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HUMAN:RNF34
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RNF34 (ECO:0000312 with HGNC:HGNC:17297) | |
| Protein Name(s) | E3 ubiquitin-protein ligase RNF34 (ECO:0000305)
Caspase regulator CARP1 (ECO:0000305) Caspases-8 and -10-associated RING finger protein 1 (ECO:0000303 with PMID:15069192[1]) CARP-1 (ECO:0000303 with PMID:15069192[1]) FYVE-RING finger protein Momo (ECO:0000250 with UniProtKB:Q6AYH3) Human RING finger homologous to inhibitor of apoptosis protein (ECO:0000303 with PMID:12118383[2]) hRFI (ECO:0000303 with PMID:12118383[2]) RING finger protein 34 (ECO:0000312 with HGNC:HGNC:17297) RING finger protein RIFF (ECO:0000303 with Ref.2) | |
| External Links | ||
| UniProt | Q969K3 | |
| EMBL | AB084914 AF306709 AY098934 AK304366 AK025439 BT007283 CR457342 BC007826 | |
| CCDS | CCDS31915.1 CCDS9221.1 | |
| RefSeq | NP_001243787.1 NP_079402.2 NP_919247.1 | |
| UniGene | Hs.292804 | |
| ProteinModelPortal | Q969K3 | |
| SMR | Q969K3 | |
| BioGrid | 123169 | |
| IntAct | Q969K3 | |
| STRING | 9606.ENSP00000376258 | |
| iPTMnet | Q969K3 | |
| PhosphoSite | Q969K3 | |
| BioMuta | RNF34 | |
| DMDM | 74760679 | |
| EPD | Q969K3 | |
| MaxQB | Q969K3 | |
| PaxDb | Q969K3 | |
| PRIDE | Q969K3 | |
| DNASU | 80196 | |
| Ensembl | ENST00000361234 ENST00000392465 | |
| GeneID | 80196 | |
| KEGG | hsa:80196 | |
| UCSC | uc001uak.3 | |
| CTD | 80196 | |
| GeneCards | RNF34 | |
| HGNC | HGNC:17297 | |
| MIM | 608299 | |
| neXtProt | NX_Q969K3 | |
| PharmGKB | PA34436 | |
| eggNOG | ENOG410IMEF ENOG410Y1GP | |
| GeneTree | ENSGT00390000012719 | |
| HOGENOM | HOG000068080 | |
| HOVERGEN | HBG055079 | |
| InParanoid | Q969K3 | |
| PhylomeDB | Q969K3 | |
| TreeFam | TF325195 | |
| Reactome | R-HSA-983168 | |
| UniPathway | UPA00143 | |
| ChiTaRS | RNF34 | |
| GeneWiki | RNF34 | |
| GenomeRNAi | 80196 | |
| NextBio | 70550 | |
| PRO | PR:Q969K3 | |
| Proteomes | UP000005640 | |
| Bgee | Q969K3 | |
| CleanEx | HS_RNF34 | |
| ExpressionAtlas | Q969K3 | |
| Genevisible | Q969K3 | |
| GO | GO:0005737 GO:0005829 GO:0012505 GO:0016607 GO:0005634 GO:0005886 GO:0016874 GO:0002039 GO:1901981 GO:0061630 GO:0031625 GO:0008270 GO:0070417 GO:2001271 GO:1902042 GO:1901797 GO:0035872 GO:0043161 GO:0070936 GO:0016567 GO:0042787 GO:2000374 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR011011 IPR001841 IPR013083 | |
| SMART | SM00184 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000374 |
regulation of oxygen metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035872 |
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901797 |
negative regulation of signal transduction by p53 class mediator |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001271 |
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1901981 |
phosphatidylinositol phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6AYH3 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6AYH3 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000374 |
regulation of oxygen metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KR6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070417 |
cellular response to cold |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KR6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KR6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KR6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6804441 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012505 |
endomembrane system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 McDonald, ER 3rd & El-Deiry, WS (2004) Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 101 6170-5 PubMed GONUTS page
- ↑ 2.0 2.1 Sasaki, S et al. (2002) Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. Oncogene 21 5024-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Wei, P et al. (2012) RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Mol. Cell. Biol. 32 266-75 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Yang, W et al. (2007) CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. J. Biol. Chem. 282 3273-81 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Zhang, R et al. (2014) The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway. Cell. Physiol. Biochem. 33 1954-62 PubMed GONUTS page
- ↑ 6.0 6.1 Yang, W et al. (2008) CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. Cell Cycle 7 670-82 PubMed GONUTS page
c
n
- GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- GO:1901797 ! negative regulation of signal transduction by p53 class mediator
- GO:0016604 ! nuclear body
- GO:0016607 ! nuclear speck
- GO:0005654 ! nucleoplasm
- GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- GO:0005634 ! nucleus
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