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PMID:19850029

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Citation

Misra, K and Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337:74-83

Abstract

Both the BMP and Wnt pathways have been implicated in directing aspects of dorsal neural tube closure and cell fate specification. However, the mechanisms that control the diverse responses to these signals are poorly understood. In this study, we provide genetic and functional evidence that the secreted sFRP1 and sFRP2 proteins, which have been primarily implicated as negative regulators of Wnt signaling, can also antagonize BMP signaling in the caudal neural tube and that this function is critical to maintain proper neural tube closure and dorsal cell fate segregation. Our studies thus reveal a novel role for specific sFRP proteins in balancing the response of cells to two critical extracellular signaling pathways.

Links

PubMed Online version:10.1016/j.ydbio.2009.10.015

Keywords

Animals; Bone Morphogenetic Proteins/antagonists & inhibitors; Female; Intercellular Signaling Peptides and Proteins/physiology; Membrane Proteins/physiology; Mice; Neural Crest/embryology; Neural Tube/embryology; Neural Tube Defects/embryology; Pregnancy; Signal Transduction; Spinal Cord/embryology; Wnt Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DKK1

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DKK1

acts_upstream_of_or_within

GO:0030178: negative regulation of Wnt signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MSX1

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P28361

P

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

  • regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

  • regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:NOGG

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CTNB1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:SFRP1

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108078

P

  • regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:SFRP1

acts_upstream_of_or_within

GO:0021915: neural tube development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108078

P

Seeded From UniProt

complete

MOUSE:SFRP1

acts_upstream_of_or_within

GO:0001843: neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108078

P

Seeded From UniProt

complete

MOUSE:SFRP1

acts_upstream_of_or_within

GO:0010629: negative regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3045799

P

Seeded From UniProt

complete

MOUSE:SFRP1

acts_upstream_of_or_within

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108078

P

  • regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:CHRD

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:MSX1

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:WNT1

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:WNT3A

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q3L258

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q5QEB6

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q9PS91

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q9PWH1

involved_in

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0021915: neural tube development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0001843: neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

Seeded From UniProt

complete

MOUSE:SFRP2

acts_upstream_of_or_within

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:892014

P

regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:BMP4

acts_upstream_of_or_within

GO:0001843: neural tube closure

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:WNT1

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:Q91029

P

Seeded From UniProt

complete

MOUSE:CTNB1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:Q2LMP1

P

Seeded From UniProt

complete

MOUSE:SMAD7

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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