MOUSE:SMAD2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad2 (synonyms: Madh2, Madr2)
Protein Name(s)	Mothers against decapentaplegic homolog 2 MAD homolog 2 Mothers against DPP homolog 2 Mad-related protein 2 mMad2 SMAD family member 2 SMAD 2 Smad2
External Links
UniProt	Q62432
EMBL	U60530 AF005743 AK007817 AY334552 BC021342 BC089184
CCDS	CCDS29350.1
RefSeq	NP_001239410.1 NP_034884.2 XP_006525762.1 XP_006525763.1
UniGene	Mm.152699 Mm.490934
ProteinModelPortal	Q62432
SMR	Q62432
BioGrid	201275
IntAct	Q62432
MINT	MINT-99148
PhosphoSite	Q62432
MaxQB	Q62432
PaxDb	Q62432
PRIDE	Q62432
Ensembl	ENSMUST00000025453 ENSMUST00000091831 ENSMUST00000168423
GeneID	17126
KEGG	mmu:17126
UCSC	uc008fqn.2 uc008fqo.2
CTD	4087
MGI	MGI:108051
eggNOG	NOG320700
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286018
HOVERGEN	HBG053353
InParanoid	Q62432
KO	K04500
OMA	SYPDQTR
OrthoDB	EOG7W1540
PhylomeDB	Q62432
TreeFam	TF314923
Reactome	REACT_202264 REACT_203510 REACT_203903 REACT_215733 REACT_216222 REACT_216258 REACT_216792 REACT_217958 REACT_220566 REACT_220645 REACT_224802
ChiTaRS	Smad2
NextBio	291308
PRO	PR:Q62432
Proteomes	UP000000589
Bgee	Q62432
CleanEx	MM_SMAD2
ExpressionAtlas	Q62432
Genevestigator	Q62432
GO	GO:0032444 GO:0005737 GO:0000790 GO:0005634 GO:0071144 GO:0005667 GO:0003682 GO:0003690 GO:0046872 GO:0046982 GO:0042803 GO:0003700 GO:0046332 GO:0008134 GO:0030618 GO:0009952 GO:0045165 GO:0007182 GO:0048589 GO:0048701 GO:0048617 GO:0009880 GO:0007492 GO:0001706 GO:0007369 GO:0007507 GO:0001701 GO:0030073 GO:0035556 GO:0030324 GO:0001707 GO:0008285 GO:0010629 GO:0045892 GO:0038092 GO:0035265 GO:0060021 GO:0031016 GO:0048340 GO:0007389 GO:0060039 GO:0030513 GO:0010718 GO:0010628 GO:1900224 GO:0045944 GO:0045893 GO:0009791 GO:0006468 GO:0051098 GO:0017015 GO:0070723 GO:0009749 GO:0023019 GO:0007183 GO:0060395 GO:0006351 GO:0007179 GO:0001657 GO:0007352
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:24964035^[1]	ECO:0000353	physical interaction evidence used in manual assertion	ENSEMBL_GeneID:ENSG00000127445	F	has_input:(ENSEMBL:ENSMUSG00000032171) occurs_at:(SO:0000170)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:24964035^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24964035^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24964035^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	PMID:14691138^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14691138^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:14691138^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14691138^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14691138^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:11160896^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60929	F	occurs_in:(CL:0000515)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:9702197^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88621	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11937490^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B7ZQJ9	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11160896^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:14656760^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
part_of	GO:0071144	heteromeric SMAD protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070723	response to cholesterol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	PMID:23390484^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060039	pericardium development	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051098	regulation of binding	PMID:15282343^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048340	paraxial mesoderm morphogenesis	PMID:15084457^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21724602^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23390484^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17568773^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347465 MGI:MGI:98725	P	has_regulation_target:(MGI:MGI:1351322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17159989^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674 MGI:MGI:1314872 MGI:MGI:894293 MGI:MGI:98727	P	has_regulation_target:(MGI:MGI:3616404)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9702197^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15282343^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:12842913^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668416	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21724602^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038092	nodal signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:14749725^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035265	organ growth	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032924	activin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P	results_in_development_of:(EMAPA:18816)	Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030325	adrenal gland development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030073	insulin secretion	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P	occurs_in:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:23152446^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:23152446^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:9529255^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:12842913^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:11418863^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P	has_participant:(EMAPA:16332)\|has_participant:(EMAPA:35690)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:17849440^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007369	gastrulation	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007352	zygotic specification of dorsal/ventral axis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007183	SMAD protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007182	common-partner SMAD protein phosphorylation	PMID:16806156^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:18212064^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293 MGI:MGI:98725 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:14749725^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11557747^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18990706^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9702197^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17568773^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21300867^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16797) part_of:(CL:0000101)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3031	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:15282343^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16619037^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15657445^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:87951)	Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:15084457^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001706	endoderm formation	PMID:21822279^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:15183723^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17849440^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857692	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15796	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	C		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70436 ensembl:ENSRNOP00000075341	C		Seeded From UniProt	complete
involved_in	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
part_of	GO:0071144	heteromeric SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0038092	nodal signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
involved_in	GO:0007352	zygotic specification of dorsal/ventral axis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0007182	common-partner SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15796 ensembl:ENSP00000262160	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625492	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ueberham, U et al. (2014) Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 40 815-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nawshad, A & Hay, ED (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163 1291-301 PubMed GONUTS page
↑ ^3.0 ^3.1 Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
↑ Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page
↑ Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page
↑ ^7.0 ^7.1 Redshaw, N et al. (2013) TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. PLoS ONE 8 e55186 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Liu, Y et al. (2004) Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev. Biol. 270 411-26 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Dunn, NR et al. (2004) Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development 131 1717-28 PubMed GONUTS page
↑ ^11.0 ^11.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page
↑ ^12.0 ^12.1 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page
↑ Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page
↑ ^14.0 ^14.1 Vincent, SD et al. (2003) Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 17 1646-62 PubMed GONUTS page
↑ ^15.0 ^15.1 Maeda, S et al. (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23 552-63 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Goto, Y et al. (2007) Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev. Dyn. 236 2865-74 PubMed GONUTS page
↑ ^17.0 ^17.1 Colas, AR et al. (2012) Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 26 2567-79 PubMed GONUTS page
↑ Waldrip, WR et al. (1998) Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92 797-808 PubMed GONUTS page
↑ Brennan, J et al. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411 965-9 PubMed GONUTS page
↑ Dudas, M et al. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev. Biol. 296 298-314 PubMed GONUTS page
↑ Wilkinson, DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol. Cell. Biol. 28 1988-98 PubMed GONUTS page
↑ Ito, Y et al. (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J. Biol. Chem. 276 44163-72 PubMed GONUTS page
↑ Li, M et al. (2008) Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J. Biol. Chem. 283 36257-64 PubMed GONUTS page
↑ da Silva, S et al. (2011) Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A. 108 3395-400 PubMed GONUTS page
↑ Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page
↑ Wilkinson, DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol. Cell. Biol. 25 1200-12 PubMed GONUTS page
↑ Costello, I et al. (2011) The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat. Cell Biol. 13 1084-91 PubMed GONUTS page

