RAT:TGFB1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tgfb1
Protein Name(s)	Transforming growth factor beta-1 TGF-beta-1 Latency-associated peptide LAP
External Links
UniProt	P17246
EMBL	X52498 AY550025 BC076380
PIR	S10219
RefSeq	NP_067589.1
UniGene	Rn.40136
ProteinModelPortal	P17246
SMR	P17246
BioGrid	248721
DIP	DIP-6247N
PaxDb	P17246
PRIDE	P17246
Ensembl	ENSRNOT00000028051
GeneID	59086
KEGG	rno:59086
UCSC	RGD:69051
CTD	7040
RGD	69051
eggNOG	NOG279949
GeneTree	ENSGT00760000119112
HOGENOM	HOG000290198
HOVERGEN	HBG074115
InParanoid	P17246
KO	K13375
OMA	SHSIYMF
OrthoDB	EOG70GMFT
PhylomeDB	P17246
TreeFam	TF318514
Reactome	REACT_194641 REACT_194651 REACT_194652 REACT_194657 REACT_194661 REACT_194666 REACT_194677 REACT_194682 REACT_198300 REACT_198592 REACT_198757 REACT_198828 REACT_260360
NextBio	611708
PRO	PR:P17246
Proteomes	UP000002494
ExpressionAtlas	P17246
Genevestigator	P17246
GO	GO:0030424 GO:0072562 GO:0009986 GO:0005737 GO:0005615 GO:0005902 GO:0043025 GO:0005634 GO:0005578 GO:0030141 GO:0003823 GO:0046982 GO:0042803 GO:0047485 GO:0005160 GO:0005114 GO:0002460 GO:0007568 GO:0006754 GO:0060751 GO:0007050 GO:0016049 GO:0045216 GO:0006874 GO:0071549 GO:0071407 GO:0002062 GO:0007182 GO:0009817 GO:0048565 GO:0007492 GO:0007173 GO:0001837 GO:0019049 GO:0085029 GO:0097191 GO:0060325 GO:0007565 GO:0060364 GO:0008354 GO:0002244 GO:0030214 GO:0006954 GO:0048839 GO:0070306 GO:0031663 GO:0030324 GO:0048535 GO:0060744 GO:0000165 GO:0007093 GO:0032943 GO:0001763 GO:0042552 GO:0043011 GO:0043537 GO:0045786 GO:0030308 GO:0008285 GO:0022408 GO:0008156 GO:0050680 GO:0045599 GO:1900126 GO:0050777 GO:0010936 GO:0045930 GO:0045662 GO:0007406 GO:0030279 GO:0050765 GO:0001933 GO:0051280 GO:0048642 GO:0042130 GO:0000122 GO:0045892 GO:0031100 GO:0043932 GO:0060389 GO:0006796 GO:0043065 GO:0043536 GO:0030501 GO:0090190 GO:0071158 GO:0030335 GO:0008284 GO:0032270 GO:0050921 GO:0032967 GO:0050679 GO:0010718 GO:0031536 GO:0010763 GO:0010628 GO:0035066 GO:0031065 GO:0032740 GO:0048298 GO:0043406 GO:1901666 GO:0051092 GO:0042482 GO:0010862 GO:0033138 GO:0010800 GO:0043552 GO:0031334 GO:0035307 GO:0051897 GO:0001934 GO:0050714 GO:0060391 GO:0051152 GO:0032930 GO:0045944 GO:2000679 GO:0045893 GO:0006611 GO:0000060 GO:0043491 GO:0032801 GO:2000249 GO:0060762 GO:0061035 GO:0001558 GO:0042127 GO:2000628 GO:0002028 GO:0017015 GO:0045066 GO:0070723 GO:0042493 GO:0032355 GO:0009749 GO:0001666 GO:0034616 GO:0014070 GO:0010033 GO:0032570 GO:0009314 GO:0033280 GO:0007435 GO:0007183 GO:0007184 GO:0043029 GO:0002513 GO:0007179 GO:0001657 GO:0042060
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR016319 IPR015615 IPR003939 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PIRSF	PIRSF001787
PRINTS	PR01423 PR01424
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006468	protein phosphorylation	PMID:23393573^[1]	ECO:0000314			P	According to Figure 8b, there was a 67%increase in phosphorylated FOXO1 in TGF- beta 1 treated cells compared to the levels in control treated cells. Moreover, Phosphorylation of FOXO1 in TGF-Beta 1 treated cells was inhibited in cells pretreated with P13K inhibitor.	complete CACAO 7662
involved_in	GO:0014008	positive regulation of microglia differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04202	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0060390	regulation of SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23393573^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043932	ossification involved in bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0048298	positive regulation of isotype switching to IgA isotypes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	F	Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	F	Seeded From UniProt	complete
enables	GO:0003823	antigen binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	F	Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	C	Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10487979^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	C	Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:1901666	positive regulation of NAD+ ADP-ribosyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:1900126	negative regulation of hyaluronan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:17537984^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	PMID:17537984^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0048642	negative regulation of skeletal muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0035307	positive regulation of protein dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0030214	hyaluronan catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0019049	evasion or tolerance of host defenses by virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007182	common-partner SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0006796	phosphate-containing compound metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0006754	ATP biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
