RAT:SMAD3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Smad3 (synonyms: Madh3)
Protein Name(s)	Mothers against decapentaplegic homolog 3 MAD homolog 3 Mad3 Mothers against DPP homolog 3 SMAD family member 3 SMAD 3 Smad3
External Links
UniProt	P84025
EMBL	U66479 BC064437
RefSeq	NP_037227.1
UniGene	Rn.10636
ProteinModelPortal	P84025
SMR	P84025
BioGrid	247660
IntAct	P84025
MINT	MINT-2739536
STRING	10116.ENSRNOP00000037346
BindingDB	P84025
PhosphoSite	P84025
PaxDb	P84025
PRIDE	P84025
Ensembl	ENSRNOT00000039730
GeneID	25631
KEGG	rno:25631
UCSC	RGD:3032
CTD	4088
RGD	3032
eggNOG	KOG3701 ENOG410XQKU
GeneTree	ENSGT00760000119091
HOVERGEN	HBG053353
InParanoid	P84025
KO	K04500
OMA	AVELCEY
OrthoDB	EOG7W1540
PhylomeDB	P84025
TreeFam	TF314923
Reactome	R-RNO-1181150 R-RNO-1502540 R-RNO-2173788 R-RNO-2173789 R-RNO-2173795 R-RNO-2173796
NextBio	607435
PRO	PR:P84025
Proteomes	UP000002494
Genevisible	P84025
GO	GO:0005737 GO:0000790 GO:0005637 GO:0005634 GO:0005886 GO:0043234 GO:0043235 GO:0071141 GO:0071144 GO:0005667 GO:0031490 GO:0000987 GO:0003677 GO:0019899 GO:0000978 GO:0043565 GO:0046332 GO:0000988 GO:0000983 GO:0003700 GO:0008134 GO:0030618 GO:0008270 GO:0097296 GO:0007050 GO:0045216 GO:0048589 GO:0048701 GO:0048617 GO:0009880 GO:0007492 GO:0019049 GO:0097191 GO:0001947 GO:0006955 GO:0002520 GO:0001701 GO:0070306 GO:0001889 GO:0001707 GO:0043066 GO:0030308 GO:0008285 GO:0050728 GO:0045930 GO:0045668 GO:0033689 GO:0042177 GO:0001933 GO:0000122 GO:0061045 GO:0038092 GO:0002076 GO:0048340 GO:0060039 GO:0010694 GO:0030501 GO:0090263 GO:0035413 GO:0030335 GO:0032332 GO:0010718 GO:1901203 GO:0051894 GO:0032731 GO:0050927 GO:0051496 GO:0042993 GO:0045944 GO:0032916 GO:0050821 GO:0051098 GO:0050678 GO:0050776 GO:0016202 GO:0017015 GO:0032909 GO:0001666 GO:0023019 GO:0007183 GO:0060395 GO:0001756 GO:0042110 GO:0030878 GO:0006351 GO:0060290 GO:0007179 GO:0006810 GO:0001657
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:16690606^[1]	ECO:0000314			C		Figure 3 shows accumulation of SMAD3 in the nucleus	complete CACAO 11817
	GO:0042177	negative regulation of protein catabolic process	PMID:16690606^[1]	ECO:0000314			P		Figure 4	complete CACAO 11820
	GO:0005634	nucleus	PMID:20097766^[2]	ECO:0000314			C		Figure 4C shows localization of wild type SMAD3 in the nucleus	complete CACAO 11863
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:27038547^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10116	P	occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	PMID:27038547^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10116	P	occurs_in:(UBERON:0002080)	Seeded From UniProt	complete
involved_in	GO:0061767	negative regulation of lung blood pressure	PMID:27038547^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10116	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22073128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:22073128^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	PMID:22073128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P02454) happens_during:(GO:0007179)\|has_regulation_target(UniProtKB:P13941) happens_during:(GO:0007179)\|has_regulation_target(UniProtKB:P30120) happens_during:(GO:0007179)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:22073128^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27008	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:22073128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22073128^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:20097766^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	PMID:20097766^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20097766^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:20097766^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
involved_in	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:11839804^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060290	transdifferentiation	PMID:15987742^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:15987742^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:15987742^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	PMID:15987742^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:16959941^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3033	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16891311^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12702545^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16891311^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16205635^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12702545^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:14517210^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16959941^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032916	positive regulation of transforming growth factor beta3 production	PMID:16891311^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:16371439^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:12096832^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17545585^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	PMID:12844345^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:22073128^[4]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2053	F		Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	PMID:12096832^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:15987742^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18486259^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16858008^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	PMID:16959941^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2401 RGD:3033	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:16891311^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:16371439^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17545585^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:16891311^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17545585^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16959941^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12702545^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16959941^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16205635^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:1901203	positive regulation of extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
part_of	GO:0071144	heteromeric SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0038092	nodal signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20097766^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 4. details explained by the "Smad3 Promotes β-Catenin Nuclear Translocation" section of the paper	complete CACAO 11687
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:16690606^[1]	ECO:0000314			C		Figure 3 shows accumulation of SMAD3 in the nucleus	complete CACAO 11697
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
	GO:0042177	negative regulation of protein catabolic process	PMID:16690606^[1]	ECO:0000314			P		Figure 4	complete CACAO 11760
enables	GO:0031962	mineralocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0019049	evasion or tolerance of host defenses by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0060039	pericardium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0051098	regulation of binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0048617	embryonic foregut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0048340	paraxial mesoderm morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0033689	negative regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0016202	regulation of striated muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0002520	immune system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BUN5 ensembl:ENSMUSP00000034973	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z3 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z3 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Li, TF et al. (2006) Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J. Biol. Chem. 281 21296-304 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Liu, Y et al. (2016) MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3. Biochem. Biophys. Res. Commun. 473 859-866 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Huang, D et al. (2011) Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell. PLoS ONE 6 e27123 PubMed GONUTS page
↑ Kim, BC et al. (2002) Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Mol. Cell. Biol. 22 1369-78 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Uemura, M et al. (2005) Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol. Biol. Cell 16 4214-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Liu, X et al. (2006) cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Mol. Pharmacol. 70 1992-2003 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Liu, G et al. (2006) Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. J. Biol. Chem. 281 29479-90 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Hu, B et al. (2003) Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am. J. Respir. Cell Mol. Biol. 29 397-404 PubMed GONUTS page
↑ ^10.0 ^10.1 Hu, B et al. (2006) Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Oncogene 25 1030-41 PubMed GONUTS page
↑ Sowa, H et al. (2003) Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. J. Biol. Chem. 278 52240-52 PubMed GONUTS page
↑ ^12.0 ^12.1 Aoki, H et al. (2006) Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am. J. Physiol., Cell Physiol. 290 C1100-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Sowa, H et al. (2002) Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J. Bone Miner. Res. 17 1190-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Sekimoto, G et al. (2007) Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Cancer Res. 67 5090-6 PubMed GONUTS page
↑ Wang, EY et al. (2003) Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. J. Endocrinol. 178 137-48 PubMed GONUTS page
↑ Gressner, OA et al. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49 758-67 PubMed GONUTS page
↑ Hu, B et al. (2007) Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Am. J. Respir. Cell Mol. Biol. 36 78-84 PubMed GONUTS page