[PMID:24964035-1] 1.0 ^1.1 ^1.2 ^1.3 Ueberham, U et al. (2014) Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 40 815-32 PubMed GONUTS page

[PMID:14691138-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nawshad, A & Hay, ED (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163 1291-301 PubMed GONUTS page

[PMID:11160896-3] 3.0 ^3.1 Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page

[PMID:9702197-4] 4.0 ^4.1 ^4.2 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page

[PMID:11937490-5] Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page

[PMID:14656760-6] Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page

[PMID:23390484-7] 7.0 ^7.1 Redshaw, N et al. (2013) TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. PLoS ONE 8 e55186 PubMed GONUTS page

[PMID:15183723-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Liu, Y et al. (2004) Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev. Biol. 270 411-26 PubMed GONUTS page

[PMID:15282343-9] 9.0 ^9.1 ^9.2 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page

[PMID:15084457-10] 10.0 ^10.1 Dunn, NR et al. (2004) Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development 131 1717-28 PubMed GONUTS page

[PMID:21724602-11] 11.0 ^11.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page

[PMID:17568773-12] 12.0 ^12.1 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page

[PMID:17159989-13] Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page

[PMID:12842913-14] 14.0 ^14.1 Vincent, SD et al. (2003) Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 17 1646-62 PubMed GONUTS page

[PMID:14749725-15] 15.0 ^15.1 Maeda, S et al. (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23 552-63 PubMed GONUTS page

[PMID:17849440-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Goto, Y et al. (2007) Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev. Dyn. 236 2865-74 PubMed GONUTS page

[PMID:23152446-17] 17.0 ^17.1 Colas, AR et al. (2012) Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 26 2567-79 PubMed GONUTS page

[PMID:9529255-18] Waldrip, WR et al. (1998) Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92 797-808 PubMed GONUTS page

[PMID:11418863-19] Brennan, J et al. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411 965-9 PubMed GONUTS page

[PMID:16806156-20] Dudas, M et al. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev. Biol. 296 298-314 PubMed GONUTS page

[PMID:18212064-21] Wilkinson, DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol. Cell. Biol. 28 1988-98 PubMed GONUTS page

[PMID:11557747-22] Ito, Y et al. (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J. Biol. Chem. 276 44163-72 PubMed GONUTS page

[PMID:18990706-23] Li, M et al. (2008) Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J. Biol. Chem. 283 36257-64 PubMed GONUTS page

[PMID:21300867-24] Silva, S et al. (2011) Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A. 108 3395-400 PubMed GONUTS page

[PMID:16619037-25] Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page

[PMID:15657445-26] Wilkinson, DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol. Cell. Biol. 25 1200-12 PubMed GONUTS page

[PMID:21822279-27] Costello, I et al. (2011) The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat. Cell Biol. 13 1084-91 PubMed GONUTS page

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MOUSE:SMAD2

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