DANRE:Q9PTF9

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	Bone morphogenetic protein 7 (ECO:0000313 with EMBL:AAF17558.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000017352)
External Links
UniProt	Q9PTF9
EMBL	CR925817 CU633826 AF201379
RefSeq	NP_571396.1
UniGene	Dr.77644
SMR	Q9PTF9
Ensembl	ENSDART00000016472
GeneID	30584
KEGG	dre:30584
CTD	30584
ZFIN	ZDB-GENE-000208-25
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249476
HOVERGEN	HBG004860
KO	K16621
OMA	YENETFH
PhylomeDB	Q9PTF9
TreeFam	TF316134
Reactome	REACT_219441
NextBio	20806954
Proteomes	UP000000437
GO	GO:0005576 GO:0046982 GO:0042803 GO:0030509 GO:0003303 GO:0007368 GO:0048264 GO:0009953 GO:0003143 GO:0040007 GO:0001947 GO:0042664 GO:0036342 GO:0006461
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0065003	protein-containing complex assembly	PMID:19377468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-050216-1	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:16527746^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050902-2 ZFIN:ZDB-MRPHLNO-050902-3	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:16527746^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050902-3	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:12601179^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11477698^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050902-3	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:19377468^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O13108	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19377468^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042664	negative regulation of endodermal cell fate specification	PMID:16672336^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-474 ZFIN:ZDB-GENE-980528-2059	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:21610036^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9676195^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19377468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-050216-1	P	Seeded From UniProt	complete
involved_in	GO:0021703	locus ceruleus development	PMID:10595509^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11748837^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-100422-2	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11969259^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11748837^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:9676195^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0003303	BMP signaling pathway involved in heart jogging	PMID:9334285^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1043	P	Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000932177 UniProtKB:P22003 UniProtKB:P22004	F	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:88182 PANTHER:PTN000932177 UniProtKB:P18075 UniProtKB:P22004	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Little, SC & Mullins, MC (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11 637-43 PubMed GONUTS page
↑ ^2.0 ^2.1 Hogan, BM et al. (2006) Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr. Biol. 16 506-11 PubMed GONUTS page
↑ Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page
↑ Imai, Y & Talbot, WS (2001) Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Genesis 30 160-3 PubMed GONUTS page
↑ ^5.0 ^5.1 Bauer, H et al. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 128 849-58 PubMed GONUTS page
↑ Poulain, M et al. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development 133 2189-200 PubMed GONUTS page
↑ Yang, Y & Thorpe, C (2011) BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish. Development 138 2601-11 PubMed GONUTS page
↑ ^8.0 ^8.1 Nguyen, VH et al. (1998) Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev. Biol. 199 93-110 PubMed GONUTS page
↑ Guo, S et al. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron 24 555-66 PubMed GONUTS page
↑ ^10.0 ^10.1 Grinblat, Y & Sive, H (2001) zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Dev. Dyn. 222 688-93 PubMed GONUTS page
↑ Wagner, DS & Mullins, MC (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev. Biol. 245 109-23 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19377468-1] 1.0 ^1.1 ^1.2 ^1.3 Little, SC & Mullins, MC (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11 637-43 PubMed GONUTS page

[PMID:16527746-2] 2.0 ^2.1 Hogan, BM et al. (2006) Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr. Biol. 16 506-11 PubMed GONUTS page

[PMID:12601179-3] Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page

[PMID:11477698-4] Imai, Y & Talbot, WS (2001) Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Genesis 30 160-3 PubMed GONUTS page

[PMID:11222140-5] 5.0 ^5.1 Bauer, H et al. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 128 849-58 PubMed GONUTS page

[PMID:16672336-6] Poulain, M et al. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development 133 2189-200 PubMed GONUTS page

[PMID:21610036-7] Yang, Y & Thorpe, C (2011) BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish. Development 138 2601-11 PubMed GONUTS page

[PMID:9676195-8] 8.0 ^8.1 Nguyen, VH et al. (1998) Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev. Biol. 199 93-110 PubMed GONUTS page

[PMID:10595509-9] Guo, S et al. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron 24 555-66 PubMed GONUTS page

[PMID:11748837-10] 10.0 ^10.1 Grinblat, Y & Sive, H (2001) zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Dev. Dyn. 222 688-93 PubMed GONUTS page

[PMID:11969259-11] Wagner, DS & Mullins, MC (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev. Biol. 245 109-23 PubMed GONUTS page

[PMID:9334285-12] 12.0 ^12.1 ^12.2 ^12.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:Q9PTF9

Contents

Annotations

Notes

References

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