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MOUSE:BMP4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Bmp4 (synonyms: Bmp-4, Dvr-4)
Protein Name(s) Bone morphogenetic protein 4

BMP-4 Bone morphogenetic protein 2B BMP-2B

External Links
UniProt P21275
EMBL X56848
D14814
S65032
L47480
BC013459
BC034053
BC052846
CCDS CCDS36897.1
PIR I49541
JH0801
RefSeq NP_031580.2
XP_006518530.1
XP_006518531.1
UniGene Mm.6813
ProteinModelPortal P21275
SMR P21275
BioGrid 198364
STRING 10090.ENSMUSP00000098242
BindingDB P21275
ChEMBL CHEMBL2384894
PhosphoSite P21275
MaxQB P21275
PRIDE P21275
Ensembl ENSMUST00000074077
ENSMUST00000100676
GeneID 12159
KEGG mmu:12159
UCSC uc007thd.2
CTD 652
MGI MGI:88180
eggNOG NOG243555
HOGENOM HOG000249478
HOVERGEN HBG004860
InParanoid P21275
KO K04662
OMA ATLLHMF
OrthoDB EOG7WHH9D
PhylomeDB P21275
TreeFam TF351789
Reactome REACT_198998
NextBio 280503
PRO PR:P21275
Proteomes UP000000589
Bgee P21275
CleanEx MM_BMP4
ExpressionAtlas P21275
Genevestigator P21275
GO GO:0005576
GO:0005615
GO:0005578
GO:0070700
GO:0042056
GO:0008201
GO:0000186
GO:0048646
GO:0001525
GO:0009948
GO:0001568
GO:0002043
GO:0030509
GO:0003130
GO:0071893
GO:0061151
GO:0061149
GO:0060348
GO:0060442
GO:0001658
GO:0048754
GO:0060433
GO:0060503
GO:0060449
GO:0043010
GO:0048593
GO:0055007
GO:0045165
GO:0071363
GO:0002062
GO:0060197
GO:0007182
GO:0060363
GO:0035993
GO:0021904
GO:0048701
GO:0042733
GO:0035116
GO:0030326
GO:0048598
GO:0060272
GO:0048706
GO:0048704
GO:0001958
GO:0060502
GO:0060441
GO:0060684
GO:0060429
GO:0030218
GO:0030900
GO:0007281
GO:0072104
GO:0072015
GO:0007507
GO:0002244
GO:0060113
GO:0048392
GO:0001822
GO:0060235
GO:0048286
GO:0030324
GO:0060425
GO:0002320
GO:0030225
GO:0060592
GO:0072161
GO:2001012
GO:0072198
GO:0072138
GO:0003337
GO:0001707
GO:0048333
GO:0007500
GO:0001823
GO:0072205
GO:0001656
GO:0030224
GO:0043066
GO:0072097
GO:0090191
GO:0045786
GO:0060548
GO:0008285
GO:2000137
GO:0032331
GO:0050680
GO:0010629
GO:0072125
GO:0090194
GO:0033088
GO:0043407
GO:0072200
GO:2000007
GO:2000005
GO:0045839
GO:0045662
GO:0042326
GO:0060686
GO:0045843
GO:0070244
GO:0000122
GO:0045892
GO:0001843
GO:0048663
GO:0042476
GO:0042475
GO:0001759
GO:0001649
GO:0021983
GO:0050918
GO:0043065
GO:0030513
GO:0030501
GO:0061047
GO:0055020
GO:0061036
GO:0010942
GO:0045597
GO:0008284
GO:0032967
GO:2000105
GO:0045603
GO:0010595
GO:0001938
GO:0045606
GO:0050679
GO:0070374
GO:0010628
GO:0090184
GO:0045666
GO:0045778
GO:0045669
GO:0010862
GO:0032092
GO:0001934
GO:0060391
GO:0048661
GO:0045944
GO:0045893
GO:0030949
GO:0009791
GO:0060512
GO:0034504
GO:0061155
GO:0060687
GO:0061035
GO:0045595
GO:0010453
GO:0001936
GO:0010468
GO:0060688
GO:0042487
GO:0060393
GO:0042306
GO:0051150
GO:0048660
GO:0072001
GO:0003014
GO:0003139
GO:0001501
GO:0060395
GO:0051145
GO:0048745
GO:0007224
GO:0010159
GO:0072101
GO:0043401
GO:0021537
GO:0021978
GO:0035990
GO:0009888
GO:0060438
GO:0060440
GO:0003323
GO:0072192
GO:0072193
GO:0001657
GO:0001944
Gene3D 2.10.90.10
InterPro IPR029034
IPR001839
IPR001111
IPR015615
IPR017948
PANTHER PTHR11848
Pfam PF00019
PF00688
SMART SM00204
SUPFAM SSF57501
PROSITE PS00250
PS51362

