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PMID:14679171

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Citation

Kalluri, R and Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112:1776-84

Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

Links

PubMed PMC297008 Online version:10.1172/JCI20530

Keywords

Animals; Cytokines/metabolism; Epithelium/physiology; Fibroblasts/metabolism; Fibrosis/pathology; Growth Substances; Humans; Kidney/pathology; Kidney Diseases/pathology; Mesoderm/physiology; Models, Biological; Proteome

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:S10A4

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TGFB2

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CTNB1

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP7

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HGF

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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