CHICK:TGFB2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	TGFB2
Protein Name(s)	Transforming growth factor beta-2 TGF-beta-2 Latency-associated peptide LAP
External Links
UniProt	P30371
EMBL	X58071 X59082 X59081 X59080
PIR	A39489
UniGene	Gga.8797
ProteinModelPortal	P30371
SMR	P30371
PaxDb	P30371
eggNOG	NOG269146
HOGENOM	HOG000290198
HOVERGEN	HBG074115
InParanoid	P30371
PhylomeDB	P30371
NextBio	20824129
PRO	PR:P30371
Proteomes	UP000000539
GO	GO:0030424 GO:0031012 GO:0005576 GO:0005615 GO:0043025 GO:0001540 GO:0042803 GO:0005102 GO:0004702 GO:0005160 GO:0005114 GO:0032147 GO:0060317 GO:0060038 GO:0010002 GO:0051216 GO:0007050 GO:0008219 GO:0016049 GO:0016477 GO:0000902 GO:0045216 GO:0030199 GO:0042416 GO:0009790 GO:0009792 GO:0048566 GO:0042118 GO:0001837 GO:0003198 GO:0097191 GO:0001654 GO:0008347 GO:0008406 GO:0007507 GO:0003007 GO:0030097 GO:0030324 GO:0010693 GO:0007162 GO:0008285 GO:0050680 GO:0010936 GO:0007399 GO:0021915 GO:0048666 GO:0030593 GO:0048513 GO:0060389 GO:0051891 GO:0051795 GO:0033630 GO:0045787 GO:0051781 GO:0030307 GO:0008284 GO:0010634 GO:0010718 GO:0045823 GO:0050778 GO:0045726 GO:0043525 GO:0014068 GO:0050714 GO:0032874 GO:0006468 GO:0045595 GO:0042127 GO:0040008 GO:0032909 GO:0042493 GO:0001666 GO:0032570 GO:0023014 GO:0007519 GO:0007184 GO:0048103 GO:0001756 GO:0048536 GO:0007179 GO:0042060
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR016319 IPR015615 IPR003940 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PIRSF	PIRSF001787
PRINTS	PR01423 PR01425
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1903659	regulation of complement-dependent cytotoxicity	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0051891	positive regulation of cardioblast differentiation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045823	positive regulation of heart contraction	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045726	positive regulation of integrin biosynthetic process	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010693	negative regulation of alkaline phosphatase activity	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010002	cardioblast differentiation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008347	glial cell migration	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060416	response to growth hormone	PMID:15039987^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060390	regulation of SMAD protein signal transduction	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	PMID:11884076^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:11884076^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:8167376^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:10401723^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:10401723^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10401723^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812-2	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812-2	F	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	PMID:9151404^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	PMID:9151404^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:16870219^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:17587820^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	PMID:16870219^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:8167376^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	PMID:15828015^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:16870219^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:8167376^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	PMID:16870219^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:15828015^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:8167376^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0051891	positive regulation of cardioblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0051795	positive regulation of timing of catagen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0050778	positive regulation of immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09858	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	P	Seeded From UniProt	complete
involved_in	GO:0048103	somatic stem cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	P	Seeded From UniProt	complete
involved_in	GO:0045823	positive regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	P	Seeded From UniProt	complete
involved_in	GO:0045726	positive regulation of integrin biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0042416	dopamine biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6T7C3	P	Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032874	positive regulation of stress-activated MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09858	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	C	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27090	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010693	negative regulation of alkaline phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0010002	cardioblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008347	glial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61812	P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003940	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016319	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:18461597^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:17587820^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:15828015^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048513	animal organ development	PMID:16870219^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:15828015^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008406	gonad development	PMID:15828015^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	PMID:15828015^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:12704694^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	PMID:17587820^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 Barbour, EK et al. (1999) Dynamics of protein 27 of avian leukosis virus and transforming growth factor beta2 in lymphoid leukosis susceptible and resistant broiler chicken breeding stock. Vet. Res. Commun. 23 191-200 PubMed GONUTS page
↑ Fujioka, T et al. (2004) Function of TGF-beta2 in the growth of chicken primordial germ cells and germinal ridge stroma cells during embryonic development. J. Exp. Zoolog. Part A Comp. Exp. Biol. 301 290-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Hattori Ma, MA et al. (2002) Prominent expression of transforming growth factor beta2 gene in the chicken embryonic gonad as revealed by suppressive subtraction cloning. Gen. Comp. Endocrinol. 125 311-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Barnett, JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev. Dyn. 199 12-27 PubMed GONUTS page
↑ ^5.0 ^5.1 Jakowlew, SB et al. (1997) Transforming growth factor-beta isoforms in the developing chicken intestine and spleen: increase in transforming growth factor-beta 4 with coccidia infection. Vet. Immunol. Immunopathol. 55 321-39 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Saxena, VK et al. (2007) Temporal expression of transforming growth factor-beta2 and myostatin mRNA during embryonic myogenesis in Indian broilers. Res. Vet. Sci. 82 50-3 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Mercado-Pimentel, ME & Runyan, RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs (Print) 185 146-56 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Aramaki, S et al. (2005) Temporal and spatial expression of TGF-beta2 in chicken somites during early embryonic development. J. Exp. Zoolog. Part A Comp. Exp. Biol. 303 323-30 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sakabe, M et al. (2008) ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation. Anat Rec (Hoboken) 291 845-57 PubMed GONUTS page
↑ Olivey, HE et al. (2003) Expression of the type III TGFbeta receptor during chick organogenesis. Anat Rec A Discov Mol Cell Evol Biol 272 383-7 PubMed GONUTS page