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1905312

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

PMID:23863481[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P23359

P

Seeded From UniProt

complete

involved_in

GO:0061312

BMP signaling pathway involved in heart development

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

PMID:21145505[3]

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS00002075FA_10090,RNAcentral:URS0000574A2C_10090

P

occurs_in:(UBERON:0000922)

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

PMID:21145505[3]

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS000075EEC2_10090

P

occurs_in:(UBERON:0000922)

Seeded From UniProt

complete

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

PMID:23863481[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P23359

P

occurs_in:(UBERON:0004145)

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P23359)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P97474)|has_regulation_target:(UniProtKB:Q62181)|has_regulation_target:(UniProtKB:Q61039)|has_regulation_target:(UniProtKB:Q64279)

Seeded From UniProt

complete

involved_in

GO:0060976

coronary vasculature development

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001135)

Seeded From UniProt

complete

involved_in

GO:1901964

positive regulation of cell proliferation involved in outflow tract morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004145)

Seeded From UniProt

complete

involved_in

GO:0003149

membranous septum morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003184

pulmonary valve morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003148

outflow tract septum morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061626

pharyngeal arch artery morphogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003277

apoptotic process involved in endocardial cushion morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003197

endocardial cushion development

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004699)

Seeded From UniProt

complete

NOT|involved_in

GO:0003198

epithelial to mesenchymal transition involved in endocardial cushion formation

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:1905072

cardiac jelly development

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003184

pulmonary valve morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003150

muscular septum morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003215

cardiac right ventricle morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003148

outflow tract septum morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003149

membranous septum morphogenesis

PMID:18924235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055007

cardiac muscle cell differentiation

PMID:21145505[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P21274

P

occurs_in:(UBERON:0004145)

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

PMID:21145505[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P21274

P

  • has_regulation_target:(RNAcentral:URS000075EEC2_10090)
  • has_regulation_target:(RNAcentral:URS00002075FA_10090)
  • has_regulation_target:(RNAcentral:URS0000574A2C_10090)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:19001364[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:24603907[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045606

positive regulation of epidermal cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0010453

regulation of cell fate commitment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045603

positive regulation of endothelial cell differentiation

PMID:20406889[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:20406889[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001012

mesenchymal cell differentiation involved in renal system development

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000137

negative regulation of cell proliferation involved in heart morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:2000007

negative regulation of metanephric comma-shaped body morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:2000005

negative regulation of metanephric S-shaped body morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0090194

negative regulation of glomerulus development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

PMID:15634693[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0090184

positive regulation of kidney development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0072205

metanephric collecting duct development

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072200

negative regulation of mesenchymal cell proliferation involved in ureter development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0072198

mesenchymal cell proliferation involved in ureter development

PMID:17442697[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072193

ureter smooth muscle cell differentiation

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072192

ureter epithelial cell differentiation

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072161

mesenchymal cell differentiation involved in kidney development

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072138

mesenchymal cell proliferation involved in ureteric bud development

PMID:17442697[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072125

negative regulation of glomerular mesangial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0072104

glomerular capillary formation

PMID:18272846[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0072015

glomerular visceral epithelial cell development

PMID:17442697[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071893

BMP signaling pathway involved in nephric duct formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

enables

GO:0070700

BMP receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0070244

negative regulation of thymocyte apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0061155

pulmonary artery endothelial tube morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0061151

