MOUSE:GATA4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gata4 (synonyms: Gata-4)
Protein Name(s)	Transcription factor GATA-4 GATA-binding factor 4
External Links
UniProt	Q08369
EMBL	M98339 U85046 AF179424 AC090654 AC090962 CH466535 BC137824
CCDS	CCDS49519.1
PIR	A48099
RefSeq	NP_032118.2
UniGene	Mm.247669
ProteinModelPortal	Q08369
SMR	Q08369
BioGrid	199841
DIP	DIP-33032N
IntAct	Q08369
MINT	MINT-206005
ChEMBL	CHEMBL1687680
PhosphoSite	Q08369
PaxDb	Q08369
PRIDE	Q08369
Ensembl	ENSMUST00000118022
GeneID	14463
KEGG	mmu:14463
UCSC	uc007uhn.1
CTD	2626
MGI	MGI:95664
eggNOG	COG5641
GeneTree	ENSGT00760000119221
HOVERGEN	HBG051703
InParanoid	Q08369
KO	K09183
PhylomeDB	Q08369
Reactome	REACT_196516 REACT_198649 REACT_253751
NextBio	286104
PRO	PR:Q08369
Proteomes	UP000000589
CleanEx	MM_GATA4
ExpressionAtlas	Q08369
Genevestigator	Q08369
GO	GO:0000790 GO:0005634 GO:0003682 GO:0003677 GO:0000978 GO:0003705 GO:0000977 GO:0001076 GO:0043565 GO:0000981 GO:0003700 GO:0044212 GO:0008270 GO:0003289 GO:0036302 GO:0003190 GO:0003181 GO:0030509 GO:0060070 GO:0055007 GO:0014898 GO:0048738 GO:0003215 GO:0003279 GO:0007267 GO:0071372 GO:0071371 GO:0060540 GO:0048557 GO:0048617 GO:0035054 GO:0035050 GO:0048598 GO:0003197 GO:0001706 GO:0072148 GO:0001702 GO:0007507 GO:0001947 GO:0003007 GO:0001701 GO:0060575 GO:0060464 GO:0060425 GO:0003192 GO:0003151 GO:0045766 GO:0060045 GO:0051891 GO:0045944 GO:0045893 GO:0010575 GO:0060043 GO:0010468 GO:0006357 GO:0006355 GO:0043627 GO:0032526 GO:0072520 GO:0060008 GO:0023019 GO:0035914 GO:0060395 GO:0007283 GO:0006366 GO:0003195 GO:0035239 GO:0060979 GO:0003229 GO:0003281
Gene3D	3.30.50.10
InterPro	IPR008013 IPR028436 IPR016375 IPR000679 IPR013088
PANTHER	PTHR10071:SF154
Pfam	PF00320 PF05349
PIRSF	PIRSF003028
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:23558708^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000070348)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23558708^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:23558708^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000006FDD4_10090) occurs_in:(UBERON:0002371) occurs_in:(CL:0000134)\|occurs_in:(CL:0000746) part_of:(GO:0071456) has_regulation_target:(RNAcentral:URS000006FDD4_10090)\|occurs_in(UBERON:0002349) part_of:(GO:0071456) has_regulation_target:(RNAcentral:URS000006FDD4_10090)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) part_of:(GO:0051896)	Seeded From UniProt	complete
involved_in	GO:0051896	regulation of protein kinase B signaling	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) has_agent:(GO:0070062) regulates_expression_of:(ENSEMBL:ENSMUSG00000027381)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) regulates_expression_of:(ENSEMBL:ENSMUSG00000013663)	Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	PMID:25590961^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000006FDD4_10090	P		Seeded From UniProt	complete
involved_in	GO:1905204	negative regulation of connective tissue replacement	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:2000046) part_of:(GO:0002931) part_of:(GO:0061042)	Seeded From UniProt	complete
involved_in	GO:0061026	cardiac muscle tissue regeneration	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0002931)	Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:25590961^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	PMID:16137232^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051891	positive regulation of cardioblast differentiation	PMID:16137232^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21220346^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16137232^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21029371^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17975667^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:17975667^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:21330551^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:18439490^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:17975667^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12845333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21220346^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17975667^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17975667^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	PMID:17643447^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	PMID:17643447^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003279	cardiac septum development	PMID:21330551^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	PMID:17643447^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	PMID:17643447^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003190	atrioventricular valve formation	PMID:21330551^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97471	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:17975667^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:15310850^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21029371^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21029371^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21029371^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	PMID:21556048^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12845333^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035914	skeletal muscle cell differentiation	PMID:21556048^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:12845333^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95664 PANTHER:PTN002560190 RGD:2665 ZFIN:ZDB-GENE-980526-476	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	PMID:9231805^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8754853^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8455608^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035239	tube morphogenesis	PMID:18400219^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107516	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035054	embryonic heart tube anterior/posterior pattern specification	PMID:9136932^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386265	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035050	embryonic heart tube development	PMID:9136933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179443	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035050	embryonic heart tube development	PMID:9136932^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386265	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:17360443^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014898	cardiac muscle hypertrophy in response to stress	PMID:20705924^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3054171,MGI:MGI:3778685	P	has_participant:(EMAPA:32688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:18400219^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107516	P	occurs_in:(CL:0002322) has_regulation_target:(MGI:MGI:97350)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:1888496)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:102541)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:99458)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:109497)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:103577)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:103580)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:107785)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:1096325)\|occurs_in(CL:0002322) has_regulation_target:(MGI:MGI:101791)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:20833366^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009612	response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15464586^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526853 MGI:MGI:3526854 MGI:MGI:3526856	P	