[PMID:10401723-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 Barbour, EK et al. (1999) Dynamics of protein 27 of avian leukosis virus and transforming growth factor beta2 in lymphoid leukosis susceptible and resistant broiler chicken breeding stock. Vet. Res. Commun. 23 191-200 PubMed GONUTS page

[PMID:15039987-2] Fujioka, T et al. (2004) Function of TGF-beta2 in the growth of chicken primordial germ cells and germinal ridge stroma cells during embryonic development. J. Exp. Zoolog. Part A Comp. Exp. Biol. 301 290-6 PubMed GONUTS page

[PMID:11884076-3] 3.0 ^3.1 Hattori Ma, MA et al. (2002) Prominent expression of transforming growth factor beta2 gene in the chicken embryonic gonad as revealed by suppressive subtraction cloning. Gen. Comp. Endocrinol. 125 311-6 PubMed GONUTS page

[PMID:8167376-4] 4.0 ^4.1 ^4.2 ^4.3 Barnett, JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev. Dyn. 199 12-27 PubMed GONUTS page

[PMID:9151404-5] 5.0 ^5.1 Jakowlew, SB et al. (1997) Transforming growth factor-beta isoforms in the developing chicken intestine and spleen: increase in transforming growth factor-beta 4 with coccidia infection. Vet. Immunol. Immunopathol. 55 321-39 PubMed GONUTS page

[PMID:16870219-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Saxena, VK et al. (2007) Temporal expression of transforming growth factor-beta2 and myostatin mRNA during embryonic myogenesis in Indian broilers. Res. Vet. Sci. 82 50-3 PubMed GONUTS page

[PMID:17587820-7] 7.0 ^7.1 ^7.2 Mercado-Pimentel, ME & Runyan, RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs (Print) 185 146-56 PubMed GONUTS page

[PMID:15828015-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Aramaki, S et al. (2005) Temporal and spatial expression of TGF-beta2 in chicken somites during early embryonic development. J. Exp. Zoolog. Part A Comp. Exp. Biol. 303 323-30 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18461597-10] Sakabe, M et al. (2008) ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation. Anat Rec (Hoboken) 291 845-57 PubMed GONUTS page

[PMID:12704694-11] Olivey, HE et al. (2003) Expression of the type III TGFbeta receptor during chick organogenesis. Anat Rec A Discov Mol Cell Evol Biol 272 383-7 PubMed GONUTS page

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CHICK:TGFB2

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