colocalizes_with	GO:0005902	microvillus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	C	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	F	Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01137	P	Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	PMID:25335926^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902074	response to salt	PMID:23249995^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:25862490^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071677	positive regulation of mononuclear cell migration	PMID:26923362^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:25600523^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:24120154^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:24224514^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060364	frontal suture morphogenesis	PMID:12416537^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	PMID:12876066^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15781474^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050777	negative regulation of immune response	PMID:12130550^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	PMID:16272332^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:15192047^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:15192047^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:16479080^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:12815632^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:8106553^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18406405^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16532270^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16157589^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:15214860^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18406405^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042552	myelination	PMID:14648590^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:19406119^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18291259^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:11597910^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:17117936^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:17352758^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:12533868^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	PMID:25641164^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	PMID:16217485^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	PMID:24613393^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	PMID:11956143^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	PMID:26923362^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:15746252^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031536	positive regulation of exit from mitosis	PMID:16177030^[36]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:9699514^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15214860^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:15214860^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:15746252^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:12223100^[38]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009817	defense response to fungus, incompatible interaction	PMID:16272332^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:18587447^[39]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:11774400^[40]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:12051734^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:15927076^[42]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007406	negative regulation of neuroblast proliferation	PMID:16177030^[36]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11774400^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16837651^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:10504497^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001763	morphogenesis of a branching structure	PMID:15192047^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:17213961^[45]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0051152	positive regulation of smooth muscle cell differentiation	PMID:8616889^[47]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1903077	negative regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1901666	positive regulation of NAD+ ADP-ribosyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:1900126	negative regulation of hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0070168	negative regulation of biomineral tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0060965	negative regulation of gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0060390	regulation of SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0048642	negative regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0048298	positive regulation of isotype switching to IgA isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045918	negative regulation of cytolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043932	ossification involved in bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0035307	positive regulation of protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0030214	hyaluronan catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