results_in_development_of:(EMAPA:16688)\|results_in_development_of:(EMAPA:17872)\|results_in_development_of:(EMAPA:17339)\|results_in_development_of:(EMAPA:17342)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:11297508^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386764	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:21172404^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3042214,MGI:MGI:3778685	P	occurs_in:(EMAPA:25765)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:16127717^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386764	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:8455608^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:8007990^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15082719^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:14978031^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:12606418^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:9738004^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24268575^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21146513^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20123909^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17548362^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16940177^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000677)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12801993^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35627) part_of:(CL:0000501)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9566909^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694 UniProtKB:Q91677	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9738004^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15082719^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21379568^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9738004^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8007990^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15539431^[41]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95674)\|has_participant:(MGI:MGI:95674)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46152	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003290	atrial septum secundum morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003229	ventricular cardiac muscle tissue development	PMID:19084512^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003197	endocardial cushion development	PMID:19084512^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003197	endocardial cushion development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003181	atrioventricular valve morphogenesis	PMID:19084512^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003180	aortic valve morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001706	endoderm formation	PMID:8582296^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:9136933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179443	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9136933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179443	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9136932^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386265	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:20123909^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3793424	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:15310850^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3033220	P	has_participant:(EMAPA:16131)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21379568^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17548362^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:16603706^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:16603706^[44]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086004	regulation of cardiac muscle cell contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072520	seminiferous tubule development	PMID:21172404^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3042214,MGI:MGI:3778685	P	results_in_development_of:(EMAPA:25765)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072148	epithelial cell fate commitment	PMID:16940177^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3053826,MGI:MGI:3526854	P	occurs_in:(EMAPA:18666) results_in_commitment_to:(CL:0000160)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071372	cellular response to follicle-stimulating hormone stimulus	PMID:9231805^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071371	cellular response to gonadotropin stimulus	PMID:9231805^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061049	cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060575	intestinal epithelial cell differentiation	PMID:9566909^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060464	lung lobe formation	PMID:17142311^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386764	P	results_in_formation_of:(EMAPA:17981)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060413	atrial septum morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	PMID:9420335^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060290	transdifferentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:17360443^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:19084512^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060043	regulation of cardiac muscle cell proliferation	PMID:15902305^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526854	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060008	Sertoli cell differentiation	PMID:21172404^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3042214,MGI:MGI:3778685	P	occurs_in:(EMAPA:25765)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:20691899^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541 MGI:MGI:99458	P	results_in_acquisition_of_features_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:18400219^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:18400219^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3793424	P		Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048738	cardiac muscle tissue development	PMID:20705924^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107516	P	results_in_development_of:(EMAPA:32688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:9136933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179443	P	has_participant:(EMAPA:16247)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:9136932^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386265	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048598	embryonic morphogenesis	PMID:9136933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179443	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048598	embryonic morphogenesis	PMID:9136932^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386265	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:16127717^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386764	P	has_participant:(EMAPA:17023)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15766748^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1334444 MGI:MGI:98214	P	has_regulation_target:(MGI:MGI:95407)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15539431^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472 MGI:MGI:1347476	P	has_regulation_target:(MGI:MGI:95674)\|has_regulation_target:(MGI:MGI:95674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17272516^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526856	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8455608^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8007990^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17548362^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16380715^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15539431^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95674)\|has_regulation_target:(MGI:MGI:95674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9566909^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q91677	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14978031^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9566909^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694 UniProtKB:Q91677	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2665	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR016375	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR008013 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	P		Seeded From UniProt	complete
