HUMAN:GDF8

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MSTN (synonyms: GDF8)
Protein Name(s)	Growth/differentiation factor 8 GDF-8 Myostatin
External Links
UniProt	O14793
EMBL	AF019627 AF104922 DQ927096 DQ927098 DQ927099 BC074757
CCDS	CCDS2303.1
RefSeq	NP_005250.1
UniGene	Hs.41565
ProteinModelPortal	O14793
SMR	O14793
BioGrid	108929
IntAct	O14793
STRING	9606.ENSP00000260950
PhosphoSite	O14793
PaxDb	O14793
PeptideAtlas	O14793
PRIDE	O14793
DNASU	2660
Ensembl	ENST00000260950
GeneID	2660
KEGG	hsa:2660
UCSC	uc002urp.3
CTD	2660
GeneCards	GC02M190920
GeneReviews	MSTN
HGNC	HGNC:4223
HPA	CAB009963
MIM	601788 614160
neXtProt	NX_O14793
Orphanet	275534
PharmGKB	PA162396253
eggNOG	NOG310007
HOGENOM	HOG000006566
HOVERGEN	HBG000217
InParanoid	O14793
KO	K05497
OMA	NPFLEVR
OrthoDB	EOG74R1Q4
PhylomeDB	O14793
TreeFam	TF318514
GeneWiki	Myostatin
GenomeRNAi	2660
NextBio	10500
PRO	PR:O14793
Proteomes	UP000005640
Bgee	O14793
CleanEx	HS_MSTN
ExpressionAtlas	O14793
Genevestigator	O14793
GO	GO:0005737 GO:0005615 GO:0008083 GO:0008201 GO:0042802 GO:0005102 GO:0071549 GO:0007517 GO:0014741 GO:0048632 GO:0022602 GO:0045893 GO:0051602 GO:0043627 GO:0045471 GO:0009629 GO:0009408 GO:0014850 GO:0033574 GO:0014732 GO:0043403 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR015616 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848 PTHR11848:SF13
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:15215484^[1]	ECO:0000315			P	Figure 2; comparison of wild-type versus mutant allele	complete CACAO 2290
	GO:0045662	negative regulation of myoblast differentiation	PMID:19357233^[2]	ECO:0000314			P	Fig. 1 & 4A	complete CACAO 6336
	GO:0046716	muscle cell homeostasis	PMID:19357233^[2]	ECO:0000314			P	Results section/ Myostatin reduces diameters...section/last sentence; Fig. 5c; states myostatin inhibits genes required for muscle maintenance [homeostatsis of muscle] instead of alternative atrophy pathway	complete CACAO 6337
	GO:0051898	negative regulation of protein kinase B signaling cascade	PMID:19357233^[2]	ECO:0000314			P	Fig. 3; Fig 4; demonstrate that mysostatin inhibits the activation of the Akt signaling pathway in differentiating HuSkMC	complete CACAO 6521
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:24451368^[3]	ECO:0000314			P	Results shown in Figure 8 and process is diagrammed in Figure 9.	complete CACAO 9550
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:27625211^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:19357233^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:19357233^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	PMID:19357233^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000818	negative regulation of myoblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902725	negative regulation of satellite cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:15215484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14517293^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:14517293^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36896	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:14517293^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36897	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:14517293^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13705	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12595574^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29330193^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23829672^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0022602	ovulation cycle process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014741	negative regulation of muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015616	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR015616 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:9843994^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	PMID:9843994^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schuelke, M et al. (2004) Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350 2682-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Trendelenburg, AU et al. (2009) Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am. J. Physiol., Cell Physiol. 296 C1258-70 PubMed GONUTS page
↑ Bonala, S et al. (2014) Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. J. Biol. Chem. 289 7654-70 PubMed GONUTS page
↑ Apgar, JR et al. (2016) Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. MAbs 8 1302-1318 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Rebbapragada, A et al. (2003) Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23 7230-42 PubMed GONUTS page
↑ Hill, JJ et al. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol. Endocrinol. 17 1144-54 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cotton, TR et al. (2018) Structure of the human myostatin precursor and determinants of growth factor latency. EMBO J. 37 367-383 PubMed GONUTS page
↑ Szláma, G et al. (2013) Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS J. 280 3822-39 PubMed GONUTS page
↑ ^10.0 ^10.1 Gonzalez-Cadavid, NF et al. (1998) Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc. Natl. Acad. Sci. U.S.A. 95 14938-43 PubMed GONUTS page

[PMID:15215484-1] 1.0 ^1.1 Schuelke, M et al. (2004) Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350 2682-8 PubMed GONUTS page

[PMID:19357233-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Trendelenburg, AU et al. (2009) Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am. J. Physiol., Cell Physiol. 296 C1258-70 PubMed GONUTS page

[PMID:24451368-3] Bonala, S et al. (2014) Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. J. Biol. Chem. 289 7654-70 PubMed GONUTS page

[PMID:27625211-4] Apgar, JR et al. (2016) Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. MAbs 8 1302-1318 PubMed GONUTS page

[PMID:14517293-5] 5.0 ^5.1 ^5.2 ^5.3 Rebbapragada, A et al. (2003) Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23 7230-42 PubMed GONUTS page

[PMID:12595574-6] Hill, JJ et al. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol. Endocrinol. 17 1144-54 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29330193-8] Cotton, TR et al. (2018) Structure of the human myostatin precursor and determinants of growth factor latency. EMBO J. 37 367-383 PubMed GONUTS page

[PMID:23829672-9] Szláma, G et al. (2013) Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS J. 280 3822-39 PubMed GONUTS page

[PMID:9843994-10] 10.0 ^10.1 Gonzalez-Cadavid, NF et al. (1998) Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc. Natl. Acad. Sci. U.S.A. 95 14938-43 PubMed GONUTS page

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HUMAN:GDF8

Contents

Annotations

Notes

References

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