MOUSE:SMAD5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad5 (synonyms: Madh5, Msmad5)
Protein Name(s)	Mothers against decapentaplegic homolog 5 MAD homolog 5 Mothers against DPP homolog 5 Dwarfin-C Dwf-C SMAD family member 5 SMAD 5 Smad5 mSmad5
External Links
UniProt	P97454
EMBL	U58993 U77638 AF063006 AK082997 BC050001
CCDS	CCDS26565.1
RefSeq	NP_001157513.1 NP_001157514.1 NP_032567.1 XP_006517180.1 XP_006517181.1
UniGene	Mm.272920
ProteinModelPortal	P97454
SMR	P97454
BioGrid	201278
IntAct	P97454
MINT	MINT-99279
PhosphoSite	P97454
MaxQB	P97454
PaxDb	P97454
PRIDE	P97454
Ensembl	ENSMUST00000069557 ENSMUST00000109874 ENSMUST00000109876
GeneID	17129
KEGG	mmu:17129
UCSC	uc007qsw.2
CTD	4090
MGI	MGI:1328787
eggNOG	NOG330956
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286018
HOVERGEN	HBG053353
InParanoid	P97454
KO	K16790
OMA	DVQPVEY
OrthoDB	EOG7W1540
PhylomeDB	P97454
TreeFam	TF314923
Reactome	REACT_220505
NextBio	291320
PRO	PR:P97454
Proteomes	UP000000589
Bgee	P97454
CleanEx	MM_SMAD5
Genevestigator	P97454
GO	GO:0005737 GO:0005634 GO:0043234 GO:0005667 GO:0046872 GO:0000979 GO:0003700 GO:0001525 GO:0030509 GO:0060348 GO:0060048 GO:0051216 GO:0071773 GO:0071407 GO:0009880 GO:0030218 GO:0007281 GO:0001880 GO:0002051 GO:0045669 GO:0045944 GO:1901522 GO:0006468 GO:0006351 GO:0007179 GO:0001657
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000122,GO:0000977	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:22964636^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:18590)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:11729207^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(NCBI_Gene:15901)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19252488^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P20722	P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:19252488^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P20722	P	occurs_in:(UBERON:0002107) part_of:(GO:0030509)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19252488^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19252488^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	PMID:20843790^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70340	P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:20843790^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70340	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:20843790^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70340	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12151307^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:14656760^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19103752^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060348	bone development	PMID:19224984^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109452 MGI:MGI:1859993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	PMID:17456754^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679443	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051216	cartilage development	PMID:19224984^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109452 MGI:MGI:1859993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15557274^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96429)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15150273^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99717	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99717	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19224984^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109452 MGI:MGI:1859993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:18590716^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030218	erythrocyte differentiation	PMID:15591122^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99717	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:11404080^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16190) results_in_development_of:(CL:0000670)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11376112^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18776146^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99717	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19103752^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99717	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19793887^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19103752^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002051	osteoblast fate commitment	PMID:15150273^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001880	Mullerian duct regression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620158	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18692037^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:2661061) occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68DB7 ensembl:ENSP00000441954	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68DB7 ensembl:ENSP00000441954	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99717 ensembl:ENSP00000441954	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99717 ensembl:ENSP00000441954	F		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99717 ensembl:ENSP00000441954	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99717 ensembl:ENSP00000441954	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99717 ensembl:ENSP00000441954	C		Seeded From UniProt	complete
involved_in	GO:0001880	Mullerian duct regression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1V3 ensembl:ENSRNOP00000016704	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1V3 ensembl:ENSRNOP00000016704	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:12370310^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tripurani, SK et al. (2013) BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. Oncogene 32 3877-85 PubMed GONUTS page
↑ Korchynskyi, O & ten Dijke, P (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277 4883-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cho, YD et al. (2010) The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J. Biol. Chem. 285 36369-76 PubMed GONUTS page
↑ Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page
↑ Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Retting, KN et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 136 1093-104 PubMed GONUTS page
↑ Umans, L et al. (2007) Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am. J. Pathol. 170 1460-72 PubMed GONUTS page
↑ Liu, CJ et al. (2005) The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J. Biol. Chem. 280 2788-96 PubMed GONUTS page
↑ ^11.0 ^11.1 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ Lenox, LE et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105 2741-8 PubMed GONUTS page
↑ Chang, H & Matzuk, MM (2001) Smad5 is required for mouse primordial germ cell development. Mech. Dev. 104 61-7 PubMed GONUTS page
↑ Visser, JA et al. (2001) The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol. Endocrinol. 15 936-45 PubMed GONUTS page
↑ Caubit, X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135 3301-10 PubMed GONUTS page
↑ Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page
↑ Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page
↑ Jiao, K et al. (2002) Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Mol. Cell. Biol. 22 7633-44 PubMed GONUTS page

[PMID:22964636-1] Tripurani, SK et al. (2013) BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. Oncogene 32 3877-85 PubMed GONUTS page

[PMID:11729207-2] Korchynskyi, O & ten Dijke, P (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277 4883-91 PubMed GONUTS page

[PMID:19252488-3] 3.0 ^3.1 ^3.2 ^3.3 Meynard, D et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41 478-81 PubMed GONUTS page

[PMID:20843790-4] 4.0 ^4.1 ^4.2 Cho, YD et al. (2010) The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J. Biol. Chem. 285 36369-76 PubMed GONUTS page

[PMID:12151307-5] Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page

[PMID:14656760-6] Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page

[PMID:19103752-7] 7.0 ^7.1 ^7.2 Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page

[PMID:19224984-8] 8.0 ^8.1 ^8.2 Retting, KN et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 136 1093-104 PubMed GONUTS page

[PMID:17456754-9] Umans, L et al. (2007) Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am. J. Pathol. 170 1460-72 PubMed GONUTS page

[PMID:15557274-10] Liu, CJ et al. (2005) The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J. Biol. Chem. 280 2788-96 PubMed GONUTS page

[PMID:15150273-11] 11.0 ^11.1 Sowa, H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J. Biol. Chem. 279 40267-75 PubMed GONUTS page

[PMID:23610558-12] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:18590716-13] Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

[PMID:15591122-14] Lenox, LE et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105 2741-8 PubMed GONUTS page

[PMID:11404080-15] Chang, H & Matzuk, MM (2001) Smad5 is required for mouse primordial germ cell development. Mech. Dev. 104 61-7 PubMed GONUTS page

[PMID:11376112-16] Visser, JA et al. (2001) The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol. Endocrinol. 15 936-45 PubMed GONUTS page

[PMID:18776146-17] Caubit, X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135 3301-10 PubMed GONUTS page

[PMID:19793887-18] Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page

[PMID:18692037-19] Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page

[PMID:12370310-20] Jiao, K et al. (2002) Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Mol. Cell. Biol. 22 7633-44 PubMed GONUTS page

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MOUSE:SMAD5

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