MOUSE:HIPK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hipk2 (synonyms: Nbak1, Stank)
Protein Name(s)	Homeodomain-interacting protein kinase 2 Nuclear body-associated kinase 1 Sialophorin tail-associated nuclear serine/threonine-protein kinase
External Links
UniProt	Q9QZR5
EMBL	AF077659 AF273680 AF208292 AF333791 AF333792 AF170301 AF170302 AK016742 AK019821
CCDS	CCDS20017.2
PIR	T17088
RefSeq	NP_001129537.1 NP_001281072.1 NP_001281073.1 NP_034563.2
UniGene	Mm.23790 Mm.391962 Mm.486937
ProteinModelPortal	Q9QZR5
SMR	Q9QZR5
BioGrid	200307
DIP	DIP-31712N
IntAct	Q9QZR5
STRING	10090.ENSMUSP00000045457
PhosphoSite	Q9QZR5
MaxQB	Q9QZR5
PaxDb	Q9QZR5
PRIDE	Q9QZR5
Ensembl	ENSMUST00000160360 ENSMUST00000160962 ENSMUST00000161779 ENSMUST00000162359
GeneID	15258
KEGG	mmu:15258
UCSC	uc009bkw.2 uc009bkx.2 uc009blb.2
CTD	28996
MGI	MGI:1314872
eggNOG	COG0515
GeneTree	ENSGT00760000119032
HOVERGEN	HBG051908
InParanoid	Q9QZR5
KO	K08826
OMA	YSFPHNS
OrthoDB	EOG7034GK
PhylomeDB	Q9QZR5
TreeFam	TF105417
BRENDA	2.7.11.1
Reactome	REACT_196516
ChiTaRS	Hipk2
NextBio	287877
PRO	PR:Q9QZR5
Proteomes	UP000000589
Bgee	Q9QZR5
CleanEx	MM_HIPK2
ExpressionAtlas	Q9QZR5
Genevestigator	Q9QZR5
GO	GO:0005737 GO:0005634 GO:0016605 GO:0005524 GO:0004672 GO:0004674 GO:0001102 GO:0003714 GO:0046790 GO:0008344 GO:0007628 GO:0009952 GO:0006978 GO:0048596 GO:0060059 GO:0042771 GO:0061072 GO:0060235 GO:0030514 GO:0043524 GO:0000122 GO:0030182 GO:0018105 GO:0018107 GO:0045766 GO:0008284 GO:0043388 GO:0046330 GO:0032092 GO:0001934 GO:0051091 GO:0045944 GO:0030511 GO:0006468 GO:0010842 GO:0060395 GO:0007224 GO:0006351 GO:0007179 GO:0050882
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008283	cell proliferation	PMID:20307497^[1]	ECO:0000315			P		figure 4C	complete
	GO:0010629	negative regulation of gene expression	PMID:20307497^[1]	ECO:0000315			P		figure 4D	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:16407227^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060235	lens induction in camera-type eye	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010842	retina layer formation	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20579985^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:16407227^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16407227^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:16407227^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:16407227^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16407227^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16407227^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003713	transcription coactivator activity	PMID:16407227^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:16407227^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63015	F		Seeded From UniProt	complete
enables	GO:0046790	virion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H2X6	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0003677	DNA binding	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9748262^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050882	voluntary musculoskeletal movement	PMID:17159989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487301	P		Seeded From UniProt	complete
enables	GO:0046790	virion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17159989^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051 MGI:MGI:1201674 MGI:MGI:894293 MGI:MGI:98727 MGI:MGI:98727	P	has_regulation_target:(MGI:MGI:3616404)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:17159989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487301	P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:16537918^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872 MGI:MGI:98834	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:16537918^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:17159989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16537918^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:17159989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16537918^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P	occurs_in:(EMAPA:16183) occurs_in:(CL:0000222)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:17159989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11078605^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10919273^[8]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9H422	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:20360400^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98384	P	regulates_o_has_input:(MGI:MGI:103036)	Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
enables	GO:0046790	virion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	F		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	C		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H2X6 ensembl:ENSP00000385571	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:12529400^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kim, EA et al. (2006) Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J. Biol. Chem. 281 7489-97 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Isono, K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol. Cell. Biol. 26 2758-71 PubMed GONUTS page
↑ Wang, W et al. (2000) Identification and cloning of a CD43-associated serine/threonine kinase. Cell. Immunol. 205 34-9 PubMed GONUTS page
↑ Ebling, FJ et al. (2000) Estrogenic induction of spermatogenesis in the hypogonadal mouse. Endocrinology 141 2861-9 PubMed GONUTS page
↑ Tsuruyama, T et al. (2010) Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. J. Leukoc. Biol. 88 107-16 PubMed GONUTS page
↑ Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page

[PMID:20307497-1] 1.0 ^1.1 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page

[PMID:16407227-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kim, EA et al. (2006) Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J. Biol. Chem. 281 7489-97 PubMed GONUTS page

[PMID:20579985-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page

[PMID:9748262-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page

[PMID:17159989-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page

[PMID:16537918-6] 6.0 ^6.1 ^6.2 ^6.3 Isono, K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol. Cell. Biol. 26 2758-71 PubMed GONUTS page

[PMID:11078605-7] Wang, W et al. (2000) Identification and cloning of a CD43-associated serine/threonine kinase. Cell. Immunol. 205 34-9 PubMed GONUTS page

[PMID:10919273-8] Ebling, FJ et al. (2000) Estrogenic induction of spermatogenesis in the hypogonadal mouse. Endocrinology 141 2861-9 PubMed GONUTS page

[PMID:20360400-9] Tsuruyama, T et al. (2010) Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. J. Leukoc. Biol. 88 107-16 PubMed GONUTS page

[PMID:12529400-10] Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page

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MOUSE:HIPK2

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