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PMID:16325379

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Citation

Krizhanovsky, V and Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123:67-75

Abstract

Cerebellar granule cells, the most abundant neurons in the mammalian brain, arise in the rhombic lip located at the roof of the brain's fourth ventricle. Bordering the rhombic lip is the choroid plexus, a non-neuronal structure, composed of blood vessels enveloped by epithelial cells. Here, we show a striking decrease in neural differentiation of rhombic lip-derived cells, which failed to extend neuritic processes and attenuate Math1 promoter activity, when co-cultured with choroid plexus cells. Moreover, a blocking antibody against BMP7, a morphogenetic protein expressed in the choroid plexus, blocked the inhibitory effect of the choroid plexus, whereas purified BMP7 mimicked this effect, demonstrating causal involvement of BMP. On the other hand, the BMP antagonist NBL1 promoted neurogenesis in rhombic lip cultures from Math1 null mice displaying arrested differentiation. Our data indicate that besides its secretory and barrier functions, the choroid plexus has a novel role in attenuating the differentiation of adjacent neural progenitors.

Links

PubMed Online version:10.1016/j.mod.2005.09.005

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors/deficiency; Basic Helix-Loop-Helix Transcription Factors/genetics; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins/metabolism; Cell Differentiation; Cerebellum/cytology; Cerebellum/embryology; Cerebellum/metabolism; Choroid Plexus/embryology; Choroid Plexus/metabolism; Gene Expression Regulation, Developmental; Mice; Mice, Knockout; Models, Neurological; Multipotent Stem Cells/cytology; Multipotent Stem Cells/metabolism; Neurons/cytology; Neurons/metabolism; Proteins/genetics; Proteins/metabolism; Transforming Growth Factor beta/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BMP7

acts_upstream_of_or_within

GO:0045665: negative regulation of neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP7

acts_upstream_of_or_within

GO:0048812: neuron projection morphogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP7

involved_in

GO:0045665: negative regulation of neuron differentiation

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P18075

P

Seeded From UniProt

complete

MOUSE:BMP7

involved_in

GO:0048812: neuron projection morphogenesis

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P18075

P

Seeded From UniProt

complete

MOUSE:BMP7

involved_in

GO:0045665: negative regulation of neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP7

involved_in

GO:0048812: neuron projection morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ATOH1

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2155983

P

Seeded From UniProt

complete

MOUSE:ATOH1

involved_in

GO:0021987: cerebral cortex development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2155983

P

Seeded From UniProt

complete

MOUSE:NBL1

involved_in

GO:0045666: positive regulation of neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:NBL1

involved_in

GO:0048812: neuron projection morphogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:NBL1

involved_in

GO:0030182: neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP7

involved_in

GO:0045665: negative regulation of neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP7

involved_in

GO:0048812: neuron projection morphogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP7

acts_upstream_of_or_within

GO:0048812: neuron projection morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP7

acts_upstream_of_or_within

GO:0048812: neuron projection morphogenesis

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P18075

P

Seeded From UniProt

complete

MOUSE:BMP7

acts_upstream_of_or_within

GO:0045665: negative regulation of neuron differentiation

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P18075

P

Seeded From UniProt

complete

MOUSE:BMP7

acts_upstream_of_or_within

GO:0045665: negative regulation of neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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