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CHICK:SMAD5

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) SMAD5 (synonyms: MADH5)
Protein Name(s) Mothers against decapentaplegic homolog 5

MAD homolog 5 Mothers against DPP homolog 5 SMAD family member 5 SMAD 5 Smad5

External Links
UniProt Q56I99
EMBL AY953144
RefSeq NP_001014968.1
UniGene Gga.44385
Gga.50148
ProteinModelPortal Q56I99
SMR Q56I99
STRING 9031.ENSGALP00000039387
PaxDb Q56I99
Ensembl ENSGALT00000040187
GeneID 395679
KEGG gga:395679
CTD 4090
eggNOG NOG330956
GeneTree ENSGT00760000119091
HOGENOM HOG000286018
HOVERGEN HBG053353
InParanoid Q56I99
KO K16790
OMA DVQPVEY
PhylomeDB Q56I99
Reactome REACT_251716
NextBio 20815751
PRO PR:Q56I99
Proteomes UP000000539
GO GO:0005737
GO:0005634
GO:0005667
GO:0046872
GO:0000979
GO:0003700
GO:0060348
GO:0060048
GO:0051216
GO:0071773
GO:0071407
GO:0030218
GO:0007281
GO:0002051
GO:0045669
GO:1901522
GO:0006468
GO:0006351
GO:0007179
GO:0001657
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:20071511[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002295)
  • part_of:(CL:0000202)|part_of:(UBERON:0002295)
  • part_of:(CL:0005014)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21308853[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000023)

Seeded From UniProt

complete

involved_in

GO:1901522

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0071773

cellular response to BMP stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060348

bone development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060048

cardiac muscle contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0007281

germ cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

C

Seeded From UniProt

complete

involved_in

GO:0002051

osteoblast fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q68DB7
ensembl:ENSP00000441954

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q68DB7
ensembl:ENSP00000441954

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99717
ensembl:ENSP00000441954

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99717
ensembl:ENSP00000441954

F

Seeded From UniProt

complete

enables

GO:0017151

DEAD/H-box RNA helicase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99717
ensembl:ENSP00000441954

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99717
ensembl:ENSP00000441954

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99717
ensembl:ENSP00000441954

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019
InterPro:IPR036578

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page
  2. ↑ Diaz, FJ et al. (2011) Early avian follicular development is characterized by changes in transcripts involved in steroidogenesis, paracrine signaling and transcription. Mol. Reprod. Dev. 78 212-23 PubMed GONUTS page
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