BMP signaling pathway involved in renal system segmentation

PMID:17442697[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061149

BMP signaling pathway involved in ureter morphogenesis

PMID:17442697[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061047

positive regulation of branching involved in lung morphogenesis

PMID:17350185[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0060197

cloacal septation

PMID:17442697[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055020

positive regulation of cardiac muscle fiber development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0055007

cardiac muscle cell differentiation

PMID:9857019[12]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0048754

branching morphogenesis of an epithelial tube

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0048745

smooth muscle tissue development

PMID:12631064[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0048392

intermediate mesodermal cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045839

negative regulation of mitotic nuclear division

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:12631064[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0042326

negative regulation of phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0035993

deltoid tuberosity development

PMID:20059955[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035990

tendon cell differentiation

PMID:20059955[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034504

protein localization to nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0033088

negative regulation of immature T cell proliferation in thymus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

PMID:20059955[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0003323

type B pancreatic cell development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0003139

secondary heart field specification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0003130

BMP signaling pathway involved in heart induction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0002320

lymphoid progenitor cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

PMID:20059955[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0001958

endochondral ossification

PMID:20059955[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0001823

mesonephros development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:16154126[15]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P23359

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0001658

branching involved in ureteric bud morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

NOT|involved_in

GO:0001654

eye development

PMID:16154126[15]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P23359

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

enables

GO:0070700

BMP receptor binding

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218890
UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338027
MGI:MGI:88180
MGI:MGI:88182
MGI:MGI:95689
MGI:MGI:97359
PANTHER:PTN000218063
UniProtKB:O95390
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22004
UniProtKB:P43026
UniProtKB:P61812
UniProtKB:Q6KF10
UniProtKB:Q99988

P

Seeded From UniProt

complete

involved_in

GO:0048468

cell development

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103302
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88180
PANTHER:PTN000218890
UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98726
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95689
MGI:MGI:95690
PANTHER:PTN000218210
RGD:2211
UniProtKB:O95393
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
MGI:MGI:1338820
MGI:MGI:88182
MGI:MGI:95684
MGI:MGI:98727
PANTHER:PTN000218063
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P08476
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22003
UniProtKB:P22004
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q96S42
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000490
MGI:MGI:103302
MGI:MGI:1338027
MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95691
MGI:MGI:98725
MGI:MGI:98726
PANTHER:PTN000218063
RGD:1305979
RGD:2211
RGD:2212
RGD:2213
RGD:2214
RGD:2912
RGD:2913
RGD:3115
RGD:3851
RGD:62074
RGD:620743
RGD:621512
RGD:69051
RGD:70491
UniProtKB:O14793
UniProtKB:O42220
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P30371
UniProtKB:P61812
UniProtKB:Q96S42
UniProtKB:Q99988
WB:WBGene00000903

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218063
UniProtKB:P61812

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218063
UniProtKB:P08476
UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[16]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88180
PANTHER:PTN000218890
UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000353

positive regulation of endothelial cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000137

negative regulation of cell proliferation involved in heart morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000007

negative regulation of metanephric comma-shaped body morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000005

negative regulation of metanephric S-shaped body morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902462

positive regulation of mesenchymal stem cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901341

positive regulation of store-operated calcium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090194

negative regulation of glomerulus development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

PMID:21281623[17]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102780

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090184

positive regulation of kidney development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072200

negative regulation of mesenchymal cell proliferation involved in ureter development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

PMID:24603907[6]

ECO:0000315

P

Figure 2 Demonstrates BMP compared to its inhibitor, DMH1. The data shows that BMP has a greater affected on the wound.

complete
CACAO 9854

acts_upstream_of_or_within

GO:0072125

negative regulation of glomerular mesangial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071893

BMP signaling pathway involved in nephric duct formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071773

cellular response to BMP stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071549

cellular response to dexamethasone stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071363

cellular response to growth factor stimulus

PMID:7848824[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:19001364[5]

ECO:0000314

P

Figure 1. Levels of mRNA expression relative to control mRNA (HPRT) of six putative target genes (Gas1, Olig1, Id2, Idb4, CXXC5, Hey1) in NSCs after BMP4 treatment.

