MOUSE:BMP7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bmp7 (synonyms: Bmp-7, Op1)
Protein Name(s)	Bone morphogenetic protein 7 BMP-7 Osteogenic protein 1 OP-1
External Links
UniProt	P23359
EMBL	X56906 BC010771
CCDS	CCDS17136.1
PIR	JQ1184
RefSeq	NP_031583.2
UniGene	Mm.392150 Mm.595
ProteinModelPortal	P23359
SMR	P23359
BioGrid	198367
PhosphoSite	P23359
PRIDE	P23359
Ensembl	ENSMUST00000009143
GeneID	12162
KEGG	mmu:12162
UCSC	uc008odb.2
CTD	655
MGI	MGI:103302
eggNOG	NOG272883
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249476
HOVERGEN	HBG004860
InParanoid	P23359
KO	K16621
OMA	HKEFRFD
OrthoDB	EOG7J9VPQ
PhylomeDB	P23359
TreeFam	TF316134
Reactome	REACT_198998
NextBio	280515
PRO	PR:P23359
Proteomes	UP000000589
Bgee	P23359
CleanEx	MM_BMP7
Genevestigator	P23359
GO	GO:0031012 GO:0005615 GO:0031988 GO:0070700 GO:0005125 GO:0008201 GO:0048646 GO:0007411 GO:0030509 GO:0060445 GO:0048754 GO:0048593 GO:0051216 GO:0048468 GO:0048596 GO:0030326 GO:0009880 GO:0060272 GO:0030855 GO:0001654 GO:0040007 GO:0001822 GO:0048762 GO:0060485 GO:0001707 GO:0072136 GO:0072133 GO:0070487 GO:0008285 GO:0072125 GO:0043407 GO:0072040 GO:0045839 GO:0050768 GO:0045665 GO:0045746 GO:0042326 GO:0060686 GO:0045892 GO:0072134 GO:0048812 GO:0042475 GO:0009887 GO:0001503 GO:0007389 GO:0043065 GO:0030501 GO:0010942 GO:0045597 GO:1900006 GO:0034116 GO:1900106 GO:0045666 GO:0045669 GO:0010862 GO:0010800 GO:0045944 GO:0034504 GO:0060687 GO:0032355 GO:0043434 GO:0033280 GO:0007435 GO:0060395 GO:0043401 GO:0035239 GO:0001657
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003416	endochondral bone growth	PMID:23539268^[1]	ECO:0000316		PMID:23539268^[1]	P		Figure 1 shows response of cells to bone morphology protein.	complete CACAO 7878
involved_in	GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	PMID:23863481^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0061384	heart trabecula morphogenesis	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:1905069	allantois development	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:10079236^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:23863481^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21275	P	occurs_in:(UBERON:0004145)	Seeded From UniProt	complete
involved_in	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	PMID:15342483^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0072134	nephrogenic mesenchyme morphogenesis	PMID:15342483^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0072133	metanephric mesenchyme morphogenesis	PMID:15342483^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0072125	negative regulation of glomerular mesangial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	PMID:9693150^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:15342483^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:16154126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:9693150^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:16154126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000932177 UniProtKB:P22003 UniProtKB:P22004	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:88182 PANTHER:PTN000932177 UniProtKB:P18075 UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900106	positive regulation of hyaluranon cable assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900006	positive regulation of dendrite development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072125	negative regulation of glomerular mesangial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	PMID:9056639^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	regulates_o_occurs_in:(EMAPA:17373) regulates_o_occurs_in:(CL:0000383)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:7811286^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22004	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070487	monocyte aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620743	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060687	regulation of branching involved in prostate gland morphogenesis	PMID:16324690^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	regulates_o_occurs_in:(EMAPA:36568)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060687	regulation of branching involved in prostate gland morphogenesis	PMID:16324690^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	regulates_o_occurs_in:(EMAPA:29794)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060686	negative regulation of prostatic bud formation	PMID:16324690^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:11731698^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	has_participant:(EMAPA:18813)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060272	embryonic skeletal joint morphogenesis	PMID:9664686^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060272	embryonic skeletal joint morphogenesis	PMID:9664686^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934010	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	PMID:17699604^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:16069)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	PMID:16325379^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	PMID:16325379^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048762	mesenchymal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	PMID:15831470^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:17878916^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	results_in_formation_of:(EMAPA:18692)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:16854970^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	results_in_formation_of:(EMAPA:17166)\|results_in_formation_of:(EMAPA:18238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:10049573^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	results_in_formation_of:(EMAPA:16799)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048596	embryonic camera-type eye morphogenesis	PMID:10049573^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	has_participant:(EMAPA:16799)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:16854970^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	has_participant:(EMAPA:17166)\|has_participant:(EMAPA:18238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:16154126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	has_participant:(EMAPA:16198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:15831470^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16801560^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1276116 MGI:MGI:1919200	P	has_regulation_target:(MGI:MGI:98472)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045839	negative regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	PMID:16324690^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:9786991^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:16325379^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:16325379^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:15525533^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17919) regulates_o_results_in_acquisition_of_features_of:(CL:0000059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:16854970^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	occurs_in:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:15525533^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17919)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042326	negative regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042325	regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620743	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035239	tube morphogenesis	PMID:15831470^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620743	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:17878916^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	occurs_in:(EMAPA:18692) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:14623234^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:9664686^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:9664686^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934010	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:7590254^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:10049573^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16539)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16854970^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	regulates_o_occurs_in:(EMAPA:16674)	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620743	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007435	salivary gland morphogenesis	PMID:11731698^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P	has_participant:(EMAPA:18813)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:12741987^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:7590254^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857654	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12741987^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18075	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620743	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:16154126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136986	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:15843411^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137520	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
involved_in	GO:1900106	positive regulation of hyaluranon cable assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0072125	negative regulation of glomerular mesangial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0070487	monocyte aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	C		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18075 ensembl:ENSP00000379204	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:7590254^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen, BL et al. (2013) Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis in Schistosoma japonicum-infected mice via transforming growth factor-β/Smad signaling. World J. Gastroenterol. 19 1405-15 PubMed GONUTS page
↑ ^2.0 ^2.1 Bai, Y et al. (2013) Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140 3395-402 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Solloway, MJ & Robertson, EJ (1999) Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126 1753-68 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Oxburgh, L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131 4593-605 PubMed GONUTS page
↑ ^5.0 ^5.1 Godin, RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125 3473-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Oxburgh, L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev. Biol. 286 637-46 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dudley, AT & Robertson, EJ (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev. Dyn. 208 349-62 PubMed GONUTS page
↑ Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Grishina, IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev. Biol. 288 334-47 PubMed GONUTS page
↑ ^11.0 ^11.1 Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Katagiri, T et al. (1998) Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev. Genet. 22 340-8 PubMed GONUTS page
↑ Di-Gregorio, A et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134 3359-69 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Krizhanovsky, V & Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123 67-75 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Leung-Hagesteijn, C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol. Cell. Biol. 25 3648-57 PubMed GONUTS page
↑ ^16.0 ^16.1 Suzuki, K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur. J. Hum. Genet. 16 36-44 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Morcillo, J et al. (2006) Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development 133 3179-90 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Wawersik, S et al. (1999) BMP7 acts in murine lens placode development. Dev. Biol. 207 176-88 PubMed GONUTS page
↑ Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page
↑ Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page
↑ ^21.0 ^21.1 Wang, XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev. Cell 7 719-30 PubMed GONUTS page
↑ Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Dudley, AT et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9 2795-807 PubMed GONUTS page
↑ ^24.0 ^24.1 Butler, SJ & Dodd, J (2003) A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 38 389-401 PubMed GONUTS page
↑ Zakin, L et al. (2005) Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development 132 2489-99 PubMed GONUTS page

