Category:GO:0061630 ! ubiquitin protein ligase activity

name: ubiquitin protein ligase activity
namespace: molecular_function
alt_id: GO:0090302
alt_id: GO:0090622
alt_id: GO:1904264
alt_id: GO:1904822
def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]
comment: This enzyme catalyzes a transferase reaction.
synonym: "E3" BROAD [GOC:dph]
synonym: "ER-associated E3 ligase" RELATED [PMID:24019521]
synonym: "protein ubiquitination activity" EXACT [GOC:dph]
synonym: "ubiquitin ligase activity" EXACT [GOC:dph]
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

AmiGO <GOterm>GO:0061630</GOterm>
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