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PMID:7590254
| Citation |
Dudley, AT, Lyons, KM and Robertson, EJ (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9:2795-807 |
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| Abstract |
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development. |
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| Keywords |
Animals; Base Sequence; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; DNA Primers; Eye/growth & development; Female; Kidney/growth & development; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Proteins/metabolism; Transforming Growth Factor beta/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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