HUMAN:HIPK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HIPK2
Protein Name(s)	Homeodomain-interacting protein kinase 2 hHIPk2
External Links
UniProt	Q9H2X6
EMBL	AF208291 AF326592 AC005531 AC073184 AC006021 AC141932 AF207702
CCDS	CCDS75666.1 CCDS75667.1
RefSeq	NP_001106710.1 NP_073577.3
UniGene	Hs.731417
ProteinModelPortal	Q9H2X6
SMR	Q9H2X6
BioGrid	118815
DIP	DIP-31716N
IntAct	Q9H2X6
MINT	MINT-234689
STRING	9606.ENSP00000263551
BindingDB	Q9H2X6
ChEMBL	CHEMBL4576
GuidetoPHARMACOLOGY	2034
PhosphoSite	Q9H2X6
DMDM	21431782
MaxQB	Q9H2X6
PaxDb	Q9H2X6
PRIDE	Q9H2X6
DNASU	28996
Ensembl	ENST00000406875 ENST00000428878
GeneID	28996
KEGG	hsa:28996
UCSC	uc003vvd.4 uc003vvf.4
CTD	28996
GeneCards	GC07M139246
HGNC	HGNC:14402
HPA	HPA007611
MIM	606868
neXtProt	NX_Q9H2X6
PharmGKB	PA29291
eggNOG	COG0515
GeneTree	ENSGT00760000119032
HOGENOM	HOG000231785
HOVERGEN	HBG051908
InParanoid	Q9H2X6
KO	K08826
OMA	YSFPHNS
OrthoDB	EOG7034GK
PhylomeDB	Q9H2X6
TreeFam	TF105417
BRENDA	2.7.11.1
Reactome	REACT_118713
SignaLink	Q9H2X6
ChiTaRS	HIPK2
GeneWiki	HIPK2
GenomeRNAi	28996
NextBio	51926
PMAP-CutDB	Q9H2X6
PRO	PR:Q9H2X6
Proteomes	UP000005640
Bgee	Q9H2X6
CleanEx	HS_HIPK2
ExpressionAtlas	Q9H2X6
Genevestigator	Q9H2X6
GO	GO:0005737 GO:0016604 GO:0005634 GO:0016605 GO:0005524 GO:0004672 GO:0004674 GO:0001102 GO:0001105 GO:0046332 GO:0003714 GO:0046790 GO:0007628 GO:0009952 GO:0071456 GO:0006978 GO:0048596 GO:0060059 GO:0030218 GO:0001654 GO:0097193 GO:0042771 GO:0061072 GO:0060235 GO:0019048 GO:0030514 GO:0043524 GO:0000122 GO:0030182 GO:0018105 GO:0018107 GO:0030578 GO:0045766 GO:0008284 GO:0043388 GO:0046330 GO:0032092 GO:0001934 GO:0051091 GO:0045944 GO:0045893 GO:0030511 GO:0006468 GO:0051726 GO:0010842 GO:0060395 GO:0007224 GO:0007179 GO:0050882
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:20307497^[1]	ECO:0000021		UniProtKB:P35222	F		figure S1	complete
	GO:0045449	regulation of transcription	PMID:20307497^[1]	ECO:0000315			P		figure 2	complete
	GO:0031647	regulation of protein stability	PMID:20307497^[1]	ECO:0000315			P		figure 1D	complete
	GO:0051246	regulation of protein metabolic process	PMID:20307497^[1]	ECO:0000315			P		figure 1E	complete
	GO:0030111	regulation of Wnt receptor signaling pathway	PMID:20307497^[1]	ECO:0000315			P		figure 2A	complete
	GO:0060828	regulation of canonical Wnt receptor signaling pathway	PMID:20307497^[1]	ECO:0000315			P		figure 2	complete
	GO:0016310	phosphorylation	PMID:20307497^[1]	ECO:0000314			P		figure 3B	complete
	GO:0061136	regulation of proteasomal protein catabolic process	PMID:20307497^[1]	ECO:0000315			P		figure 3	complete
	GO:0008283	cell proliferation	PMID:20307497^[1]	ECO:0000315			P		figure 4A,B	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	C		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14647468^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	PMID:14647468^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:14647468^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14647468^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
contributes_to	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:15122315^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:12874272^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046790	virion binding	PMID:14990717^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04487	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12874272^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12874272^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:14678985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:19046997^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:12874272^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:14678985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:20231426^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
involved_in	GO:0019048	modulation by virus of host morphology or physiology	PMID:14990717^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:12874272^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19448668^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12220523^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19448668^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9P1Z0)	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:12874272^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:20579985^[11]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18695000^[12]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16917507^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:21628596^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	C		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0060235	lens induction in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0050882	voluntary musculoskeletal movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0010842	retina layer formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZR5 ensembl:ENSMUSP00000124133	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9748262^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9748262^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:9748262^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:18974774^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:18974774^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:18974774^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030578	PML body organization	PMID:18974774^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:14626429^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9022314 Reactome:R-HSA-8878054 Reactome:R-HSA-8878050 Reactome:R-HSA-6799409 Reactome:R-HSA-4090284 Reactome:R-HSA-3215251	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-6799409	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Möller, A et al. (2003) Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene 22 8731-7 PubMed GONUTS page
↑ Di Stefano, V et al. (2004) HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23 5185-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Harada, J et al. (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J. Biol. Chem. 278 38998-9005 PubMed GONUTS page
↑ ^5.0 ^5.1 Giraud, S et al. (2004) US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J. Virol. 78 2984-93 PubMed GONUTS page
↑ ^6.0 ^6.1 Hofmann, TG et al. (2003) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res. 63 8271-7 PubMed GONUTS page
↑ Nardinocchi, L et al. (2009) Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. Biochim. Biophys. Acta 1793 368-77 PubMed GONUTS page
↑ Hattangadi, SM et al. (2010) Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood 115 4853-61 PubMed GONUTS page
↑ ^9.0 ^9.1 Yamada, D et al. (2009) The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Oncogene 28 2535-44 PubMed GONUTS page
↑ Wang, Y et al. (2002) HIPK2 associates with RanBPM. Biochem. Biophys. Res. Commun. 297 148-53 PubMed GONUTS page
↑ Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page
↑ Wee, HJ et al. (2008) PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112 3777-87 PubMed GONUTS page
↑ Aikawa, Y et al. (2006) Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 25 3955-65 PubMed GONUTS page
↑ Swarup, S & Verheyen, EM (2011) Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc. Natl. Acad. Sci. U.S.A. 108 9887-92 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Sombroek, D & Hofmann, TG (2009) How cells switch HIPK2 on and off. Cell Death Differ. 16 187-94 PubMed GONUTS page
↑ Möller, A & Schmitz, ML (2003) Viruses as hijackers of PML nuclear bodies. Arch. Immunol. Ther. Exp. (Warsz.) 51 295-300 PubMed GONUTS page