[PMID:23539268-1] 1.0 ^1.1 Chen, BL et al. (2013) Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis in Schistosoma japonicum-infected mice via transforming growth factor-β/Smad signaling. World J. Gastroenterol. 19 1405-15 PubMed GONUTS page

[PMID:23863481-2] 2.0 ^2.1 Bai, Y et al. (2013) Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140 3395-402 PubMed GONUTS page

[PMID:10079236-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Solloway, MJ & Robertson, EJ (1999) Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126 1753-68 PubMed GONUTS page

[PMID:15342483-4] 4.0 ^4.1 ^4.2 ^4.3 Oxburgh, L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131 4593-605 PubMed GONUTS page

[PMID:9693150-5] 5.0 ^5.1 Godin, RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125 3473-82 PubMed GONUTS page

[PMID:16154126-6] 6.0 ^6.1 ^6.2 ^6.3 Oxburgh, L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev. Biol. 286 637-46 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9056639-8] Dudley, AT & Robertson, EJ (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev. Dyn. 208 349-62 PubMed GONUTS page

[PMID:7811286-9] Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

[PMID:16324690-10] 10.0 ^10.1 ^10.2 ^10.3 Grishina, IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev. Biol. 288 334-47 PubMed GONUTS page

[PMID:11731698-11] 11.0 ^11.1 Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page

[PMID:9664686-12] 12.0 ^12.1 ^12.2 ^12.3 Katagiri, T et al. (1998) Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev. Genet. 22 340-8 PubMed GONUTS page

[PMID:17699604-13] Di-Gregorio, A et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134 3359-69 PubMed GONUTS page

[PMID:16325379-14] 14.0 ^14.1 ^14.2 ^14.3 Krizhanovsky, V & Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123 67-75 PubMed GONUTS page

[PMID:15831470-15] 15.0 ^15.1 ^15.2 Leung-Hagesteijn, C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol. Cell. Biol. 25 3648-57 PubMed GONUTS page

[PMID:17878916-16] 16.0 ^16.1 Suzuki, K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur. J. Hum. Genet. 16 36-44 PubMed GONUTS page

[PMID:16854970-17] 17.0 ^17.1 ^17.2 ^17.3 Morcillo, J et al. (2006) Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development 133 3179-90 PubMed GONUTS page

[PMID:10049573-18] 18.0 ^18.1 ^18.2 Wawersik, S et al. (1999) BMP7 acts in murine lens placode development. Dev. Biol. 207 176-88 PubMed GONUTS page

[PMID:16801560-19] Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page

[PMID:9786991-20] Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page

[PMID:15525533-21] 21.0 ^21.1 Wang, XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev. Cell 7 719-30 PubMed GONUTS page

[PMID:14623234-22] Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page

[PMID:7590254-23] 23.0 ^23.1 ^23.2 Dudley, AT et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9 2795-807 PubMed GONUTS page

[PMID:12741987-24] 24.0 ^24.1 Butler, SJ & Dodd, J (2003) A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 38 389-401 PubMed GONUTS page

[PMID:15843411-25] Zakin, L et al. (2005) Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development 132 2489-99 PubMed GONUTS page

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MOUSE:BMP7

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