HUMAN:JUN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	JUN
Protein Name(s)	Transcription factor AP-1 Activator protein 1 AP1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog p39
External Links
UniProt	P05412
EMBL	J04111 CR541724 BT019759 AY217548 AL136985 BC002646 BC006175 BC009874 BC068522
CCDS	CCDS610.1
PIR	A31264
RefSeq	NP_002219.1
UniGene	Hs.696684
PDB	1A02 1FOS 1JNM 1JUN 1S9K 1T2K
PDBsum	1A02 1FOS 1JNM 1JUN 1S9K 1T2K
ProteinModelPortal	P05412
SMR	P05412
BioGrid	109928
DIP	DIP-5961N
IntAct	P05412
MINT	MINT-105756
STRING	9606.ENSP00000360266
BindingDB	P05412
ChEMBL	CHEMBL2111421
DrugBank	DB01169 DB01029 DB00852 DB00570
PhosphoSite	P05412
DMDM	135298
MaxQB	P05412
PaxDb	P05412
PRIDE	P05412
DNASU	3725
Ensembl	ENST00000371222
GeneID	3725
KEGG	hsa:3725
UCSC	uc001cze.3
CTD	3725
GeneCards	GC01M059246
H-InvDB	HIX0000635
HGNC	HGNC:6204
HPA	CAB003801 CAB007780
MIM	165160
neXtProt	NX_P05412
PharmGKB	PA30006
eggNOG	NOG283376
GeneTree	ENSGT00390000009929
HOGENOM	HOG000006648
HOVERGEN	HBG001722
InParanoid	P05412
KO	K04448
OMA	AELHNQN
OrthoDB	EOG75MVXV
PhylomeDB	P05412
TreeFam	TF323952
Reactome	REACT_118568 REACT_163701 REACT_169168 REACT_169436 REACT_21326
SignaLink	P05412
ChiTaRS	JUN
EvolutionaryTrace	P05412
GeneWiki	C-jun
GenomeRNAi	3725
NextBio	14583
PRO	PR:P05412
Proteomes	UP000005640
Bgee	P05412
CleanEx	HS_JUN
Genevestigator	P05412
GO	GO:0005829 GO:0000228 GO:0005719 GO:0005654 GO:0005634 GO:0005667 GO:0017053 GO:0035497 GO:0003677 GO:0003690 GO:0019899 GO:0044822 GO:0070412 GO:0005100 GO:0001102 GO:0001077 GO:0000980 GO:0003705 GO:0001190 GO:0000981 GO:0003700 GO:0003713 GO:0008134 GO:0044212 GO:0007568 GO:0001525 GO:0031103 GO:0071277 GO:0051365 GO:0007623 GO:0038095 GO:0045087 GO:0035026 GO:0007612 GO:0001889 GO:0051899 GO:0001774 GO:0030224 GO:0002755 GO:0002756 GO:0043922 GO:0008285 GO:0043392 GO:0043524 GO:0031953 GO:1990441 GO:0045892 GO:0003151 GO:0043923 GO:0045740 GO:0001938 GO:0048146 GO:0045657 GO:0043525 GO:0032321 GO:0048661 GO:0045944 GO:0045893 GO:0051726 GO:0051090 GO:0001836 GO:0051591 GO:0034097 GO:0042493 GO:0042542 GO:0032496 GO:0009612 GO:0009314 GO:0007184 GO:0060395 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0007179 GO:0035666
Gene3D	1.10.880.10
InterPro	IPR004827 IPR015558 IPR005643 IPR002112 IPR008917
PANTHER	PTHR11462:SF8
Pfam	PF00170 PF03957
PRINTS	PR00043
SMART	SM00338
SUPFAM	SSF47454
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000144	positive regulation of DNA-dependent transcription, initiation	PMID:23027619^[1]	ECO:0000314			P		Measured through luciferase activity, Figure 3C clearly shows that transfection of c-Jun leads to nearly a 3 fold increase in the transcription of IL-11.	complete CACAO 7693
enables	GO:0044389	ubiquitin-like protein ligase binding	PMID:27458189^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002112 InterPro:IPR004827 InterPro:IPR008917 InterPro:IPR015558	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:22083952^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:22083952^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P09450	F		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:28701355^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:26514923^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:26514923^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035976	transcription factor AP-1 complex	PMID:26514923^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:26514923^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:10508860^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035976	transcription factor AP-1 complex	PMID:10508860^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10508860^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10508860^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10508860^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:10508860^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01100	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12490281^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:2729)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:14739464^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62877	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:24623306^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:24623306^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:24375836^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000075DE64_9606)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19962668^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000270069) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:19962668^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000270069)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17325	P		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	PMID:23027619^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21113145^[13]	ECO:0000305	curator inference used in manual assertion	GO:0044212 GO:1990441	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21113145^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:21113145^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21113145^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9732876^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:9732876^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9732876^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9732876^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035497	cAMP response element binding	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16007074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NQB0	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:9732876^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9732876^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:19861239^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15336	