involved_in	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	PMID:20299672^[52]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:20299672^[52]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060540	diaphragm morphogenesis	PMID:17643447^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	PMID:17643447^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003195	tricuspid valve formation	PMID:14614148^[53]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003192	mitral valve formation	PMID:14614148^[53]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	PMID:14614148^[53]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:14614148^[53]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yao, CX et al. (2013) miR-200b targets GATA-4 during cell growth and differentiation. RNA Biol 10 465-80 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Yu, B et al. (2015) Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int. J. Cardiol. 182 349-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Brewer, AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev. 14 425-39 PubMed GONUTS page
↑ ^4.0 ^4.1 Lourenço, D et al. (2011) Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Proc. Natl. Acad. Sci. U.S.A. 108 1597-602 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Salisch, Sv et al. (2011) Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. J. Cell. Mol. Med. 15 1963-72 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Heineke, J et al. (2007) Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J. Clin. Invest. 117 3198-210 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Moskowitz, IP et al. (2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc. Natl. Acad. Sci. U.S.A. 108 4006-11 PubMed GONUTS page
↑ Su, D & Gudas, LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp. Hematol. 36 624-41 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Garg, V et al. (2003) GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424 443-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Rajagopal, SK et al. (2007) Spectrum of heart disease associated with murine and human GATA4 mutation. J. Mol. Cell. Cardiol. 43 677-85 PubMed GONUTS page
↑ ^11.0 ^11.1 Watt, AJ et al. (2004) GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc. Natl. Acad. Sci. U.S.A. 101 12573-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Al Madhoun, AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 30 2477-89 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Heikinheimo, M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138 3505-14 PubMed GONUTS page
↑ McGrew, MJ et al. (1996) Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus. Mol. Cell. Biol. 16 4524-34 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Arceci, RJ et al. (1993) Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13 2235-46 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Zhao, R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev. Biol. 317 614-9 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Kuo, CT et al. (1997) GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11 1048-60 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Molkentin, JD et al. (1997) Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11 1061-72 PubMed GONUTS page
↑ ^20.0 ^20.1 Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page
↑ Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page
↑ ^22.0 ^22.1 van Berlo, JH et al. (2010) The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ. Res. 107 1032-40 PubMed GONUTS page
↑ Trivedi, CM et al. (2010) Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev. Cell 19 450-9 PubMed GONUTS page
↑ Pu, WT et al. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev. Biol. 275 235-44 PubMed GONUTS page
↑ Crispino, JD et al. (2001) Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15 839-44 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Kyrönlahti, A et al. (2011) GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol. Cell. Endocrinol. 333 85-95 PubMed GONUTS page
↑ ^27.0 ^27.1 Jacobsen, CM et al. (2005) GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev. Dyn. 234 355-62 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Molkentin, JD et al. (1994) Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol. Cell. Biol. 14 4947-57 PubMed GONUTS page
↑ ^29.0 ^29.1 Murakami, A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279 28564-73 PubMed GONUTS page
↑ ^30.0 ^30.1 Plageman, TF Jr & Yutzey, KE (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J. Biol. Chem. 279 19026-34 PubMed GONUTS page
↑ Anttonen, M et al. (2003) FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol. Reprod. 68 1333-40 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Di Lisi, R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J. Biol. Chem. 273 25371-80 PubMed GONUTS page
↑ Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page
↑ Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page
↑ ^35.0 ^35.1 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Philips, AS et al. (2007) Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J. Biol. Chem. 282 24915-27 PubMed GONUTS page
↑ ^37.0 ^37.1 Bosse, T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol. Cell. Biol. 26 9060-70 PubMed GONUTS page
↑ Balla, A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol. Reprod. 69 1281-93 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 Gao, X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18 2901-11 PubMed GONUTS page
↑ ^40.0 ^40.1 Schlesinger, J et al. (2011) The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet. 7 e1001313 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 Ritz-Laser, B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol. Endocrinol. 19 759-70 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 Maitra, M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev. Biol. 326 368-77 PubMed GONUTS page
↑ Soudais, C et al. (1995) Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121 3877-88 PubMed GONUTS page
↑ ^44.0 ^44.1 Xiang, F et al. (2006) Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am. J. Physiol. Heart Circ. Physiol. 290 H1997-2006 PubMed GONUTS page
↑ Ackerman, KG et al. (2007) Gata4 is necessary for normal pulmonary lobar development. Am. J. Respir. Cell Mol. Biol. 36 391-7 PubMed GONUTS page
↑ Sirard, C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12 107-19 PubMed GONUTS page
↑ Zeisberg, EM et al. (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J. Clin. Invest. 115 1522-31 PubMed GONUTS page
↑ Ieda, M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142 375-86 PubMed GONUTS page
↑ Makita, T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev. Biol. 280 59-72 PubMed GONUTS page
↑ Bosse, T et al. (2007) Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G1302-14 PubMed GONUTS page
↑ Koshiba-Takeuchi, K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat. Genet. 38 175-83 PubMed GONUTS page
↑ ^52.0 ^52.1 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 ^53.3 Katz, SG et al. (2003) Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc. Natl. Acad. Sci. U.S.A. 100 14030-5 PubMed GONUTS page

