HUMAN:NODAL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NODAL
Protein Name(s)	Nodal homolog
External Links
UniProt	Q96S42
EMBL	AB067632 AC022532 BC033585 BC104976 BC112025
CCDS	CCDS7304.1
RefSeq	NP_060525.3
UniGene	Hs.370414
PDB	4N1D
PDBsum	4N1D
ProteinModelPortal	Q96S42
SMR	Q96S42
STRING	9606.ENSP00000287139
DMDM	166214958
PaxDb	Q96S42
PRIDE	Q96S42
Ensembl	ENST00000287139
GeneID	4838
KEGG	hsa:4838
UCSC	uc001jrc.2
CTD	4838
GeneCards	GC10M072191
GeneReviews	NODAL
H-InvDB	HIX0008897
HGNC	HGNC:7865
HPA	HPA045201
MIM	270100 601265
neXtProt	NX_Q96S42
Orphanet	93925 93924 280200 93926 220386 280195 157769 101063
PharmGKB	PA31669
eggNOG	NOG278576
GeneTree	ENSGT00740000114888
HOGENOM	HOG000113815
HOVERGEN	HBG108195
InParanoid	Q96S42
KO	K04666
OMA	EVDGQNW
OrthoDB	EOG7DFXD1
PhylomeDB	Q96S42
TreeFam	TF316134
Reactome	REACT_111057 REACT_111059
SignaLink	Q96S42
GeneWiki	NODAL
GenomeRNAi	4838
NextBio	18642
PRO	PR:Q96S42
Proteomes	UP000005640
Bgee	Q96S42
CleanEx	HS_NODAL
ExpressionAtlas	Q96S42
Genevestigator	Q96S42
GO	GO:0005615 GO:0016015 GO:0070698 GO:0048327 GO:0007420 GO:0042074 GO:0048546 GO:0048701 GO:0009880 GO:0001892 GO:0060136 GO:0035987 GO:0060802 GO:0033505 GO:0048859 GO:0040007 GO:0001947 GO:0002085 GO:0060460 GO:0001889 GO:0001893 GO:0060137 GO:0048382 GO:0060766 GO:1901383 GO:0000122 GO:1901164 GO:0001842 GO:1900164 GO:0001890 GO:0010085 GO:0032927 GO:0045766 GO:0022409 GO:0043280 GO:0050679 GO:0070374 GO:1900224 GO:0010862 GO:0051091 GO:0060391 GO:0045944 GO:0010575 GO:0010470 GO:2000036 GO:0060395 GO:0019827 GO:0090010 GO:0001831 GO:0001944
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901383	negative regulation of chorionic trophoblast cell proliferation	PMID:15150278^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901164	negative regulation of trophoblast cell migration	PMID:21356369^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91619	P		Seeded From UniProt	complete
enables	GO:0070698	type I activin receptor binding	PMID:21356369^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21116837^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	PMID:21656830^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:21741376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:21116837^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16665)	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:21656830^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	PMID:21741376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21116837^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:15150278^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000351)	Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	PMID:21741376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032927	positive regulation of activin receptor signaling pathway	PMID:15150278^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8NER5	P		Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	PMID:21116837^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:21159651^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21741376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:21116837^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21656830^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	PMID:21356369^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070698	type I activin receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218276 UniProtKB:Q96S42	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95689 MGI:MGI:95690 PANTHER:PTN000218210 RGD:2211 UniProtKB:O95393 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0090010	transforming growth factor beta receptor signaling pathway involved in primitive streak formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0090009	primitive streak formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0060802	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0060460	left lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0060136	embryonic process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0055123	digestive system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048859	formation of anatomical boundary	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048729	tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0048327	axial mesodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0038092	nodal signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0033505	floor plate morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0010721	negative regulation of cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0010470	regulation of gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0010085	polarity specification of proximal/distal axis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	C		Seeded From UniProt	complete
involved_in	GO:0002085	inhibition of neuroepithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001893	maternal placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001842	neural fold formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001831	trophectodermal cellular morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001829	trophectodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43021 ensembl:ENSMUSP00000039653	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
involved_in	GO:2000036	regulation of stem cell population maintenance	PMID:21630377^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

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↑ ^1.0 ^1.1 ^1.2 Munir, S et al. (2004) Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J. Biol. Chem. 279 31277-86 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Nadeem, L et al. (2011) Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am. J. Pathol. 178 1177-89 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hueng, DY et al. (2011) Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. J. Neurooncol. 104 21-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lawrence, MG et al. (2011) Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate 71 1198-209 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kim, SW et al. (2011) Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev. Biol. 357 492-504 PubMed GONUTS page
↑ Hardy, KM et al. (2010) Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res. 70 10340-50 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Brown, S et al. (2011) Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 29 1176-85 PubMed GONUTS page

[PMID:15150278-1] 1.0 ^1.1 ^1.2 Munir, S et al. (2004) Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J. Biol. Chem. 279 31277-86 PubMed GONUTS page

[PMID:21356369-2] 2.0 ^2.1 ^2.2 Nadeem, L et al. (2011) Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am. J. Pathol. 178 1177-89 PubMed GONUTS page

[PMID:21116837-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hueng, DY et al. (2011) Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. J. Neurooncol. 104 21-31 PubMed GONUTS page

[PMID:21656830-4] 4.0 ^4.1 ^4.2 Lawrence, MG et al. (2011) Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate 71 1198-209 PubMed GONUTS page

[PMID:21741376-5] 5.0 ^5.1 ^5.2 ^5.3 Kim, SW et al. (2011) Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev. Biol. 357 492-504 PubMed GONUTS page

[PMID:21159651-6] Hardy, KM et al. (2010) Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res. 70 10340-50 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21630377-8] Brown, S et al. (2011) Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 29 1176-85 PubMed GONUTS page

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