MOUSE:SMAD3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad3 (synonyms: Madh3)
Protein Name(s)	Mothers against decapentaplegic homolog 3 MAD homolog 3 Mad3 Mothers against DPP homolog 3 mMad3 SMAD family member 3 SMAD 3 Smad3
External Links
UniProt	Q8BUN5
EMBL	AB008192 AF016189 AK048626 AK083158 BC066850
CCDS	CCDS23272.1
RefSeq	NP_058049.3
UniGene	Mm.7320
ProteinModelPortal	Q8BUN5
SMR	Q8BUN5
BioGrid	201276
DIP	DIP-29717N
IntAct	Q8BUN5
MINT	MINT-262056
BindingDB	Q8BUN5
PhosphoSite	Q8BUN5
MaxQB	Q8BUN5
PaxDb	Q8BUN5
PRIDE	Q8BUN5
Ensembl	ENSMUST00000034973
GeneID	17127
KEGG	mmu:17127
UCSC	uc009qbi.1
CTD	4088
MGI	MGI:1201674
eggNOG	NOG320700
GeneTree	ENSGT00760000119091
HOVERGEN	HBG053353
InParanoid	Q8BUN5
KO	K04500
OMA	AVELCEY
OrthoDB	EOG7W1540
PhylomeDB	Q8BUN5
TreeFam	TF314923
Reactome	REACT_202264 REACT_203510 REACT_203903 REACT_215733 REACT_216258 REACT_216792 REACT_217958 REACT_220566 REACT_220645 REACT_224802
NextBio	16026
PRO	PR:Q8BUN5
Proteomes	UP000000589
Bgee	Q8BUN5
CleanEx	MM_SMAD3
ExpressionAtlas	Q8BUN5
Genevestigator	Q8BUN5
GO	GO:0005737 GO:0000790 GO:0005637 GO:0005634 GO:0005886 GO:0043235 GO:0071141 GO:0071144 GO:0005667 GO:0003682 GO:0031490 GO:0005518 GO:0000987 GO:0003690 GO:0000988 GO:0046982 GO:0042803 GO:0003700 GO:0008134 GO:0030618 GO:0008270 GO:0097296 GO:0007050 GO:0045216 GO:0048589 GO:0048701 GO:0048617 GO:0009880 GO:0007492 GO:0019049 GO:0097191 GO:0007369 GO:0001947 GO:0006955 GO:0002520 GO:0001701 GO:0070306 GO:0001889 GO:0001707 GO:0043066 GO:0030308 GO:0050728 GO:0045930 GO:0045668 GO:0033689 GO:0042177 GO:0001933 GO:0000122 GO:0061045 GO:0038092 GO:0002076 GO:0001649 GO:0048340 GO:0060039 GO:0010694 GO:0030501 GO:0090263 GO:0035413 GO:0030335 GO:0032332 GO:0010718 GO:0051894 GO:1901313 GO:0032731 GO:0050927 GO:0051496 GO:0042993 GO:0045944 GO:0045893 GO:0032916 GO:0050821 GO:0051098 GO:0050678 GO:0050776 GO:0016202 GO:0017015 GO:0032909 GO:0001666 GO:0023019 GO:0001501 GO:0007183 GO:0060395 GO:0001756 GO:0042110 GO:0030878 GO:0006366 GO:0060290 GO:0007179 GO:0006810 GO:0001657
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:24964035^[1]	ECO:0000353	physical interaction evidence used in manual assertion	ENSEMBL_GeneID:ENSG00000127445	F	has_input:(ENSEMBL:ENSMUSG00000032171) occurs_at:(SO:0000170)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25065622^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0050862) occurs_in:(CL:0000084) has_regulation_target:(UniProtKB:O08573)\|occurs_in(CL:0000895) has_regulation_target:(UniProtKB:O08573) has_regulation_target:(UniProtKB:Q99JB6) occurs_in:(CL:0000902)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:25065622^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000039521) occurs_in:(CL:0000902)\|has_direct_input(ENSEMBL:ENSMUSG00000001123) occurs_in:(CL:0000902)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:16224064^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	PMID:14617288^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	PMID:10559937^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	PMID:21035443^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	PMID:10064594^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:10559937^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:10064594^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033689	negative regulation of osteoblast proliferation	PMID:21035443^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:21035443^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11937490^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B7ZQJ9	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11160896^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11160896^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:14656760^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:11585338^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901203	positive regulation of extracellular matrix assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
part_of	GO:0071144	heteromeric SMAD protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070306	lens fiber cell differentiation	PMID:17215516^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000306)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061767	negative regulation of lung blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	PMID:23390484^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060290	transdifferentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060039	pericardium development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051098	regulation of binding	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050678	regulation of epithelial cell proliferation	PMID:12845704^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857695	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048340	paraxial mesoderm morphogenesis	PMID:15084457^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857696	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21724602^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23390484^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17159989^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051 MGI:MGI:1314872 MGI:MGI:894293 MGI:MGI:98727	P	has_regulation_target:(MGI:MGI:3616404)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16824956^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106658 MGI:MGI:1344313	P	has_regulation_target:(MGI:MGI:87909)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15150273^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16619037^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15150273^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12943993^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15464984^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:15150273^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045216	cell-cell junction organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21724602^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038092	nodal signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032924	activin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032916	positive regulation of transforming growth factor beta3 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