involved_in	GO:0019049	evasion or tolerance of host defenses by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	C	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007182	common-partner SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0006796	phosphate-containing compound metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0006754	ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	C	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
enables	GO:0003823	antigen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	F	Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01137 ensembl:ENSP00000221930	P	Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:1990402	embryonic liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:1905313	transforming growth factor beta receptor signaling pathway involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:1903911	positive regulation of receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0070168	negative regulation of biomineral tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0061448	connective tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0061035	regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0060751	branch elongation involved in mammary gland duct branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0060744	mammary gland branching involved in thelarche	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0051101	regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0051098	regulation of binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0050868	negative regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0048535	lymph node development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0045591	positive regulation of regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0045589	regulation of regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0045066	regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	F	Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0042482	positive regulation of odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0042306	regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0032943	mononuclear cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0032667	regulation of interleukin-23 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	C	Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0016202	regulation of striated muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0014008	positive regulation of microglia differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0014003	oligodendrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	F	Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0003179	heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0002513	tolerance induction to self antigen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0001775	cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04202 ensembl:ENSMUSP00000002678	P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003939	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016319	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:12225958^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:7852342^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:7852342^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:12225958^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kaur, K et al. (2013) TGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes. PLoS ONE 8 e55391 PubMed GONUTS page
↑ Yehualaeshet, T et al. (1999) Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Am. J. Pathol. 155 841-51 PubMed GONUTS page
↑ ^3.0 ^3.1 Singh, RR et al. (2007) Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Am. J. Physiol. Renal Physiol. 293 F548-54 PubMed GONUTS page
↑ Hiney, JK et al. (2014) Alcohol alters insulin-like growth factor-1-induced transforming growth factor β1 synthesis in the medial basal hypothalamus of the prepubertal female rat. Alcohol. Clin. Exp. Res. 38 2572-8 PubMed GONUTS page
↑ Chen, CC et al. (2013) Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. Physiol. Genomics 45 110-8 PubMed GONUTS page
↑ Lee, SC et al. (2015) Role of the spleen in liver regeneration in relation to transforming growth factor-β1 and hepatocyte growth factor. J. Surg. Res. 196 270-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, H et al. (2016) Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle. Biomaterials 87 147-156 PubMed GONUTS page
↑ Burrell, CG et al. () Effect of radiation and repeated sub-culturing on the transforming growth factor-β1 signaling pathway in FRTL-5 cells. In Vivo 29 5-15 PubMed GONUTS page
↑ Wang, BW et al. (2013) Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes. J. Formos. Med. Assoc. 112 635-43 PubMed GONUTS page
↑ Li, S et al. (2014) Immunohistochemical localization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-smad2/3 in the developing periodontium of rats. J. Periodont. Res. 49 624-33 PubMed GONUTS page
↑ Adab, K et al. (2002) Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Orthod Craniofac Res 5 227-37 PubMed GONUTS page
↑ Sharma, K et al. (2003) Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am. J. Physiol. Renal Physiol. 285 F1258-70 PubMed GONUTS page
