GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:11774400

From GONUTS
Jump to: navigation, search
Citation

Schultze-Mosgau, S, Wehrhan, F, Grabenbauer, G, Amann, K, Radespiel-Tröger, M, Neukam, FW and Rodel, F (2002) Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Head Neck 24:33-41

Abstract

Following preoperative radiotherapy prior to ablative surgery of squamous epithelial carcinomas of the head and neck region, inflammatory changes and the expression of cytokines involved in wound healing could be observed. These processes lead to a delayed healing of free flaps in the graft bed. The aim of the present experimental study was to analyze the expression profiles of transforming growth factor (activated TGFbeta(1), TGFbeta(2)) and latency-associated peptide (LAP) in the irradiated graft beds and the transition area between grafts and irradiated graft beds.

Links

PubMed

Keywords

Animals; Carcinoma, Squamous Cell/radiotherapy; Carcinoma, Squamous Cell/surgery; Chi-Square Distribution; Disease Models, Animal; Graft Rejection; Graft Survival/radiation effects; Head and Neck Neoplasms/radiotherapy; Head and Neck Neoplasms/surgery; Immunohistochemistry; Male; Preoperative Care; Probability; Rats; Rats, Wistar; Reference Values; Regression Analysis; Surgical Flaps/pathology; Transforming Growth Factor beta/analysis; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Wound Healing/physiology; Wound Healing/radiation effects

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:TGFB1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:TGFB1

involved_in

GO:0009314: response to radiation

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.