enables	GO:0031962	mineralocorticoid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030878	thyroid gland development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030325	adrenal gland development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019049	evasion or tolerance of host defenses by virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	PMID:11711431^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016202	regulation of striated muscle tissue development	PMID:11711431^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010694	positive regulation of alkaline phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007369	gastrulation	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007183	SMAD protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007183	SMAD protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:15239668^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21937600^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:16619037^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:15239668^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12543979^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12943993^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	PMID:14559231^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08121 UniProtKB:Q01149 UniProtKB:Q3U962	F		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12943993^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16619037^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002520	immune system development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:15150273^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:15183723^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:15084457^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857696	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:15183723^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9702197^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11711431^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P84022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3032	P		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0061767	negative regulation of lung blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0060290	transdifferentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	C		Seeded From UniProt	complete
involved_in	GO:0032916	positive regulation of transforming growth factor beta3 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84025 ensembl:ENSRNOP00000037346	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:1901203	positive regulation of extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
part_of	GO:0071144	heteromeric SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0038092	nodal signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0031962	mineralocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0019049	evasion or tolerance of host defenses by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P84022 ensembl:ENSP00000332973	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z3 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z3 ensembl:ENSP00000332973	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8774881^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:10823886^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9605444	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625492	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ueberham, U et al. (2014) Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 40 815-32 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, C et al. (2014) Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 270-82 PubMed GONUTS page
↑ Qiu, P et al. (2005) Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ. Res. 97 983-91 PubMed GONUTS page
↑ Ashcroft, GS et al. () Role of Smad3 in the hormonal modulation of in vivo wound healing responses. Wound Repair Regen 11 468-73 PubMed GONUTS page
↑ ^5.0 ^5.1 Ashcroft, GS et al. (1999) Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1 260-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kawakatsu, M et al. (2011) Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing. Exp. Mol. Pathol. 90 107-15 PubMed GONUTS page
↑ ^7.0 ^7.1 Yang, X et al. (1999) Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18 1280-91 PubMed GONUTS page
↑ Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page
↑ ^9.0 ^9.1 Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page
↑ Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page
↑ Borton, AJ et al. (2001) The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J. Bone Miner. Res. 16 1754-64 PubMed GONUTS page
↑ Wu, G et al. (2007) The anaphase-promoting complex coordinates initiation of lens differentiation. Mol. Biol. Cell 18 1018-29 PubMed GONUTS page
↑ ^13.0 ^13.1 Redshaw, N et al. (2013) TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. PLoS ONE 8 e55186 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Liu, Y et al. (2004) Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev. Biol. 270 411-26 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page
↑ Symonds, D et al. (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol 273 681-6 PubMed GONUTS page
↑ ^17.0 ^17.1 Dunn, NR et al. (2004) Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development 131 1717-28 PubMed GONUTS page
↑ ^18.0 ^18.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page
↑ Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page
↑ Nishimura, G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev. Cell 11 93-104 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Ellsworth, BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol. Cell. Endocrinol. 206 93-111 PubMed GONUTS page
↑ Warner, DR et al. (2004) Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochem. Biophys. Res. Commun. 324 70-6 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Liu, D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 15 2950-66 PubMed GONUTS page
↑ ^26.0 ^26.1 Piek, E et al. (2004) RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Biochem. J. 383 187-99 PubMed GONUTS page
↑ Wang, B et al. (2011) Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development 138 4487-97 PubMed GONUTS page
↑ Tang, Y et al. (2003) Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 299 574-7 PubMed GONUTS page
↑ Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page
↑ Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
↑ Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page
↑ Denissova, NG et al. (2000) Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. U.S.A. 97 6397-402 PubMed GONUTS page

