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PMID:16672337
| Citation |
Gupta, S, Zhu, H, Zon, LI and Evans, T (2006) BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development 133:2177-87 |
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| Abstract |
The bone morphogenetic protein (BMP) signaling pathway is essential during gastrulation for the generation of ventral mesoderm, which makes it a challenge to define functions for this pathway at later stages of development. We have established an approach to disrupt BMP signaling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embryos. This results in expansion of hematopoietic and endothelial cells, while restricting the expression domain of the pronephric marker pax2.1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development. The results show that the BMP signaling pathway continues to function after cells are committed to a lateral mesoderm fate, and influences subsequent lineage decisions by restricting hemato-vascular fate in favor of pronephric development. |
| Links |
PubMed Online version:10.1242/dev.02386 |
| Keywords |
Animals; Animals, Genetically Modified; Biological Markers; Bone Morphogenetic Protein Receptors/genetics; Bone Morphogenetic Protein Receptors/metabolism; Bone Morphogenetic Proteins/metabolism; Deoxyribonucleases, Type II Site-Specific/genetics; Deoxyribonucleases, Type II Site-Specific/metabolism; Gene Expression Regulation, Developmental; Hematopoiesis; Kidney/blood supply; Kidney/embryology; Kidney/metabolism; Mesoderm/metabolism; PAX2 Transcription Factor/metabolism; Saccharomyces cerevisiae Proteins; Signal Transduction; Somites/metabolism; Stem Cells/metabolism; Time Factors; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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