RAT:GDF8

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Mstn (synonyms: Gdf8)
Protein Name(s)	Growth/differentiation factor 8 GDF-8 Myostatin
External Links
UniProt	O35312
EMBL	AF019624
RefSeq	NP_062024.1
UniGene	Rn.44460
ProteinModelPortal	O35312
STRING	10116.ENSRNOP00000038159
PaxDb	O35312
PRIDE	O35312
Ensembl	ENSRNOT00000038093
GeneID	29152
KEGG	rno:29152
UCSC	RGD:3115
CTD	2660
RGD	3115
eggNOG	NOG310007
GeneTree	ENSGT00760000119112
HOGENOM	HOG000006566
HOVERGEN	HBG000217
InParanoid	O35312
KO	K05497
OMA	NPFLEVR
OrthoDB	EOG74R1Q4
PhylomeDB	O35312
TreeFam	TF318514
NextBio	608163
PRO	PR:O35312
Proteomes	UP000002494
Genevestigator	O35312
GO	GO:0005737 GO:0005615 GO:0008201 GO:0071549 GO:0014741 GO:0048632 GO:0022602 GO:0045893 GO:0051602 GO:0043627 GO:0045471 GO:0051384 GO:0009629 GO:0009408 GO:0014850 GO:0033574 GO:0014732 GO:0043403 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR015616 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848 PTHR11848:SF13
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
involved_in	GO:2000818	negative regulation of myoblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902725	negative regulation of satellite cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	PMID:18787495^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:16919545^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:16575154^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:14749210^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:18845635^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	PMID:11206133^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	PMID:18841527^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0022602	ovulation cycle process	PMID:18845635^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	PMID:15743390^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014741	negative regulation of muscle hypertrophy	PMID:16810717^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	PMID:15758361^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	PMID:11115768^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:11481237^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17679144^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16575154^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015616	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR015616 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lima, SC et al. (2009) Muscle and nerve responses after different intervals of electrical stimulation sessions on denervated rat muscle. Am J Phys Med Rehabil 88 126-35 PubMed GONUTS page
↑ Salehian, B et al. (2006) The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Metab. Clin. Exp. 55 1239-47 PubMed GONUTS page
↑ ^3.0 ^3.1 Hosoyama, T et al. (2006) Role of serum myostatin during the lactation period. J. Reprod. Dev. 52 469-78 PubMed GONUTS page
↑ Lang, CH et al. (2004) IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am. J. Physiol. Endocrinol. Metab. 286 E916-26 PubMed GONUTS page
↑ ^5.0 ^5.1 Ciarmela, P et al. (2009) Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology 150 906-14 PubMed GONUTS page
↑ Mendler, L et al. (2000) Myostatin levels in regenerating rat muscles and in myogenic cell cultures. J. Muscle Res. Cell. Motil. 21 551-63 PubMed GONUTS page
↑ Rigamonti, AE et al. (2009) Muscle expressions of MGF, IGF-IEa, and myostatin in intact and hypophysectomized rats: effects of rhGH and testosterone alone or combined. Horm. Metab. Res. 41 23-9 PubMed GONUTS page
↑ Matsakas, A et al. (2005) Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Acta Physiol. Scand. 183 299-307 PubMed GONUTS page
↑ Magee, TR et al. (2006) Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med 8 1171-81 PubMed GONUTS page
↑ Baumann, AP et al. (2003) Myostatin expression in age and denervation-induced skeletal muscle atrophy. J Musculoskelet Neuronal Interact 3 8-16 PubMed GONUTS page
↑ Lalani, R et al. (2000) Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J. Endocrinol. 167 417-28 PubMed GONUTS page
↑ Lang, CH et al. (2001) Regulation of myostatin by glucocorticoids after thermal injury. FASEB J. 15 1807-9 PubMed GONUTS page
↑ Nishimura, T et al. (2007) Spatiotemporal expression of decorin and myostatin during rat skeletal muscle development. Biochem. Biophys. Res. Commun. 361 896-902 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18787495-1] Lima, SC et al. (2009) Muscle and nerve responses after different intervals of electrical stimulation sessions on denervated rat muscle. Am J Phys Med Rehabil 88 126-35 PubMed GONUTS page

[PMID:16919545-2] Salehian, B et al. (2006) The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Metab. Clin. Exp. 55 1239-47 PubMed GONUTS page

[PMID:16575154-3] 3.0 ^3.1 Hosoyama, T et al. (2006) Role of serum myostatin during the lactation period. J. Reprod. Dev. 52 469-78 PubMed GONUTS page

[PMID:14749210-4] Lang, CH et al. (2004) IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am. J. Physiol. Endocrinol. Metab. 286 E916-26 PubMed GONUTS page

[PMID:18845635-5] 5.0 ^5.1 Ciarmela, P et al. (2009) Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology 150 906-14 PubMed GONUTS page

[PMID:11206133-6] Mendler, L et al. (2000) Myostatin levels in regenerating rat muscles and in myogenic cell cultures. J. Muscle Res. Cell. Motil. 21 551-63 PubMed GONUTS page

[PMID:18841527-7] Rigamonti, AE et al. (2009) Muscle expressions of MGF, IGF-IEa, and myostatin in intact and hypophysectomized rats: effects of rhGH and testosterone alone or combined. Horm. Metab. Res. 41 23-9 PubMed GONUTS page

[PMID:15743390-8] Matsakas, A et al. (2005) Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Acta Physiol. Scand. 183 299-307 PubMed GONUTS page

[PMID:16810717-9] Magee, TR et al. (2006) Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med 8 1171-81 PubMed GONUTS page

[PMID:15758361-10] Baumann, AP et al. (2003) Myostatin expression in age and denervation-induced skeletal muscle atrophy. J Musculoskelet Neuronal Interact 3 8-16 PubMed GONUTS page

[PMID:11115768-11] Lalani, R et al. (2000) Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J. Endocrinol. 167 417-28 PubMed GONUTS page

[PMID:11481237-12] Lang, CH et al. (2001) Regulation of myostatin by glucocorticoids after thermal injury. FASEB J. 15 1807-9 PubMed GONUTS page

[PMID:17679144-13] Nishimura, T et al. (2007) Spatiotemporal expression of decorin and myostatin during rat skeletal muscle development. Biochem. Biophys. Res. Commun. 361 896-902 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:GDF8

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References

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