HUMAN:BMP7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BMP7 (synonyms: OP1)
Protein Name(s)	Bone morphogenetic protein 7 BMP-7 Osteogenic protein 1 OP-1
External Links
UniProt	P18075
EMBL	X51801 M60316 AL122058 AL157414 AL157414 AL122058 BC008584
CCDS	CCDS13455.1
PIR	C39263
RefSeq	NP_001710.1
UniGene	Hs.473163
PDB	1BMP 1LX5 1LXI 1M4U
PDBsum	1BMP 1LX5 1LXI 1M4U
ProteinModelPortal	P18075
SMR	P18075
BioGrid	107123
DIP	DIP-5800N
IntAct	P18075
MINT	MINT-263199
STRING	9606.ENSP00000379204
PhosphoSite	P18075
DMDM	115078
MaxQB	P18075
PaxDb	P18075
PRIDE	P18075
DNASU	655
Ensembl	ENST00000395863
GeneID	655
KEGG	hsa:655
UCSC	uc010gip.1
CTD	655
GeneCards	GC20M055743
HGNC	HGNC:1074
MIM	112267
neXtProt	NX_P18075
PharmGKB	PA25384
eggNOG	NOG272883
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249476
HOVERGEN	HBG004860
InParanoid	P18075
KO	K16621
OMA	HKEFRFD
OrthoDB	EOG7J9VPQ
PhylomeDB	P18075
TreeFam	TF316134
Reactome	REACT_150331
SignaLink	P18075
ChiTaRS	BMP7
EvolutionaryTrace	P18075
GeneWiki	Bone_morphogenetic_protein_7
GenomeRNAi	655
NextBio	2664
PRO	PR:P18075
Proteomes	UP000005640
Bgee	P18075
CleanEx	HS_BMP7
ExpressionAtlas	P18075
Genevestigator	P18075
GO	GO:0031012 GO:0005576 GO:0005615 GO:0031988 GO:0008201 GO:0007411 GO:0030509 GO:0060445 GO:0048754 GO:0051216 GO:0071456 GO:0016358 GO:0048596 GO:0030326 GO:0009880 GO:0060272 GO:0030855 GO:0001837 GO:0030198 GO:0040007 GO:0048762 GO:0060485 GO:0001707 GO:0001823 GO:0072136 GO:0072133 GO:0001656 GO:0070487 GO:0045786 GO:0060548 GO:0072125 GO:0043407 GO:0072040 GO:0045839 GO:0045665 GO:0042347 GO:0032088 GO:0045746 GO:0042326 GO:0060686 GO:0010664 GO:0045892 GO:0072134 GO:0048812 GO:0042475 GO:0001503 GO:0043065 GO:0030501 GO:1900006 GO:0034116 GO:1900106 GO:0045669 GO:0010862 GO:0010800 GO:0045944 GO:0045893 GO:0034504 GO:0060687 GO:0060393 GO:2000121 GO:0032355 GO:0043434 GO:0033280 GO:0001501 GO:0060395 GO:0043401 GO:0001657
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:28124060^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000199161) occurs_in:(CL:1000413) occurs_in:(UBERON:0001621)\|regulates_expression_of(ENSEMBL:ENSG00000199161) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:1905069	allantois development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0061384	heart trabecula morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:2000121	regulation of removal of superoxide radicals	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R228	P		Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	PMID:11580864^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000111)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R228	P		Seeded From UniProt	complete
involved_in	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	PMID:16049014^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16049014^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R228	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R228	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:16049014^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:19736306^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:9311995^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:16049014^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:19736306^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P17813)	Seeded From UniProt	complete
involved_in	GO:0010664	negative regulation of striated muscle cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R228	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14517293^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:11502704^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900106	positive regulation of hyaluranon cable assembly	PMID:15100360^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072125	negative regulation of glomerular mesangial cell proliferation	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070487	monocyte aggregation	PMID:15100360^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:12631064^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	PMID:9693150^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15100360^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q92819)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15100360^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q12794)\|has_regulation_target:(UniProtKB:Q12891)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	PMID:17244894^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:15100360^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:17244894^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17977014^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	PMID:18437684^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23359	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	PMID:18437684^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000932177 UniProtKB:P22003 UniProtKB:P22004	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:88182 PANTHER:PTN000932177 UniProtKB:P18075 UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:16325379^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	PMID:16325379^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6W8 ensembl:ENSRNOP00000070891	C		Seeded From UniProt	complete
involved_in	GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:1905069	allantois development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0072134	nephrogenic mesenchyme morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0072133	metanephric mesenchyme morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0061384	heart trabecula morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060687	regulation of branching involved in prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060686	negative regulation of prostatic bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060272	embryonic skeletal joint morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048593	camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0035239	tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	C		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23359 ensembl:ENSMUSP00000009143	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:2357959^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	PMID:11580864^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000111)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:11580864^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797) happens_during:(GO:0016358)	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:14679171^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2396399	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page
↑ ^2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Beck, HN et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci 2 12 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Mazerbourg, S et al. (2005) Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J. Biol. Chem. 280 32122-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
↑ ^6.0 ^6.1 Romero, D et al. (2010) Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis 31 359-66 PubMed GONUTS page
↑ Nakao, A et al. (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16 5353-62 PubMed GONUTS page
↑ Rebbapragada, A et al. (2003) Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23 7230-42 PubMed GONUTS page
↑ Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Selbi, W et al. (2004) BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction. J. Am. Soc. Nephrol. 15 1199-211 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Otani, H et al. (2007) Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am. J. Physiol. Renal Physiol. 292 F1513-25 PubMed GONUTS page
↑ Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page
↑ Godin, RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125 3473-82 PubMed GONUTS page
↑ Swencki-Underwood, B et al. (2008) Expression and characterization of a human BMP-7 variant with improved biochemical properties. Protein Expr. Purif. 57 312-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^17.0 ^17.1 Krizhanovsky, V & Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123 67-75 PubMed GONUTS page
↑ Ozkaynak, E et al. (1990) OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J. 9 2085-93 PubMed GONUTS page
↑ Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page

[PMID:28124060-1] Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page

[PMID:18326817-2] 2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page

[PMID:11580864-3] 3.0 ^3.1 ^3.2 Beck, HN et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci 2 12 PubMed GONUTS page

[PMID:16049014-4] 4.0 ^4.1 ^4.2 ^4.3 Mazerbourg, S et al. (2005) Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J. Biol. Chem. 280 32122-32 PubMed GONUTS page

[PMID:18436533-5] 5.0 ^5.1 ^5.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page

[PMID:19736306-6] 6.0 ^6.1 Romero, D et al. (2010) Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis 31 359-66 PubMed GONUTS page

[PMID:9311995-7] Nakao, A et al. (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16 5353-62 PubMed GONUTS page

[PMID:14517293-8] Rebbapragada, A et al. (2003) Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23 7230-42 PubMed GONUTS page

[PMID:11502704-9] Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page

[PMID:15100360-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Selbi, W et al. (2004) BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction. J. Am. Soc. Nephrol. 15 1199-211 PubMed GONUTS page

[PMID:17244894-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Otani, H et al. (2007) Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am. J. Physiol. Renal Physiol. 292 F1513-25 PubMed GONUTS page

[PMID:12631064-12] Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page

[PMID:9693150-13] Godin, RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125 3473-82 PubMed GONUTS page

[PMID:17977014-14] Swencki-Underwood, B et al. (2008) Expression and characterization of a human BMP-7 variant with improved biochemical properties. Protein Expr. Purif. 57 312-9 PubMed GONUTS page

[PMID:18437684-15] 15.0 ^15.1 Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16325379-17] 17.0 ^17.1 Krizhanovsky, V & Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123 67-75 PubMed GONUTS page

[PMID:2357959-18] Ozkaynak, E et al. (1990) OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J. 9 2085-93 PubMed GONUTS page

[PMID:14679171-19] Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page

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HUMAN:BMP7

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