MOUSE:BMP6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bmp6 (synonyms: Bmp-6, Vgr1)
Protein Name(s)	Bone morphogenetic protein 6 BMP-6 VG-1-related protein VGR-1
External Links
UniProt	P20722
EMBL	X80992 U73520 U73515 U73516 U73517 U73518 U73519 BC138593 BC138595 J04566
CCDS	CCDS26462.1
PIR	A54798
RefSeq	NP_031582.1
UniGene	Mm.385759
ProteinModelPortal	P20722
SMR	P20722
BioGrid	198366
PRIDE	P20722
Ensembl	ENSMUST00000171970
GeneID	12161
KEGG	mmu:12161
UCSC	uc007qdp.1
CTD	654
MGI	MGI:88182
eggNOG	NOG272883
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249476
HOVERGEN	HBG004860
InParanoid	P20722
KO	K16620
OMA	WWGLLCS
OrthoDB	EOG7J9VPQ
PhylomeDB	P20722
TreeFam	TF316134
NextBio	280511
PRO	PR:P20722
Proteomes	UP000000589
Bgee	P20722
CleanEx	MM_BMP6
ExpressionAtlas	P20722
Genevestigator	P20722
GO	GO:0005737 GO:0005615 GO:0031988 GO:0070700 GO:0046982 GO:0030509 GO:0051216 GO:0030154 GO:0006879 GO:0071260 GO:0001958 GO:0001654 GO:0040007 GO:0006955 GO:0006954 GO:0001822 GO:0030539 GO:0001649 GO:0032349 GO:2000860 GO:0030501 GO:0032332 GO:0045603 GO:0001938 GO:0045666 GO:0045669 GO:0010862 GO:0014823 GO:0051384 GO:0010039 GO:0032026 GO:0032526 GO:0060395 GO:0003323
Gene3D	2.10.90.10
InterPro	IPR029034 IPR002405 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PRINTS	PR00669
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005615	extracellular space	PMID:24006456^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P70340)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P97454)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q9JIW5)	Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P70340) part_of:(GO:0030509)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P97454) part_of:(GO:0030509)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q9JIW5) part_of:(GO:0030509)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) part_of:(GO:0030509)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:Q9EQ21)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P20067)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:O35253)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q99NA2)	Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002114) has_regulation_target:(UniProtKB:Q925G2)\|occurs_in(UBERON:0002114) has_regulation_target:(UniProtKB:P49282)\|occurs_in(UBERON:0002114) has_regulation_target:(UniProtKB:Q9JHI9)	Seeded From UniProt	complete
involved_in	GO:0071281	cellular response to iron ion	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000182)\|occurs_in:(CL:0002064)\|occurs_in:(UBERON:0000948)\|occurs_in:(UBERON:0006534)	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:19252488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000182)\|occurs_in:(CL:0002064)\|occurs_in:(UBERON:0000948)\|occurs_in:(UBERON:0006534)	Seeded From UniProt	complete
involved_in	GO:0045603	positive regulation of endothelial cell differentiation	PMID:20406889^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20406889^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12151307^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:16154126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:16154126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000932177 UniProtKB:P22003 UniProtKB:P22004	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:88182 PANTHER:PTN000932177 UniProtKB:P18075 UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000860	positive regulation of aldosterone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:7811286^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7811286^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:9786991^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032349	positive regulation of aldosterone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030539	male genitalia development	PMID:9664685^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88181	P	results_in_development_of:(EMAPA:29769)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19852960^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:14623234^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:14623245^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2159013	P	results_in_acquisition_of_features_of:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	PMID:21703414^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136985	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003323	type B pancreatic cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:9664685^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136985	P	occurs_in:(EMAPA:18344)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:16109715^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88177	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2214	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0032349	positive regulation of aldosterone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:0003323	type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22004 ensembl:ENSP00000283147	P		Seeded From UniProt	complete
involved_in	GO:2000860	positive regulation of aldosterone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0032026	response to magnesium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	C		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	C		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04906 ensembl:ENSRNOP00000018359	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	PMID:25860887^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(CHEBI:18248)	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page
↑ ^3.0 ^3.1 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page
↑ Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Oxburgh, L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev. Biol. 286 637-46 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
↑ Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Solloway, MJ et al. (1998) Mice lacking Bmp6 function. Dev. Genet. 22 321-39 PubMed GONUTS page
↑ Miwa, H et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett. 583 3643-8 PubMed GONUTS page
↑ Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page
↑ Yang, Z et al. (2003) Math5 determines the competence state of retinal ganglion cell progenitors. Dev. Biol. 264 240-54 PubMed GONUTS page
↑ Hadziahmetovic, M et al. (2011) Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am. J. Pathol. 179 335-48 PubMed GONUTS page
↑ Kugimiya, F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J. Biol. Chem. 280 35704-12 PubMed GONUTS page
↑ Rausa, M et al. (2015) Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload? PLoS ONE 10 e0122696 PubMed GONUTS page

[PMID:24006456-1] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:19252488-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page

[PMID:20406889-3] 3.0 ^3.1 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

[PMID:12151307-4] Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page

[PMID:16154126-5] 5.0 ^5.1 Oxburgh, L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev. Biol. 286 637-46 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7811286-7] 7.0 ^7.1 Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

[PMID:9786991-8] Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page

[PMID:9664685-9] 9.0 ^9.1 Solloway, MJ et al. (1998) Mice lacking Bmp6 function. Dev. Genet. 22 321-39 PubMed GONUTS page

[PMID:19852960-10] Miwa, H et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett. 583 3643-8 PubMed GONUTS page

[PMID:14623234-11] Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page

[PMID:14623245-12] Yang, Z et al. (2003) Math5 determines the competence state of retinal ganglion cell progenitors. Dev. Biol. 264 240-54 PubMed GONUTS page

[PMID:21703414-13] Hadziahmetovic, M et al. (2011) Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am. J. Pathol. 179 335-48 PubMed GONUTS page

[PMID:16109715-14] Kugimiya, F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J. Biol. Chem. 280 35704-12 PubMed GONUTS page

[PMID:25860887-15] Rausa, M et al. (2015) Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload? PLoS ONE 10 e0122696 PubMed GONUTS page

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MOUSE:BMP6

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