PMID:15070745

Citation	Liu, W, Selever, J, Wang, D, Lu, MF, Moses, KA, Schwartz, RJ and Martin, JF (2004) Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc. Natl. Acad. Sci. U.S.A. 101:4489-94
Abstract	The Bmp4 signaling molecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardium, suggesting a role for Bmp4 in OFT development. Inactivation of Bmp4 in the caudal branchial arch and splanchnic mesoderm and OFT myocardium by using a conditional null allele of Bmp4 and the Nkx2.5cre recombinase allele resulted in abnormal morphogenesis of branchial-arch arteries (BAAs) and defective OFT septation. Expression of aortic-sac myocardial markers was reduced and expression of the sm22LacZ transgene, a smooth-muscle marker, was attenuated in BAAs and conotruncus of Nkx2.5cre; Bmp4 conditional mutants. Moreover, we found tissue-specific functions for Bmp4 in the regulation of cellular proliferation and apoptosis. We also demonstrate a strong genetic interaction between Bmp4 and Bmp7 in OFT development. Our findings uncover a previously uncharacterized function for Bmp4 in vascular remodeling of the BAAs, and they show definitively that Bmp4, in cooperation with Bmp7, has a central role in OFT septation.
Links	PubMed PMC384774 Online version:10.1073/pnas.0308466101
Keywords	Animals; Aorta, Thoracic/embryology; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins/deficiency; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/physiology; Branchial Region/blood supply; Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Heart/embryology; Mesoderm/physiology; Mice; Morphogenesis; Signal Transduction; Transforming Growth Factor beta/physiology
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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