complete
CACAO 7533

enables

GO:0070700

BMP receptor binding

PMID:7811286[19]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:18692041[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070372

regulation of ERK1 and ERK2 cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070368

positive regulation of hepatocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070244

negative regulation of thymocyte apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061155

pulmonary artery endothelial tube morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061036

positive regulation of cartilage development

PMID:3201241[21]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061035

regulation of cartilage development

PMID:20501701[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060688

regulation of morphogenesis of a branching structure

PMID:11401393[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

regulates_o_results_in_morphogenesis_of:(EMAPA:19287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060687

regulation of branching involved in prostate gland morphogenesis

PMID:15772937[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

regulates_o_occurs_in:(EMAPA:19287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060686

negative regulation of prostatic bud formation

PMID:11401393[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

regulates_o_results_in_formation_of:(EMAPA:19287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060686

negative regulation of prostatic bud formation

PMID:18393306[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060684

epithelial-mesenchymal cell signaling

PMID:8104708[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060592

mammary gland formation

PMID:17071745[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_formation_of:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060512

prostate gland morphogenesis

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060512

prostate gland morphogenesis

PMID:11401393[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060503

bud dilation involved in lung branching

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060502

epithelial cell proliferation involved in lung morphogenesis

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060449

bud elongation involved in lung branching

PMID:18367557[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060442

branching involved in prostate gland morphogenesis

PMID:11401393[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060440

trachea formation

PMID:18692041[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3797048

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060438

trachea development

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060433

bronchus development

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060429

epithelium development

PMID:8898217[31]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:32906)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060425

lung morphogenesis

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060395

SMAD protein signal transduction

PMID:9420335[32]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060395

SMAD protein signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060363

cranial suture morphogenesis

PMID:9477322[33]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060348

bone development

PMID:8358941[34]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060272

embryonic skeletal joint morphogenesis

PMID:9664686[35]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:103302

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060272

embryonic skeletal joint morphogenesis

PMID:9664686[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060235

lens induction in camera-type eye

PMID:9851982[36]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

has_participant:(EMAPA:16540)|has_participant:(EMAPA:16672)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060113

inner ear receptor cell differentiation

PMID:17555714[37]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95524

P

  • occurs_in:(EMAPA:17597)
  • results_in_acquisition_of_features_of:(CL:0000601)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055020

positive regulation of cardiac muscle fiber development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051150

regulation of smooth muscle cell differentiation

PMID:17881493[38]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1347470

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000222)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051150

regulation of smooth muscle cell differentiation

PMID:17881493[38]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000222)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051145

smooth muscle cell differentiation

PMID:16546160[39]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17373)
  • results_in_acquisition_of_features_of:(CL:0000192)|occurs_in(EMAPA:17373)
  • results_in_acquisition_of_features_of:(CL:0000669)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050680

negative regulation of epithelial cell proliferation

PMID:11401393[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048754

branching morphogenesis of an epithelial tube

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048715

negative regulation of oligodendrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048706

embryonic skeletal system development

PMID:16712836[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

results_in_development_of:(EMAPA:17674)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048704

embryonic skeletal system morphogenesis

PMID:16712836[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

has_participant:(EMAPA:17674)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048701

embryonic cranial skeleton morphogenesis

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048663

neuron fate commitment

PMID:17698011[41]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

  • has_participant:(EMAPA:16797)
  • results_in_commitment_to:(CL:0000111)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048663

neuron fate commitment

PMID:17698011[41]

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_participant:(EMAPA:16797)
  • results_in_commitment_to:(CL:0000111)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048660

regulation of smooth muscle cell proliferation

PMID:15800000[42]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048646

anatomical structure formation involved in morphogenesis

PMID:16916379[43]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104327

P

results_in_formation_of:(EMAPA:16833)|results_in_formation_of:(EMAPA:16853)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048598

embryonic morphogenesis

PMID:15716346[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176835,MGI:MGI:3041440

P

has_participant:(EMAPA:16808)|has_participant:(EMAPA:17359)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048593

camera-type eye morphogenesis

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:88180

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048392

intermediate mesodermal cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048333

mesodermal cell differentiation

PMID:7799920[45]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048286

lung alveolus development

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8898217[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97168

P

has_regulation_target:(MGI:MGI:88180)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10340755[46]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97168

