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PMID:11774400
| Citation |
Schultze-Mosgau, S, Wehrhan, F, Grabenbauer, G, Amann, K, Radespiel-Tröger, M, Neukam, FW and Rodel, F (2002) Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Head Neck 24:33-41 |
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| Abstract |
Following preoperative radiotherapy prior to ablative surgery of squamous epithelial carcinomas of the head and neck region, inflammatory changes and the expression of cytokines involved in wound healing could be observed. These processes lead to a delayed healing of free flaps in the graft bed. The aim of the present experimental study was to analyze the expression profiles of transforming growth factor (activated TGFbeta(1), TGFbeta(2)) and latency-associated peptide (LAP) in the irradiated graft beds and the transition area between grafts and irradiated graft beds. |
| Links | |
| Keywords |
Animals; Carcinoma, Squamous Cell/radiotherapy; Carcinoma, Squamous Cell/surgery; Chi-Square Distribution; Disease Models, Animal; Graft Rejection; Graft Survival/radiation effects; Head and Neck Neoplasms/radiotherapy; Head and Neck Neoplasms/surgery; Immunohistochemistry; Male; Preoperative Care; Probability; Rats; Rats, Wistar; Reference Values; Regression Analysis; Surgical Flaps/pathology; Transforming Growth Factor beta/analysis; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Wound Healing/physiology; Wound Healing/radiation effects |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009314: response to radiation |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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