[PMID:24964035-1] Ueberham, U et al. (2014) Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 40 815-32 PubMed GONUTS page

[PMID:25065622-2] 2.0 ^2.1 Wu, C et al. (2014) Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 270-82 PubMed GONUTS page

[PMID:16224064-3] Qiu, P et al. (2005) Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ. Res. 97 983-91 PubMed GONUTS page

[PMID:14617288-4] Ashcroft, GS et al. () Role of Smad3 in the hormonal modulation of in vivo wound healing responses. Wound Repair Regen 11 468-73 PubMed GONUTS page

[PMID:10559937-5] 5.0 ^5.1 Ashcroft, GS et al. (1999) Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1 260-6 PubMed GONUTS page

[PMID:21035443-6] 6.0 ^6.1 ^6.2 Kawakatsu, M et al. (2011) Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing. Exp. Mol. Pathol. 90 107-15 PubMed GONUTS page

[PMID:10064594-7] 7.0 ^7.1 Yang, X et al. (1999) Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18 1280-91 PubMed GONUTS page

[PMID:11937490-8] Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page

[PMID:11160896-9] 9.0 ^9.1 Quinn, ZA et al. (2001) Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 29 732-42 PubMed GONUTS page

[PMID:14656760-10] Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page

[PMID:11585338-11] Borton, AJ et al. (2001) The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J. Bone Miner. Res. 16 1754-64 PubMed GONUTS page

[PMID:17215516-12] Wu, G et al. (2007) The anaphase-promoting complex coordinates initiation of lens differentiation. Mol. Biol. Cell 18 1018-29 PubMed GONUTS page

[PMID:23390484-13] 13.0 ^13.1 Redshaw, N et al. (2013) TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. PLoS ONE 8 e55186 PubMed GONUTS page

[PMID:15183723-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Liu, Y et al. (2004) Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev. Biol. 270 411-26 PubMed GONUTS page

[PMID:15282343-15] 15.0 ^15.1 ^15.2 ^15.3 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page

[PMID:12845704-16] Symonds, D et al. (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol 273 681-6 PubMed GONUTS page

[PMID:15084457-17] 17.0 ^17.1 Dunn, NR et al. (2004) Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development 131 1717-28 PubMed GONUTS page

[PMID:21724602-18] 18.0 ^18.1 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page

[PMID:17159989-19] Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page

[PMID:16824956-20] Nishimura, G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev. Cell 11 93-104 PubMed GONUTS page

[PMID:15150273-21] 21.0 ^21.1 ^21.2 ^21.3 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page

[PMID:16619037-22] 22.0 ^22.1 ^22.2 Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page

[PMID:12943993-23] 23.0 ^23.1 ^23.2 Ellsworth, BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol. Cell. Endocrinol. 206 93-111 PubMed GONUTS page

[PMID:15464984-24] Warner, DR et al. (2004) Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochem. Biophys. Res. Commun. 324 70-6 PubMed GONUTS page

[PMID:11711431-25] 25.0 ^25.1 ^25.2 Liu, D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 15 2950-66 PubMed GONUTS page

[PMID:15239668-26] 26.0 ^26.1 Piek, E et al. (2004) RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Biochem. J. 383 187-99 PubMed GONUTS page

[PMID:21937600-27] Wang, B et al. (2011) Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development 138 4487-97 PubMed GONUTS page

[PMID:12543979-28] Tang, Y et al. (2003) Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 299 574-7 PubMed GONUTS page

[PMID:14559231-29] Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page

[PMID:9702197-30] Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page

[PMID:8774881-31] Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page

[PMID:10823886-32] Denissova, NG et al. (2000) Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. U.S.A. 97 6397-402 PubMed GONUTS page

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MOUSE:SMAD3

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