↑ König, HG et al. (2005) TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell Biol. 168 1077-86 PubMed GONUTS page
↑ Wira, CR et al. (2002) Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation. Endocrinology 143 2872-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Shao, X et al. (2005) A dual role for TGF-beta1 in the control and persistence of fungal pneumonia. J. Immunol. 175 6757-63 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Tomlinson, DC et al. (2004) Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate. Endocrinology 145 4292-300 PubMed GONUTS page
↑ Kim, HJ et al. (2006) Expression of TGFbeta family in the developing internal ear of rat embryos. J. Korean Med. Sci. 21 136-42 PubMed GONUTS page
↑ de Andrade Sá, ER et al. (2003) Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. Dev. Dyn. 227 450-7 PubMed GONUTS page
↑ López-Casillas, F et al. (1994) Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell Biol. 124 557-68 PubMed GONUTS page
↑ ^20.0 ^20.1 Anjaneyulu, M et al. (2008) Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Exp. Neurol. 211 469-79 PubMed GONUTS page
↑ Konrad, L et al. (2006) Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis 11 739-48 PubMed GONUTS page
↑ Kaur, S et al. (2005) X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). J. Biol. Chem. 280 38599-608 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Fèvre-Montange, M et al. (2004) Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. J. Neuroendocrinol. 16 571-6 PubMed GONUTS page
↑ Diemel, LT et al. (2003) Role for TGF-beta1, FGF-2 and PDGF-AA in a myelination of CNS aggregate cultures enriched with macrophages. J. Neurosci. Res. 74 858-67 PubMed GONUTS page
↑ Halici, Z et al. (2009) Does telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes? Eur. J. Pharmacol. 614 146-52 PubMed GONUTS page
↑ Liu, KH et al. (2008) Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats. Surgery 143 375-83 PubMed GONUTS page
↑ Chung, WH et al. (2001) Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 281 L1180-8 PubMed GONUTS page
↑ Atkins, S et al. (2006) The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. J. Peripher. Nerv. Syst. 11 286-93 PubMed GONUTS page
↑ Manolis, EN et al. () Tissue concentration of transforming growth factor beta1 and basic fibroblast growth factor in skin wounds created with a CO2 laser and scalpel: a comparative experimental study, using an animal model of skin resurfacing. Wound Repair Regen 15 252-7 PubMed GONUTS page
↑ Wang, HJ et al. (2001) [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]. Fa Yi Xue Za Zhi 17 198-201, 204 PubMed GONUTS page
↑ Honda, Y et al. (2015) Upregulation of interleukin-1β/transforming growth factor-β1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture. Muscle Nerve 52 419-27 PubMed GONUTS page
↑ Fong, KD et al. (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116 1393-404; discussion 1405-6 PubMed GONUTS page
↑ Wang, L et al. (2014) The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes. Diabetes Res. Clin. Pract. 104 226-33 PubMed GONUTS page
↑ Peleg, S et al. (2002) Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats. Endocrinology 143 1625-36 PubMed GONUTS page
↑ ^35.0 ^35.1 Dhandapani, KM et al. (2005) Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology 146 2749-59 PubMed GONUTS page
↑ ^36.0 ^36.1 Siegenthaler, JA & Miller, MW (2005) Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. J. Neurosci. 25 8627-36 PubMed GONUTS page
↑ Nishikawa, Y et al. (1998) Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. J. Cell. Physiol. 176 612-23 PubMed GONUTS page
↑ Chen, A (2002) Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem. J. 368 683-93 PubMed GONUTS page
↑ Li, X et al. (2008) Urocortin ameliorates diabetic nephropathy in obese db/db mice. Br. J. Pharmacol. 154 1025-34 PubMed GONUTS page
↑ ^40.0 ^40.1 Schultze-Mosgau, S et al. (2002) Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Head Neck 24 33-41 PubMed GONUTS page
↑ Zhao, H et al. (2002) Transforming growth factor-beta(s) and their receptors in aging rat prostate. Biochem. Biophys. Res. Commun. 294 464-9 PubMed GONUTS page
↑ Shooner, C et al. (2005) TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod. Biol. Endocrinol. 3 20 PubMed GONUTS page
↑ Aoki, H et al. (2007) Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines. Am. J. Physiol., Cell Physiol. 292 C259-68 PubMed GONUTS page
↑ Fan, JM et al. (1999) Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int. 56 1455-67 PubMed GONUTS page
↑ Jiang, Y et al. (2007) Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha. Acta Biochim. Biophys. Sin. (Shanghai) 39 73-80 PubMed GONUTS page
↑ ^46.00 ^46.01 ^46.02 ^46.03 ^46.04 ^46.05 ^46.06 ^46.07 ^46.08 ^46.09 ^46.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shah, NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 331-43 PubMed GONUTS page
↑ ^48.0 ^48.1 Venkatesan, N et al. (2002) Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L806-14 PubMed GONUTS page
↑ ^49.0 ^49.1 Wang, J et al. (1995) Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. J. Biol. Chem. 270 2722-8 PubMed GONUTS page

