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HUMAN:TCP4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SUB1 (synonyms: PC4, RPO2TC1)
Protein Name(s) Activated RNA polymerase II transcriptional coactivator p15

Positive cofactor 4 PC4 SUB1 homolog p14

External Links
UniProt P53999
EMBL X79805
U12979
BC009610
BC010537
BC018189
BC022339
CCDS CCDS3897.1
PIR A54670
RefSeq NP_006704.3
XP_011512246.1
XP_016864475.1
XP_016864476.1
UniGene Hs.229641
PDB 1PCF
2C62
2PHE
4USG
PDBsum 1PCF
2C62
2PHE
4USG
ProteinModelPortal P53999
SMR P53999
BioGrid 116127
DIP DIP-29044N
IntAct P53999
MINT MINT-138673
STRING 9606.ENSP00000265073
iPTMnet P53999
PhosphoSitePlus P53999
SwissPalm P53999
BioMuta SUB1
DMDM 1709514
EPD P53999
PaxDb P53999
PeptideAtlas P53999
PRIDE P53999
TopDownProteomics P53999
Ensembl ENST00000265073
ENST00000502897
ENST00000506237
ENST00000512913
ENST00000515355
GeneID 10923
KEGG hsa:10923
CTD 10923
DisGeNET 10923
GeneCards SUB1
HGNC HGNC:19985
HPA CAB015351
HPA001311
MIM 600503
neXtProt NX_P53999
OpenTargets ENSG00000113387
PharmGKB PA142670858
eggNOG KOG2712
ENOG410XUB8
GeneTree ENSGT00390000008802
HOVERGEN HBG028243
InParanoid P53999
OMA QWNQLKD
OrthoDB EOG091G14VO
PhylomeDB P53999
TreeFam TF313859
SIGNOR P53999
ChiTaRS SUB1
EvolutionaryTrace P53999
GeneWiki SUB1
GenomeRNAi 10923
PRO PR:P53999
Proteomes UP000005640
Bgee ENSG00000113387
CleanEx HS_SUB1
ExpressionAtlas P53999
Genevisible P53999
GO GO:0070062
GO:0005730
GO:0005634
GO:0005667
GO:0003723
GO:0003697
GO:0003713
GO:0001205
GO:0060261
GO:0006357
GO:0060395
Gene3D 2.30.31.10
InterPro IPR003173
IPR009044
Pfam PF02229
SUPFAM SSF54447

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:20458337[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0051053

negative regulation of DNA metabolic process

PMID:28369605[3]

ECO:0000314

P

Paper’s Protein Name: “Human homolog of Sub1, variously referred to as hSub1, p15 or PC4.” PC4 is primarily used. Uniprot’s Protein Name: Activated RNA polymerase II transcriptional coactivator p15. Organism: Homo sapiens. Notes: Figures 2B-E are all applicable, but I will primarily use 2B. The paper states that “the ectopic expression of Sub1 or PC4 reduced the rate of recombination for the pTET-lys2-GTOP construct by 9.6- and 10.3-fold, respectively, thereby resulting in the rates of recombination that are significantly lower than in top1Δ single deletion strains (Figure 2B).” Thus, PC4 seems to be linked to down-regulation of DNA recombination. The procedures of this experiment involve transforming yeast strains with a “PC4 expression vector,” so the evidence code should be IDA.

complete
CACAO 12427

enables

GO:0003723

RNA binding

PMID:22658674[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:8062391[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:8062391[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:8062391[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:8062391[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000325022
PomBase:SPAC16A10.02

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000325022
UniProtKB:P53999

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015299
PANTHER:PTN000325022
PomBase:SPAC16A10.02
RGD:621582
SGD:S000004642
UniProtKB:P53999

C

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000325022
PomBase:SPAC16A10.02
SGD:S000004642
UniProtKB:P53999

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53999

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16415882[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53999

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11031
ensembl:ENSMUSP00000022816

F

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11031
ensembl:ENSMUSP00000022816

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11031
ensembl:ENSMUSP00000022816

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63396
ensembl:ENSRNOP00000067467

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003173
InterPro:IPR009044

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003173
InterPro:IPR009044

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  2. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  3. ↑ Lopez, CR et al. (2017) Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. PubMed GONUTS page
  4. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Ge, H & Roeder, RG (1994) Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78 513-23 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  8. ↑ Werten, S & Moras, D (2006) A global transcription cofactor bound to juxtaposed strands of unwound DNA. Nat. Struct. Mol. Biol. 13 181-2 PubMed GONUTS page
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