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DANRE:O57574

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) Bone genetic protein 4 (ECO:0000313 with EMBL:BAA24407.1)

Bone morphogenetic protein 4 (ECO:0000313 with EMBL:AAC13302.1)

External Links
UniProt O57574
EMBL AF056336
BC078423
D49972
RefSeq NP_571417.1
UniGene Dr.567
SMR O57574
STRING 7955.ENSDARP00000069635
GeneID 30612
KEGG dre:30612
CTD 652
ZFIN ZDB-GENE-980528-2059
HOVERGEN HBG004860
KO K04662
PhylomeDB O57574
NextBio 20806975
GO GO:0005576
GO:0061312
GO:0003303
GO:0060803
GO:0045165
GO:0035844
GO:0061371
GO:0007368
GO:0071910
GO:0035469
GO:0048264
GO:0048565
GO:0009953
GO:0035125
GO:0035162
GO:0040007
GO:0007507
GO:0003146
GO:0001947
GO:0001707
GO:0042664
GO:0060034
GO:0030903
GO:0008284
GO:0003342
GO:0048793
Gene3D 2.10.90.10
InterPro IPR029034
IPR002405
IPR001839
IPR001111
IPR015615
IPR017948
PANTHER PTHR11848
Pfam PF00019
PF00688
PRINTS PR00669
SMART SM00204
SUPFAM SSF57501
PROSITE PS00250
PS51362

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000747027

P

Seeded From UniProt

complete

GO:0001707

mesoderm formation

PMID:15240553[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:18267096[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050228-1
ZFIN:ZDB-MRPHLNO-060930-5
ZFIN:ZDB-MRPHLNO-060930-6
ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:18267096[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-020828-1

P

Seeded From UniProt

complete

GO:0003303

BMP signaling pathway involved in heart jogging

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003342

proepicardium development

PMID:20413782[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080213-1

P

Seeded From UniProt

complete

GO:0005125

cytokine activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

F

Seeded From UniProt

complete

GO:0005160

transforming growth factor beta receptor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

F

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002405

C

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

C

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17395172[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050228-1
ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17395172[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0007507

heart development

PMID:14595833[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001111
InterPro:IPR001839
InterPro:IPR017948

F

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

GO:0008284

positive regulation of cell proliferation

PMID:18948415[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:22031546[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130816-7

P

Seeded From UniProt

complete

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:18948415[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0035125

embryonic anal fin morphogenesis

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-44

P

Seeded From UniProt

complete

GO:0035125

embryonic anal fin morphogenesis

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-45

P

Seeded From UniProt

complete

GO:0035125

embryonic anal fin morphogenesis

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-46

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:15572152[10]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050221-6

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:16672337[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035469

determination of pancreatic left/right asymmetry

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111121-14

P

Seeded From UniProt

complete

GO:0035844

cloaca development

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-44

P

Seeded From UniProt

complete

GO:0035844

cloaca development

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-45

P

Seeded From UniProt

complete

GO:0035844

cloaca development

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111118-46

P

Seeded From UniProt

complete

GO:0040007

growth

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001111

P

Seeded From UniProt

complete

GO:0042664

negative regulation of endodermal cell fate specification

PMID:16672336[12]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-000208-25
ZFIN:ZDB-GENE-980526-474

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000747027

P

Seeded From UniProt

complete

GO:0043408

regulation of MAPK cascade

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

P

Seeded From UniProt

complete

GO:0045165

cell fate commitment

PMID:12879074[13]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

GO:0045165

cell fate commitment

PMID:12879074[13]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-990415-181

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:12601179[14]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050708-1
ZFIN:ZDB-MRPHLNO-050708-3

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:17395172[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:17395172[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:9409664[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048468

cell development

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

P

Seeded From UniProt

complete

GO:0048565

digestive tract development

PMID:22609551[16]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050228-1

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:18305125[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050429-3

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:18305125[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080919-1

P

Seeded From UniProt

complete

GO:0060034

notochord cell differentiation

PMID:18948415[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0060395

SMAD protein signal transduction

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000218063

P

Seeded From UniProt

complete

GO:0060803

BMP signaling pathway involved in mesodermal cell fate specification

PMID:18948415[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0061312

BMP signaling pathway involved in heart development

PMID:21896629[18]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0061371

determination of heart left/right asymmetry

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111121-14

P

Seeded From UniProt

complete

GO:0070700

BMP receptor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000747027

F

Seeded From UniProt

complete

GO:0071910

determination of liver left/right asymmetry

PMID:21937597[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111121-14

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page
  2. 2.0 2.1 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
  3. 3.0 3.1 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
  4. Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page
  6. Shentu, H et al. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis 37 103-12 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Esterberg, R et al. (2008) Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Development 135 3891-901 PubMed GONUTS page
  8. Zuniga, E et al. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development 138 5147-56 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page
  10. Leung, AY et al. (2005) Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev. Biol. 277 235-54 PubMed GONUTS page
  11. Gupta, S et al. (2006) BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development 133 2177-87 PubMed GONUTS page
  12. Poulain, M et al. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development 133 2189-200 PubMed GONUTS page
  13. 13.0 13.1 Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page
  14. Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page
  15. Kishimoto, Y et al. (1997) The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development 124 4457-66 PubMed GONUTS page
  16. Zeng, L & Childs, SJ (2012) The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Dev. Biol. 367 178-86 PubMed GONUTS page
  17. 17.0 17.1 Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page
  18. Smith, KA et al. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development 138 4193-8 PubMed GONUTS page