[PMID:23393573-1] 1.0 ^1.1 Kaur, K et al. (2013) TGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes. PLoS ONE 8 e55391 PubMed GONUTS page

[PMID:10487979-2] Yehualaeshet, T et al. (1999) Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Am. J. Pathol. 155 841-51 PubMed GONUTS page

[PMID:17537984-3] 3.0 ^3.1 Singh, RR et al. (2007) Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Am. J. Physiol. Renal Physiol. 293 F548-54 PubMed GONUTS page

[PMID:25335926-4] Hiney, JK et al. (2014) Alcohol alters insulin-like growth factor-1-induced transforming growth factor β1 synthesis in the medial basal hypothalamus of the prepubertal female rat. Alcohol. Clin. Exp. Res. 38 2572-8 PubMed GONUTS page

[PMID:23249995-5] Chen, CC et al. (2013) Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. Physiol. Genomics 45 110-8 PubMed GONUTS page

[PMID:25862490-6] Lee, SC et al. (2015) Role of the spleen in liver regeneration in relation to transforming growth factor-β1 and hepatocyte growth factor. J. Surg. Res. 196 270-7 PubMed GONUTS page

[PMID:26923362-7] 7.0 ^7.1 Li, H et al. (2016) Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle. Biomaterials 87 147-156 PubMed GONUTS page

[PMID:25600523-8] Burrell, CG et al. () Effect of radiation and repeated sub-culturing on the transforming growth factor-β1 signaling pathway in FRTL-5 cells. In Vivo 29 5-15 PubMed GONUTS page

[PMID:24120154-9] Wang, BW et al. (2013) Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes. J. Formos. Med. Assoc. 112 635-43 PubMed GONUTS page

[PMID:24224514-10] Li, S et al. (2014) Immunohistochemical localization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-smad2/3 in the developing periodontium of rats. J. Periodont. Res. 49 624-33 PubMed GONUTS page

[PMID:12416537-11] Adab, K et al. (2002) Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Orthod Craniofac Res 5 227-37 PubMed GONUTS page

[PMID:12876066-12] Sharma, K et al. (2003) Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am. J. Physiol. Renal Physiol. 285 F1258-70 PubMed GONUTS page

[PMID:15781474-13] König, HG et al. (2005) TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell Biol. 168 1077-86 PubMed GONUTS page

[PMID:12130550-14] Wira, CR et al. (2002) Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation. Endocrinology 143 2872-9 PubMed GONUTS page

[PMID:16272332-15] 15.0 ^15.1 Shao, X et al. (2005) A dual role for TGF-beta1 in the control and persistence of fungal pneumonia. J. Immunol. 175 6757-63 PubMed GONUTS page

[PMID:15192047-16] 16.0 ^16.1 ^16.2 Tomlinson, DC et al. (2004) Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate. Endocrinology 145 4292-300 PubMed GONUTS page

[PMID:16479080-17] Kim, HJ et al. (2006) Expression of TGFbeta family in the developing internal ear of rat embryos. J. Korean Med. Sci. 21 136-42 PubMed GONUTS page

[PMID:12815632-18] Andrade Sá, ER et al. (2003) Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. Dev. Dyn. 227 450-7 PubMed GONUTS page

[PMID:8106553-19] López-Casillas, F et al. (1994) Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell Biol. 124 557-68 PubMed GONUTS page

[PMID:18406405-20] 20.0 ^20.1 Anjaneyulu, M et al. (2008) Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Exp. Neurol. 211 469-79 PubMed GONUTS page

[PMID:16532270-21] Konrad, L et al. (2006) Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis 11 739-48 PubMed GONUTS page

[PMID:16157589-22] Kaur, S et al. (2005) X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). J. Biol. Chem. 280 38599-608 PubMed GONUTS page

[PMID:15214860-23] 23.0 ^23.1 ^23.2 Fèvre-Montange, M et al. (2004) Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. J. Neuroendocrinol. 16 571-6 PubMed GONUTS page

[PMID:14648590-24] Diemel, LT et al. (2003) Role for TGF-beta1, FGF-2 and PDGF-AA in a myelination of CNS aggregate cultures enriched with macrophages. J. Neurosci. Res. 74 858-67 PubMed GONUTS page