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:19861239^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[19]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:14645924^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043923	positive regulation by host of viral transcription	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043922	negative regulation by host of viral transcription	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:14645924^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:11804590^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:2833704^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96646 MGI:MGI:96647 PANTHER:PTN000894785	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784 RGD:2943 UniProtKB:A0A1D8PIL5 UniProtKB:P05412 UniProtKB:P17275 UniProtKB:P17535	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96647 PANTHER:PTN000894785	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96646 PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2945	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944 RGD:2945	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96648 PANTHER:PTN000894785 RGD:2943 UniProtKB:P05412 WB:WBGene00012005	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 PANTHER:PTN000894784 ZFIN:ZDB-GENE-030131-7859	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 UniProtKB:P05412 UniProtKB:P17275	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 UniProtKB:P05412	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 PANTHER:PTN000894784	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 SGD:S000000735	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05412	F	occurs_in:(GO:0000785)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20102225^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05412	F	occurs_in:(GO:0000785)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0035026	leading edge cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0031953	negative regulation of protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	C		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0009987	cellular process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	F		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05627 ensembl:ENSMUSP00000102711	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0051365	cellular response to potassium ion starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0045657	positive regulation of monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17325 ensembl:ENSRNOP00000011732	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR008917 InterPro:IPR015558	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR004827 InterPro:IPR015558	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR004827 InterPro:IPR008917 InterPro:IPR015558	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:2825349^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:10918580^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	Reactome:R-HSA-450341	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9009371 Reactome:R-HSA-8944047 Reactome:R-HSA-6806412 Reactome:R-HSA-5692761 Reactome:R-HSA-4568737 Reactome:R-HSA-450292 Reactome:R-HSA-3797196 Reactome:R-HSA-3222533 Reactome:R-HSA-168440 Reactome:R-HSA-168136	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shin, SY et al. (2012) Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Carcinogenesis 33 2467-76 PubMed GONUTS page
↑ Kravchick, DO et al. (2016) Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. EMBO J. 35 1923-34 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Ji, Z et al. (2012) The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. Mol. Cell. Biol. 32 385-98 PubMed GONUTS page
↑ Qian, Z et al. (2017) miR-4632 mediates PDGF-BB-induced proliferation and antiapoptosis of human pulmonary artery smooth muscle cells via targeting cJUN. Am. J. Physiol., Cell Physiol. 313 C380-C391 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Imafuku, I et al. (1999) Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147 121-34 PubMed GONUTS page
↑ Marini, MG et al. () Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Blood Cells Mol. Dis. 29 145-58 PubMed GONUTS page
↑ Wertz, IE et al. (2004) Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303 1371-4 PubMed GONUTS page
↑ ^10.0 ^10.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
↑ Lv, XB et al. (2014) MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim. Cell Biol. Int. 38 435-43 PubMed GONUTS page
↑ ^12.0 ^12.1 Garofalo, M et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16 498-509 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page
↑ Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Zhang, Y et al. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394 909-13 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page
↑ Nateri, AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437 281-5 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Mermod, N et al. (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332 557-61 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ ^20.0 ^20.1 Glahder, JA et al. (2003) A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA. J. Gen. Virol. 84 3429-41 PubMed GONUTS page
↑ Miura, K et al. (2002) ARAP1: a point of convergence for Arf and Rho signaling. Mol. Cell 9 109-19 PubMed GONUTS page
↑ ^22.00 ^22.01 ^22.02 ^22.03 ^22.04 ^22.05 ^22.06 ^22.07 ^22.08 ^22.09 ^22.10 ^22.11 ^22.12 ^22.13 ^22.14 ^22.15 ^22.16 ^22.17 ^22.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page
↑ Bohmann, D et al. (1987) Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238 1386-92 PubMed GONUTS page
↑ Finzer, P et al. (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. Oncogene 19 3235-44 PubMed GONUTS page