P

has_regulation_target:(MGI:MGI:105373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18692041[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9501024[47]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9477322[33]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97168)|has_regulation_target:(MGI:MGI:97169)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8898217[31]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:32906)
  • regulates_o_occurs_in:(CL:0000134)
  • has_regulation_target:(MGI:MGI:88180)|regulates_o_occurs_in(EMAPA:32906)
  • regulates_o_occurs_in:(CL:0000134)
  • has_regulation_target:(MGI:MGI:96770)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8769660[48]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97168)|has_regulation_target:(MGI:MGI:97169)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8104708[26]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97168)|has_regulation_target:(MGI:MGI:97169)|has_regulation_target:(MGI:MGI:95295)|has_regulation_target:(MGI:MGI:88180)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18997172[49]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1933533)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18776146[50]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:2442819)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18692041[20]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:88313)|has_regulation_target:(MGI:MGI:96396)|has_regulation_target:(MGI:MGI:96397)|has_regulation_target:(MGI:MGI:96398)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10391928[51]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000034)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9187146[52]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:7911662[53]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06826

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045843

negative regulation of striated muscle tissue development

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045839

negative regulation of mitotic nuclear division

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045786

negative regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045778

positive regulation of ossification

PMID:8358941[34]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045778

positive regulation of ossification

PMID:7911662[53]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06826

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045778

positive regulation of ossification

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045778

positive regulation of ossification

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045666

positive regulation of neuron differentiation

PMID:9786991[54]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045606

positive regulation of epidermal cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045597

positive regulation of cell differentiation

PMID:15525533[55]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17919)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000059)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045595

regulation of cell differentiation

PMID:15525533[55]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95586

P

  • regulates_o_occurs_in:(EMAPA:17919)
  • regulates_o_occurs_in:(CL:0000059)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045595

regulation of cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045165

cell fate commitment

PMID:12421925[56]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043407

negative regulation of MAP kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:9187146[52]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:14681194[57]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2137520

P

results_in_development_of:(EMAPA:17168)|results_in_development_of:(EMAPA:17838)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:9268572[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108359
MGI:MGI:95729

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042487

regulation of odontogenesis of dentin-containing tooth

PMID:9244299[58]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88177
MGI:MGI:99604

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042476

odontogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:16179481[59]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1913292

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:16179481[59]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:15525533[55]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(EMAPA:17919)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042326

negative regulation of phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042306

regulation of protein import into nucleus

PMID:22529382[60]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

enables

GO:0039706

co-receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035116

embryonic hindlimb morphogenesis

PMID:10964473[61]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104903

P

results_in_development_of:(EMAPA:17458)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034599

cellular response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034504

protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033088

negative regulation of immature T cell proliferation in thymus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032331

negative regulation of chondrocyte differentiation

PMID:17481601[62]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17244)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000138)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032092

positive regulation of protein binding

PMID:23610558[63]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:14681194[57]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2137520

P

results_in_development_of:(EMAPA:16656)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030509

BMP signaling pathway

PMID:15975920[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2679262

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030509

BMP signaling pathway

PMID:17472960[65]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000192)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030509

BMP signaling pathway

PMID:14623234[66]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030509

BMP signaling pathway

PMID:17472960[65]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030509

BMP signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030501

positive regulation of bone mineralization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030501

positive regulation of bone mineralization

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030326

embryonic limb morphogenesis

PMID:9664686[35]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:103302

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030326

embryonic limb morphogenesis

PMID:9664686[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:16414041[67]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2181190,MGI:MGI:3574949

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030225

macrophage differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030224

monocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030218

erythrocyte differentiation

PMID:15591122[68]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021983

pituitary gland development

PMID:9806931[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

results_in_development_of:(EMAPA:16574)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021978

telencephalon regionalization

PMID:11719201[70]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96785

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021978

telencephalon regionalization

PMID:16855091[71]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(EMAPA:16910)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021904

dorsal/ventral neural tube patterning

PMID:15218525[72]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021537

telencephalon development

PMID:9187146[52]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010976

positive regulation of neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010942

positive regulation of cell death

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

PMID:11493558[73]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:18622394[74]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010524

positive regulation of calcium ion transport into cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:11436557[75]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:98297)|has_regulation_target:(MGI:MGI:88177)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:10704389[76]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:98297)|has_regulation_target:(MGI:MGI:88177)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010453

regulation of cell fate commitment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010159

specification of animal organ position

PMID:17071745[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_participant:(EMAPA:16039)|has_participant:(EMAPA:17759)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009948

anterior/posterior axis specification

PMID:10964473[61]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104903

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009888

tissue development

PMID:14681194[57]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2137520

P

results_in_development_of:(EMAPA:16382)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:8674409[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:18028901[77]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104327