[PMID:20307497-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page

[PMID:14647468-2] 2.0 ^2.1 ^2.2 ^2.3 Möller, A et al. (2003) Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene 22 8731-7 PubMed GONUTS page

[PMID:15122315-3] Di Stefano, V et al. (2004) HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23 5185-92 PubMed GONUTS page

[PMID:12874272-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Harada, J et al. (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J. Biol. Chem. 278 38998-9005 PubMed GONUTS page

[PMID:14990717-5] 5.0 ^5.1 Giraud, S et al. (2004) US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J. Virol. 78 2984-93 PubMed GONUTS page

[PMID:14678985-6] 6.0 ^6.1 Hofmann, TG et al. (2003) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res. 63 8271-7 PubMed GONUTS page

[PMID:19046997-7] Nardinocchi, L et al. (2009) Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. Biochim. Biophys. Acta 1793 368-77 PubMed GONUTS page

[PMID:20231426-8] Hattangadi, SM et al. (2010) Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood 115 4853-61 PubMed GONUTS page

[PMID:19448668-9] 9.0 ^9.1 Yamada, D et al. (2009) The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Oncogene 28 2535-44 PubMed GONUTS page

[PMID:12220523-10] Wang, Y et al. (2002) HIPK2 associates with RanBPM. Biochem. Biophys. Res. Commun. 297 148-53 PubMed GONUTS page

[PMID:20579985-11] Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page

[PMID:18695000-12] Wee, HJ et al. (2008) PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112 3777-87 PubMed GONUTS page

[PMID:16917507-13] Aikawa, Y et al. (2006) Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 25 3955-65 PubMed GONUTS page

[PMID:21628596-14] Swarup, S & Verheyen, EM (2011) Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc. Natl. Acad. Sci. U.S.A. 108 9887-92 PubMed GONUTS page

[PMID:9748262-15] 15.0 ^15.1 ^15.2 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page

[PMID:18974774-16] 16.0 ^16.1 ^16.2 ^16.3 Sombroek, D & Hofmann, TG (2009) How cells switch HIPK2 on and off. Cell Death Differ. 16 187-94 PubMed GONUTS page

[PMID:14626429-17] Möller, A & Schmitz, ML (2003) Viruses as hijackers of PML nuclear bodies. Arch. Immunol. Ther. Exp. (Warsz.) 51 295-300 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

HUMAN:HIPK2

Contents

Annotations

Notes

References

a

c

d

e

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools