HUMAN:BMP5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BMP5
Protein Name(s)	Bone morphogenetic protein 5 BMP-5
External Links
UniProt	P22003
EMBL	M60314 AK303576 AL133386 AL137178 AL137178 AL133386 BC027958
CCDS	CCDS4958.1
PIR	A39263
RefSeq	NP_066551.1
UniGene	Hs.296648
ProteinModelPortal	P22003
SMR	P22003
STRING	9606.ENSP00000359866
PhosphoSite	P22003
DMDM	115075
PaxDb	P22003
PRIDE	P22003
DNASU	653
Ensembl	ENST00000370830
GeneID	653
KEGG	hsa:653
UCSC	uc003pcq.3
CTD	653
GeneCards	GC06M055667
HGNC	HGNC:1072
MIM	112265
neXtProt	NX_P22003
PharmGKB	PA25382
eggNOG	NOG272883
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249476
HOVERGEN	HBG004860
InParanoid	P22003
KO	K04663
OMA	FRIYKDQ
OrthoDB	EOG7J9VPQ
PhylomeDB	P22003
TreeFam	TF316134
GeneWiki	Bone_morphogenetic_protein_5
GenomeRNAi	653
NextBio	2656
PRO	PR:P22003
Proteomes	UP000005640
Bgee	P22003
CleanEx	HS_BMP5
ExpressionAtlas	P22003
Genevestigator	P22003
GO	GO:0005615 GO:0031988 GO:0070700 GO:0051216 GO:0040007 GO:0030539 GO:0032348 GO:0008285 GO:2000065 GO:0010719 GO:1902042 GO:0043569 GO:0071676 GO:0010894 GO:0001503 GO:0007389 GO:1900006 GO:2000105 GO:0050679 GO:0010862 GO:0045944 GO:0001501 GO:0003323
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:1905069	allantois development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0061384	heart trabecula morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49003	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15516325^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000065	negative regulation of cortisol biosynthetic process	PMID:19584291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:21319131^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0071356)	Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	PMID:11580864^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000111)	Seeded From UniProt	complete
involved_in	GO:0071676	negative regulation of mononuclear cell migration	PMID:21319131^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0071356)	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:11865031^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0031016) occurs_in:(CL:0002079)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15516325^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13950)\|has_regulation_target:(UniProtKB:P10451)\|has_regulation_target:(UniProtKB:P12643)	Seeded From UniProt	complete
involved_in	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	PMID:19584291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032348	negative regulation of aldosterone biosynthetic process	PMID:19584291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A7P9	C		Seeded From UniProt	complete
involved_in	GO:0010894	negative regulation of steroid biosynthetic process	PMID:19584291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:11580864^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797) happens_during:(GO:0016358)	Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:21319131^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:19584291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A7P9	C		Seeded From UniProt	complete
involved_in	GO:0003323	type B pancreatic cell development	PMID:11865031^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:2263636^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000932177 UniProtKB:P22003 UniProtKB:P22004	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:88182 PANTHER:PTN000932177 UniProtKB:P18075 UniProtKB:P22004	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:7811286^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A7P9 ensembl:ENSRNOP00000014846	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A7P9 ensembl:ENSRNOP00000014846	C		Seeded From UniProt	complete
involved_in	GO:1905069	allantois development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0097065	anterior head development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0061384	heart trabecula morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49003 ensembl:ENSMUSP00000012281	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Xu, WP et al. (2004) Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol. Int. 28 675-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Johnsen, IK et al. (2009) Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis. Cancer Res. 69 5784-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bramlage, CP et al. () The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. J. Nephrol. 24 647-55 PubMed GONUTS page
↑ ^4.0 ^4.1 Beck, HN et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci 2 12 PubMed GONUTS page
↑ ^5.0 ^5.1 Jiang, FX et al. (2002) Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J. Cell. Sci. 115 753-60 PubMed GONUTS page
↑ Celeste, AJ et al. (1990) Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci. U.S.A. 87 9843-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

[PMID:15516325-1] 1.0 ^1.1 Xu, WP et al. (2004) Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol. Int. 28 675-82 PubMed GONUTS page

[PMID:19584291-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Johnsen, IK et al. (2009) Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis. Cancer Res. 69 5784-92 PubMed GONUTS page

[PMID:21319131-3] 3.0 ^3.1 ^3.2 Bramlage, CP et al. () The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. J. Nephrol. 24 647-55 PubMed GONUTS page

[PMID:11580864-4] 4.0 ^4.1 Beck, HN et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci 2 12 PubMed GONUTS page

[PMID:11865031-5] 5.0 ^5.1 Jiang, FX et al. (2002) Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J. Cell. Sci. 115 753-60 PubMed GONUTS page

[PMID:2263636-6] Celeste, AJ et al. (1990) Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci. U.S.A. 87 9843-7 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7811286-8] Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

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HUMAN:BMP5

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