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9187146[52]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:18692041[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:15381701[78]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3042751

P

results_in_development_of:(EMAPA:16346)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:12975322[79]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2181190

P

results_in_development_of:(EMAPA:17618)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007500

mesodermal cell fate determination

PMID:7657163[80]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007492

endoderm development

PMID:24835669[81]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:16052)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:15289457[82]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

  • occurs_in:(EMAPA:16039)
  • results_in_development_of:(CL:0000586)|occurs_in(EMAPA:16039)
  • results_in_development_of:(CL:0000586)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:17481601[62]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:8358941[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003323

type B pancreatic cell development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003139

secondary heart field specification

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003130

BMP signaling pathway involved in heart induction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003014

renal system process

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002320

lymphoid progenitor cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002244

hematopoietic progenitor cell differentiation

PMID:7799920[45]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001944

vasculature development

PMID:17881493[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

PMID:18692041[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001843

neural tube closure

PMID:19850029[83]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:9268572[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001759

organ induction

PMID:9806931[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857137

P

regulates_o_results_in_development_of:(EMAPA:16512)|regulates_o_results_in_development_of:(EMAPA:16574)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001707

mesoderm formation

PMID:7799920[45]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001707

mesoderm formation

PMID:18462699[84]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:17522159[85]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1344337

P

has_participant:(EMAPA:17376)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001657

ureteric bud development

PMID:12631064[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

results_in_development_of:(EMAPA:17950)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001657

ureteric bud development

PMID:12631064[13]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:17376)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001657

ureteric bud development

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001656

metanephros development

PMID:12631064[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158495

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001656

metanephros development

PMID:12631064[13]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001649

osteoblast differentiation

PMID:15381701[78]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001649

osteoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001568

blood vessel development

PMID:1521591[86]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2213

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001525

angiogenesis

PMID:15070745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3042751

P

has_participant:(EMAPA:16684)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:15936012[87]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2654594,MGI:MGI:3041440

P

results_in_development_of:(EMAPA:16383)|results_in_development_of:(EMAPA:16384)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:14654219[88]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:17937)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000186

activation of MAPKK activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9585504[89]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97485)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9187146[52]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:2000137

negative regulation of cell proliferation involved in heart morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:2000007

negative regulation of metanephric comma-shaped body morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:2000005

negative regulation of metanephric S-shaped body morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0090194

negative regulation of glomerulus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0090184

positive regulation of kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0072200

negative regulation of mesenchymal cell proliferation involved in ureter development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0072125

negative regulation of glomerular mesangial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0072001

renal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0071893

BMP signaling pathway involved in nephric duct formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0071773

cellular response to BMP stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

enables

GO:0070700

BMP receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

F

Seeded From UniProt

complete

involved_in

GO:0070244

negative regulation of thymocyte apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0061155

pulmonary artery endothelial tube morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0061036

positive regulation of cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060503

bud dilation involved in lung branching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060502

epithelial cell proliferation involved in lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060441

epithelial tube branching involved in lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060438

trachea development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060433

bronchus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060425

lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0055020

positive regulation of cardiac muscle fiber development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0048754

branching morphogenesis of an epithelial tube

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0048392

intermediate mesodermal cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0048286

lung alveolus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045843

negative regulation of striated muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045839

negative regulation of mitotic nuclear division

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045778

positive regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0045606

positive regulation of epidermal cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0042326

negative regulation of phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0042306

regulation of protein import into nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

F

Seeded From UniProt

complete

enables

GO:0039706

co-receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

F

Seeded From UniProt

complete

involved_in

GO:0034504

protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0033088

negative regulation of immature T cell proliferation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0030225

macrophage differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0030224

monocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0021537

telencephalon development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0010453

regulation of cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0009791

post-embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

F

Seeded From UniProt

complete

involved_in

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0003323

type B pancreatic cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0003139

secondary heart field specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0003130