[PMID:19406119-25] Halici, Z et al. (2009) Does telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes? Eur. J. Pharmacol. 614 146-52 PubMed GONUTS page

[PMID:18291259-26] Liu, KH et al. (2008) Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats. Surgery 143 375-83 PubMed GONUTS page

[PMID:11597910-27] Chung, WH et al. (2001) Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 281 L1180-8 PubMed GONUTS page

[PMID:17117936-28] Atkins, S et al. (2006) The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. J. Peripher. Nerv. Syst. 11 286-93 PubMed GONUTS page

[PMID:17352758-29] Manolis, EN et al. () Tissue concentration of transforming growth factor beta1 and basic fibroblast growth factor in skin wounds created with a CO2 laser and scalpel: a comparative experimental study, using an animal model of skin resurfacing. Wound Repair Regen 15 252-7 PubMed GONUTS page

[PMID:12533868-30] Wang, HJ et al. (2001) [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]. Fa Yi Xue Za Zhi 17 198-201, 204 PubMed GONUTS page

[PMID:25641164-31] Honda, Y et al. (2015) Upregulation of interleukin-1β/transforming growth factor-β1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture. Muscle Nerve 52 419-27 PubMed GONUTS page

[PMID:16217485-32] Fong, KD et al. (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116 1393-404; discussion 1405-6 PubMed GONUTS page

[PMID:24613393-33] Wang, L et al. (2014) The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes. Diabetes Res. Clin. Pract. 104 226-33 PubMed GONUTS page

[PMID:11956143-34] Peleg, S et al. (2002) Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats. Endocrinology 143 1625-36 PubMed GONUTS page

[PMID:15746252-35] 35.0 ^35.1 Dhandapani, KM et al. (2005) Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology 146 2749-59 PubMed GONUTS page

[PMID:16177030-36] 36.0 ^36.1 Siegenthaler, JA & Miller, MW (2005) Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. J. Neurosci. 25 8627-36 PubMed GONUTS page

[PMID:9699514-37] Nishikawa, Y et al. (1998) Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. J. Cell. Physiol. 176 612-23 PubMed GONUTS page

[PMID:12223100-38] Chen, A (2002) Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem. J. 368 683-93 PubMed GONUTS page

[PMID:18587447-39] Li, X et al. (2008) Urocortin ameliorates diabetic nephropathy in obese db/db mice. Br. J. Pharmacol. 154 1025-34 PubMed GONUTS page

[PMID:11774400-40] 40.0 ^40.1 Schultze-Mosgau, S et al. (2002) Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Head Neck 24 33-41 PubMed GONUTS page

[PMID:12051734-41] Zhao, H et al. (2002) Transforming growth factor-beta(s) and their receptors in aging rat prostate. Biochem. Biophys. Res. Commun. 294 464-9 PubMed GONUTS page

[PMID:15927076-42] Shooner, C et al. (2005) TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod. Biol. Endocrinol. 3 20 PubMed GONUTS page

[PMID:16837651-43] Aoki, H et al. (2007) Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines. Am. J. Physiol., Cell Physiol. 292 C259-68 PubMed GONUTS page

[PMID:10504497-44] Fan, JM et al. (1999) Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int. 56 1455-67 PubMed GONUTS page

[PMID:17213961-45] Jiang, Y et al. (2007) Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha. Acta Biochim. Biophys. Sin. (Shanghai) 39 73-80 PubMed GONUTS page

[PMID:21873635-46] 46.00 ^46.01 ^46.02 ^46.03 ^46.04 ^46.05 ^46.06 ^46.07 ^46.08 ^46.09 ^46.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8616889-47] Shah, NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 331-43 PubMed GONUTS page

[PMID:12225958-48] 48.0 ^48.1 Venkatesan, N et al. (2002) Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L806-14 PubMed GONUTS page

[PMID:7852342-49] 49.0 ^49.1 Wang, J et al. (1995) Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. J. Biol. Chem. 270 2722-8 PubMed GONUTS page

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