[PMID:23558708-1] 1.0 ^1.1 ^1.2 Yao, CX et al. (2013) miR-200b targets GATA-4 during cell growth and differentiation. RNA Biol 10 465-80 PubMed GONUTS page

[PMID:25590961-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Yu, B et al. (2015) Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int. J. Cardiol. 182 349-60 PubMed GONUTS page

[PMID:16137232-3] 3.0 ^3.1 ^3.2 Brewer, AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev. 14 425-39 PubMed GONUTS page

[PMID:21220346-4] 4.0 ^4.1 Lourenço, D et al. (2011) Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Proc. Natl. Acad. Sci. U.S.A. 108 1597-602 PubMed GONUTS page

[PMID:21029371-5] 5.0 ^5.1 ^5.2 ^5.3 Salisch, Sv et al. (2011) Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. J. Cell. Mol. Med. 15 1963-72 PubMed GONUTS page

[PMID:17975667-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Heineke, J et al. (2007) Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J. Clin. Invest. 117 3198-210 PubMed GONUTS page

[PMID:21330551-7] 7.0 ^7.1 ^7.2 Moskowitz, IP et al. (2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc. Natl. Acad. Sci. U.S.A. 108 4006-11 PubMed GONUTS page

[PMID:18439490-8] Su, D & Gudas, LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp. Hematol. 36 624-41 PubMed GONUTS page

[PMID:12845333-9] 9.0 ^9.1 ^9.2 Garg, V et al. (2003) GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424 443-7 PubMed GONUTS page

[PMID:17643447-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Rajagopal, SK et al. (2007) Spectrum of heart disease associated with murine and human GATA4 mutation. J. Mol. Cell. Cardiol. 43 677-85 PubMed GONUTS page

[PMID:15310850-11] 11.0 ^11.1 Watt, AJ et al. (2004) GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc. Natl. Acad. Sci. U.S.A. 101 12573-8 PubMed GONUTS page

[PMID:21556048-12] 12.0 ^12.1 Al Madhoun, AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 30 2477-89 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9231805-14] 14.0 ^14.1 ^14.2 Heikinheimo, M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138 3505-14 PubMed GONUTS page

[PMID:8754853-15] McGrew, MJ et al. (1996) Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus. Mol. Cell. Biol. 16 4524-34 PubMed GONUTS page

[PMID:8455608-16] 16.0 ^16.1 ^16.2 Arceci, RJ et al. (1993) Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13 2235-46 PubMed GONUTS page

[PMID:18400219-17] 17.0 ^17.1 ^17.2 ^17.3 Zhao, R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev. Biol. 317 614-9 PubMed GONUTS page

[PMID:9136932-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Kuo, CT et al. (1997) GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11 1048-60 PubMed GONUTS page

[PMID:9136933-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Molkentin, JD et al. (1997) Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11 1061-72 PubMed GONUTS page

[PMID:17360443-20] 20.0 ^20.1 Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page