BMP signaling pathway involved in heart induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0002320

lymphoid progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001823

mesonephros development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001658

branching involved in ureteric bud morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12644
ensembl:ENSP00000245451

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001839
InterPro:IPR017948

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20406889[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

PMID:20406889[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

PMID:20406889[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001936

regulation of endothelial cell proliferation

PMID:20406889[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0891

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Bai, Y et al. (2013) Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140 3395-402 PubMed GONUTS page
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Liu, W et al. (2004) Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc. Natl. Acad. Sci. U.S.A. 101 4489-94 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Wang, J et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev. Cell 19 903-12 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 McCulley, DJ et al. (2008) BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev. Dyn. 237 3200-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 Andersson, T et al. (2009) CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J. Biol. Chem. 284 3672-81 PubMed GONUTS page
  6. ↑ 6.0 6.1 Hao, J et al. (2014) DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. PLoS ONE 9 e90748 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 Brenner-Anantharam, A et al. (2007) Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134 1967-75 PubMed GONUTS page
  9. ↑ Levinson, RS et al. (2005) Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 132 529-39 PubMed GONUTS page
  10. ↑ Ueda, H et al. (2008) Bmp in podocytes is essential for normal glomerular capillary formation. J. Am. Soc. Nephrol. 19 685-94 PubMed GONUTS page
  11. ↑ Zhu, NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393 70-80 PubMed GONUTS page
  12. ↑ Skerjanc, IS et al. (1998) Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells. J. Biol. Chem. 273 34904-10 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 13.4 13.5 Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 Blitz, E et al. (2009) Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev. Cell 17 861-73 PubMed GONUTS page
  15. ↑ 15.0 15.1 Oxburgh, L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev. Biol. 286 637-46 PubMed GONUTS page
  16. ↑ 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  17. ↑ Nie, X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 352 141-51 PubMed GONUTS page
  18. ↑ Bègue-Kirn, C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int. J. Dev. Biol. 38 405-20 PubMed GONUTS page
  19. ↑ Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 20.3 20.4 20.5 Li, Y et al. (2008) Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev. Biol. 322 145-55 PubMed GONUTS page
  21. ↑ Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page
  22. ↑ Karamboulas, K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J. Cell. Sci. 123 2068-76 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 23.4 Lamm, ML et al. (2001) Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev. Biol. 232 301-14 PubMed GONUTS page
  24. ↑ Almahbobi, G et al. (2005) Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4. J. Pathol. 206 52-61 PubMed GONUTS page
  25. ↑ Vezina, CM et al. (2008) Retinoic acid induces prostatic bud formation. Dev. Dyn. 237 1321-33 PubMed GONUTS page
  26. ↑ 26.0 26.1 Vainio, S et al. (1993) Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75 45-58 PubMed GONUTS page
  27. ↑ 27.0 27.1 Cho, KW et al. (2006) Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc. Natl. Acad. Sci. U.S.A. 103 16788-93 PubMed GONUTS page
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  32. ↑ Sirard, C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12 107-19 PubMed GONUTS page
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  42. ↑ Mailleux, AA et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132 2157-66 PubMed GONUTS page
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  47. ↑ Biben, C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol. 194 135-51 PubMed GONUTS page
  48. ↑ Thesleff, I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245 151-61 PubMed GONUTS page
  49. ↑ Truksa, J et al. (2009) Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 113 688-95 PubMed GONUTS page
  50. ↑ Caubit, X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135 3301-10 PubMed GONUTS page
  51. ↑ Hollnagel, A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274 19838-45 PubMed GONUTS page
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  54. ↑ Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page
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  56. ↑ Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page
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  58. ↑ Neubüser, A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90 247-55 PubMed GONUTS page
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  60. ↑ Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page
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  62. ↑ 62.0 62.1 Yu, L et al. (2007) Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev. Biol. 306 549-59 PubMed GONUTS page
  63. ↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
  64. ↑ Babitt, JL et al. (2005) Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J. Biol. Chem. 280 29820-7 PubMed GONUTS page
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  66. ↑ Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page
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  68. ↑ Lenox, LE et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105 2741-8 PubMed GONUTS page
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