development 124 4457-66 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page
↑ ^9.0 ^9.1 Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page
↑ Poulain, M et al. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development 133 2189-200 PubMed GONUTS page
↑ Leung, AY et al. (2005) Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev. Biol. 277 235-54 PubMed GONUTS page
↑ Gupta, S et al. (2006) BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development 133 2177-87 PubMed GONUTS page
↑ Marques, CL et al. (2016) Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives. Cell. Mol. Life Sci. 73 841-57 PubMed GONUTS page
↑ Zuniga, E et al. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development 138 5147-56 PubMed GONUTS page
↑ Shentu, H et al. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis 37 103-12 PubMed GONUTS page
↑ Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page
↑ ^17.0 ^17.1 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^18.0 ^18.1 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
↑ Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21937597-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page

[PMID:21896629-2] Smith, KA et al. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development 138 4193-8 PubMed GONUTS page

[PMID:18948415-3] 3.0 ^3.1 ^3.2 ^3.3 Esterberg, R et al. (2008) Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Development 135 3891-901 PubMed GONUTS page

[PMID:18305125-4] 4.0 ^4.1 Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page

[PMID:22609551-5] Zeng, L & Childs, SJ (2012) The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Dev. Biol. 367 178-86 PubMed GONUTS page

[PMID:12601179-6] Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page

[PMID:9409664-7] Kishimoto, Y et al. (1997) The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development 124 4457-66 PubMed GONUTS page

[PMID:17395172-8] 8.0 ^8.1 ^8.2 ^8.3 Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page

[PMID:12879074-9] 9.0 ^9.1 Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page

[PMID:16672336-10] Poulain, M et al. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development 133 2189-200 PubMed GONUTS page

[PMID:15572152-11] Leung, AY et al. (2005) Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev. Biol. 277 235-54 PubMed GONUTS page

[PMID:16672337-12] Gupta, S et al. (2006) BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development 133 2177-87 PubMed GONUTS page

[PMID:26341094-13] Marques, CL et al. (2016) Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives. Cell. Mol. Life Sci. 73 841-57 PubMed GONUTS page

[PMID:22031546-14] Zuniga, E et al. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development 138 5147-56 PubMed GONUTS page

[PMID:14595833-15] Shentu, H et al. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis 37 103-12 PubMed GONUTS page

[PMID:20413782-16] Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page

[PMID:9334285-17] 17.0 ^17.1 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:18267096-18] 18.0 ^18.1 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page

[PMID:15240553-19] Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:O57574

Contents

Annotations

Notes

References

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