[PMID:16690606-1] 1.0 ^1.1 ^1.2 ^1.3 Li, TF et al. (2006) Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J. Biol. Chem. 281 21296-304 PubMed GONUTS page

[PMID:20097766-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page

[PMID:27038547-3] 3.0 ^3.1 ^3.2 Liu, Y et al. (2016) MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3. Biochem. Biophys. Res. Commun. 473 859-866 PubMed GONUTS page

[PMID:22073128-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Huang, D et al. (2011) Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell. PLoS ONE 6 e27123 PubMed GONUTS page

[PMID:11839804-5] Kim, BC et al. (2002) Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Mol. Cell. Biol. 22 1369-78 PubMed GONUTS page

[PMID:15987742-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Uemura, M et al. (2005) Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol. Biol. Cell 16 4214-24 PubMed GONUTS page

[PMID:16959941-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Liu, X et al. (2006) cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Mol. Pharmacol. 70 1992-2003 PubMed GONUTS page

[PMID:16891311-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Liu, G et al. (2006) Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. J. Biol. Chem. 281 29479-90 PubMed GONUTS page

[PMID:12702545-9] 9.0 ^9.1 ^9.2 Hu, B et al. (2003) Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am. J. Respir. Cell Mol. Biol. 29 397-404 PubMed GONUTS page

[PMID:16205635-10] 10.0 ^10.1 Hu, B et al. (2006) Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Oncogene 25 1030-41 PubMed GONUTS page

[PMID:14517210-11] Sowa, H et al. (2003) Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. J. Biol. Chem. 278 52240-52 PubMed GONUTS page

[PMID:16371439-12] 12.0 ^12.1 Aoki, H et al. (2006) Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am. J. Physiol., Cell Physiol. 290 C1100-8 PubMed GONUTS page

[PMID:12096832-13] 13.0 ^13.1 Sowa, H et al. (2002) Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J. Bone Miner. Res. 17 1190-9 PubMed GONUTS page

[PMID:17545585-14] 14.0 ^14.1 ^14.2 Sekimoto, G et al. (2007) Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Cancer Res. 67 5090-6 PubMed GONUTS page

[PMID:12844345-15] Wang, EY et al. (2003) Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. J. Endocrinol. 178 137-48 PubMed GONUTS page

[PMID:18486259-16] Gressner, OA et al. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49 758-67 PubMed GONUTS page

[PMID:16858008-17] Hu, B et al. (2007) Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Am. J. Respir. Cell Mol. Biol. 36 78-84 PubMed GONUTS page

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RAT:SMAD3

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