[PMID:18462699-21] Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page

[PMID:20705924-22] 22.0 ^22.1 van Berlo, JH et al. (2010) The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ. Res. 107 1032-40 PubMed GONUTS page

[PMID:20833366-23] Trivedi, CM et al. (2010) Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev. Cell 19 450-9 PubMed GONUTS page

[PMID:15464586-24] Pu, WT et al. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev. Biol. 275 235-44 PubMed GONUTS page

[PMID:11297508-25] Crispino, JD et al. (2001) Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15 839-44 PubMed GONUTS page

[PMID:21172404-26] 26.0 ^26.1 ^26.2 Kyrönlahti, A et al. (2011) GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol. Cell. Endocrinol. 333 85-95 PubMed GONUTS page

[PMID:16127717-27] 27.0 ^27.1 Jacobsen, CM et al. (2005) GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev. Dyn. 234 355-62 PubMed GONUTS page

[PMID:8007990-28] 28.0 ^28.1 ^28.2 Molkentin, JD et al. (1994) Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol. Cell. Biol. 14 4947-57 PubMed GONUTS page

[PMID:15082719-29] 29.0 ^29.1 Murakami, A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279 28564-73 PubMed GONUTS page

[PMID:14978031-30] 30.0 ^30.1 Plageman, TF Jr & Yutzey, KE (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J. Biol. Chem. 279 19026-34 PubMed GONUTS page

[PMID:12606418-31] Anttonen, M et al. (2003) FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol. Reprod. 68 1333-40 PubMed GONUTS page

[PMID:9738004-32] 32.0 ^32.1 ^32.2 Di Lisi, R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J. Biol. Chem. 273 25371-80 PubMed GONUTS page

[PMID:24268575-33] Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page

[PMID:21146513-34] Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page

[PMID:20123909-35] 35.0 ^35.1 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page

[PMID:17548362-36] 36.0 ^36.1 ^36.2 Philips, AS et al. (2007) Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J. Biol. Chem. 282 24915-27 PubMed GONUTS page

[PMID:16940177-37] 37.0 ^37.1 Bosse, T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol. Cell. Biol. 26 9060-70 PubMed GONUTS page

[PMID:12801993-38] Balla, A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol. Reprod. 69 1281-93 PubMed GONUTS page

[PMID:9566909-39] 39.0 ^39.1 ^39.2 ^39.3 Gao, X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18 2901-11 PubMed GONUTS page

[PMID:21379568-40] 40.0 ^40.1 Schlesinger, J et al. (2011) The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet. 7 e1001313 PubMed GONUTS page

[PMID:15539431-41] 41.0 ^41.1 ^41.2 Ritz-Laser, B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol. Endocrinol. 19 759-70 PubMed GONUTS page

[PMID:19084512-42] 42.0 ^42.1 ^42.2 ^42.3 Maitra, M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev. Biol. 326 368-77 PubMed GONUTS page

[PMID:8582296-43] Soudais, C et al. (1995) Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121 3877-88 PubMed GONUTS page

[PMID:16603706-44] 44.0 ^44.1 Xiang, F et al. (2006) Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am. J. Physiol. Heart Circ. Physiol. 290 H1997-2006 PubMed GONUTS page

[PMID:17142311-45] Ackerman, KG et al. (2007) Gata4 is necessary for normal pulmonary lobar development. Am. J. Respir. Cell Mol. Biol. 36 391-7 PubMed GONUTS page

[PMID:9420335-46] Sirard, C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12 107-19 PubMed GONUTS page

[PMID:15902305-47] Zeisberg, EM et al. (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J. Clin. Invest. 115 1522-31 PubMed GONUTS page

[PMID:20691899-48] Ieda, M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142 375-86 PubMed GONUTS page

[PMID:15766748-49] Makita, T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev. Biol. 280 59-72 PubMed GONUTS page

[PMID:17272516-50] Bosse, T et al. (2007) Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G1302-14 PubMed GONUTS page

[PMID:16380715-51] Koshiba-Takeuchi, K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat. Genet. 38 175-83 PubMed GONUTS page

[PMID:20299672-52] 52.0 ^52.1 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:14614148-53] 53.0 ^53.1 ^53.2 ^53.3 Katz, SG et al. (2003) Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc. Natl. Acad. Sci. U.S.A. 100 14030-5 PubMed GONUTS page

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[24]

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[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

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[50]

[51]

[52]

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MOUSE:GATA4

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