[PMID:23027619-1] 1.0 ^1.1 Shin, SY et al. (2012) Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Carcinogenesis 33 2467-76 PubMed GONUTS page

[PMID:27458189-2] Kravchick, DO et al. (2016) Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. EMBO J. 35 1923-34 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:22083952-4] 4.0 ^4.1 Ji, Z et al. (2012) The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. Mol. Cell. Biol. 32 385-98 PubMed GONUTS page

[PMID:28701355-5] Qian, Z et al. (2017) miR-4632 mediates PDGF-BB-induced proliferation and antiapoptosis of human pulmonary artery smooth muscle cells via targeting cJUN. Am. J. Physiol., Cell Physiol. 313 C380-C391 PubMed GONUTS page

[PMID:26514923-6] 6.0 ^6.1 ^6.2 ^6.3 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page

[PMID:10508860-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Imafuku, I et al. (1999) Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147 121-34 PubMed GONUTS page

[PMID:12490281-8] Marini, MG et al. () Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Blood Cells Mol. Dis. 29 145-58 PubMed GONUTS page

[PMID:14739464-9] Wertz, IE et al. (2004) Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303 1371-4 PubMed GONUTS page

[PMID:24623306-10] 10.0 ^10.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page

[PMID:24375836-11] Lv, XB et al. (2014) MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim. Cell Biol. Int. 38 435-43 PubMed GONUTS page

[PMID:19962668-12] 12.0 ^12.1 Garofalo, M et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16 498-509 PubMed GONUTS page

[PMID:21113145-13] 13.0 ^13.1 ^13.2 ^13.3 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page

[PMID:23382074-14] Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page

[PMID:9732876-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Zhang, Y et al. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394 909-13 PubMed GONUTS page

[PMID:19861239-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page

[PMID:16007074-17] Nateri, AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437 281-5 PubMed GONUTS page

[PMID:2833704-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Mermod, N et al. (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332 557-61 PubMed GONUTS page

[PMID:22681889-19] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:14645924-20] 20.0 ^20.1 Glahder, JA et al. (2003) A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA. J. Gen. Virol. 84 3429-41 PubMed GONUTS page

[PMID:11804590-21] Miura, K et al. (2002) ARAP1: a point of convergence for Arf and Rho signaling. Mol. Cell 9 109-19 PubMed GONUTS page

[PMID:21873635-22] 22.00 ^22.01 ^22.02 ^22.03 ^22.04 ^22.05 ^22.06 ^22.07 ^22.08 ^22.09 ^22.10 ^22.11 ^22.12 ^22.13 ^22.14 ^22.15 ^22.16 ^22.17 ^22.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25609649-23] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:20102225-24] Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page

[PMID:2825349-25] Bohmann, D et al. (1987) Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238 1386-92 PubMed GONUTS page

[PMID:10918580-26] Finzer, P et al. (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. Oncogene 19 3235-44 PubMed GONUTS page

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HUMAN:JUN

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