HUMAN:CUL3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CUL3 (synonyms: KIAA0617)
Protein Name(s)	Cullin-3 CUL-3
External Links
UniProt	Q13618
EMBL	AF064087 AB014517 AF062537 AY337761 AK291151 AC073052 AC092679 CH471063 BC031844 BC039598 BC092409 U58089 AF052147
CCDS	CCDS2462.1 CCDS58751.1
RefSeq	NP_001244126.1 NP_001244127.1 NP_003581.1
UniGene	Hs.372286
PDB	4AP2 4APF 4EOZ 4HXI
PDBsum	4AP2 4APF 4EOZ 4HXI
ProteinModelPortal	Q13618
SMR	Q13618
BioGrid	114030
DIP	DIP-31611N
IntAct	Q13618
MINT	MINT-3028280
STRING	9606.ENSP00000264414
PhosphoSite	Q13618
DMDM	12643396
MaxQB	Q13618
PaxDb	Q13618
PRIDE	Q13618
Ensembl	ENST00000264414 ENST00000344951 ENST00000409096 ENST00000409777
GeneID	8452
KEGG	hsa:8452
UCSC	uc002vny.3 uc010zls.2
CTD	8452
GeneCards	GC02M225298
HGNC	HGNC:2553
HPA	CAB002678
MIM	603136 614496
neXtProt	NX_Q13618
Orphanet	300530
PharmGKB	PA27049
eggNOG	COG5647
GeneTree	ENSGT00760000119212
HOVERGEN	HBG003619
InParanoid	Q13618
KO	K03869
OMA	AMGKATQ
OrthoDB	EOG7C5M7H
PhylomeDB	Q13618
TreeFam	TF105858
Reactome	REACT_200841 REACT_75842
SignaLink	Q13618
UniPathway	UPA00143
ChiTaRS	CUL3
GeneWiki	CUL3
GenomeRNAi	8452
NextBio	31630
PRO	PR:Q13618
Proteomes	UP000005640
Bgee	Q13618
CleanEx	HS_CUL3
ExpressionAtlas	Q13618
Genevestigator	Q13618
GO	GO:0031463 GO:0070062 GO:0000139 GO:0016020 GO:0005634 GO:0005827 GO:0031208 GO:0007050 GO:0016477 GO:0048208 GO:0008054 GO:0040016 GO:0006888 GO:0000082 GO:0007369 GO:0007229 GO:0097193 GO:0007080 GO:0035024 GO:0008284 GO:0032467 GO:0045842 GO:0043161 GO:0006513 GO:0000209 GO:0016567 GO:0017145 GO:0043149 GO:0001831 GO:0016055
Gene3D	1.10.10.10
InterPro	IPR016157 IPR016158 IPR001373 IPR019559 IPR016159 IPR011991
Pfam	PF00888 PF10557
SMART	SM00182 SM00884
SUPFAM	SSF74788 SSF75632
PROSITE	PS01256 PS50069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016567	protein ubiquitination	PMID:24518042^[1]	ECO:0000314			P		This paper discusses the effect of Cullin-3 and its role in ubiquitination which provides necessary information for this annotation.	complete CACAO 10688
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:24844779^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:24844779^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:27561354^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	PMID:27561354^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:26399832^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:24768539^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28395323^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	PMID:28395323^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048208	COPII vesicle coating	PMID:22358839^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:19261606^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:19782033^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:20389280^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:19782033^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040016	embryonic cleavage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLV5	P		Seeded From UniProt	complete
involved_in	GO:0035024	negative regulation of Rho protein signal transduction	PMID:19782033^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:19261606^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:23576762^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:23453970^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:22578813^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:19158078^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:23455478^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:19261606^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:22358839^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:15983046^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:19782033^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:19995937^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:17543862^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031463	Cul3-RING ubiquitin ligase complex	PMID:20389280^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031208	POZ domain binding	PMID:19261606^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0017145	stem cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLV5	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:19782033^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:19995937^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:17543862^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:20389280^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:19782033^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLV5	P		Seeded From UniProt	complete
involved_in	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	PMID:22358839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	PMID:22358839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005827	polar microtubule	PMID:19995937^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	PMID:19261606^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	PMID:15983046^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	PMID:19782033^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	PMID:20389280^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007080	mitotic metaphase plate congression	PMID:19995937^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007080	mitotic metaphase plate congression	PMID:17543862^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:19261606^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	PMID:17543862^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 SGD:S000002290	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261268 MGI:MGI:1347360 MGI:MGI:1349658 MGI:MGI:1914487 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q13618 UniProtKB:Q13619 UniProtKB:Q5AJB7 WB:WBGene00000837 WB:WBGene00000839	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 FB:FBgn0032956 FB:FBgn0033260 FB:FBgn0039632 FB:FBgn0261268 PANTHER:PTN000231993 UniProtKB:Q13617 UniProtKB:Q93034	F		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 UniProtKB:Q13616 UniProtKB:Q57UJ3	C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q5AJB7	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 dictyBase:DDB_G0291972	C		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914487 PANTHER:PTN000231993 SGD:S000002290 SGD:S000003235 UniProtKB:Q13618 UniProtKB:Q57UJ3	P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	PMID:10500095^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:25401743^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	PMID:25401743^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P46531	F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048208	C		Seeded From UniProt	complete
involved_in	GO:0072576	liver morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	F		Seeded From UniProt	complete
involved_in	GO:0044346	fibroblast apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	F		Seeded From UniProt	complete
involved_in	GO:0040016	embryonic cleavage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	F		Seeded From UniProt	complete
involved_in	GO:0017145	stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	C		Seeded From UniProt	complete
involved_in	GO:0001831	trophectodermal cellular morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV5 ensembl:ENSMUSP00000130738	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	P		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016157	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	F		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:8681378^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:9733711^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:8681378^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641258	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8956040 Reactome:R-HSA-8955289 Reactome:R-HSA-8955241 Reactome:R-HSA-5658424 Reactome:R-HSA-1504213 Reactome:R-HSA-1504193 Reactome:R-HSA-1504190	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5635856 Reactome:R-HSA-5635855 Reactome:R-HSA-5635854	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0931	P		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0282 UniProtKB-SubCell:SL-0117	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Andérica-Romero, AC et al. (2014) Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis. Cell. Signal. 26 1166-72 PubMed GONUTS page
↑ ^2.0 ^2.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page
↑ ^3.0 ^3.1 Ferretti, LP et al. (2016) Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nat Commun 7 12628 PubMed GONUTS page
↑ Werner, A et al. (2015) Cell-fate determination by ubiquitin-dependent regulation of translation. Nature 525 523-7 PubMed GONUTS page
↑ Yuan, WC et al. (2014) K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol. Cell 54 586-600 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 Jumeau, F et al. (2017) Defining the human sperm microtubulome: an integrated genomics approach. Biol. Reprod. 96 93-106 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Jin, L et al. (2012) Ubiquitin-dependent regulation of COPII coat size and function. Nature 482 495-500 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Cummings, CM et al. (2009) The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J. Biol. Chem. 284 11663-75 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Chen, Y et al. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell 35 841-55 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Lee, YR et al. (2010) The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J. 29 1748-61 PubMed GONUTS page
↑ Shibata, S et al. (2013) Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc. Natl. Acad. Sci. U.S.A. 110 7838-43 PubMed GONUTS page
↑ Wakabayashi, M et al. (2013) Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep 3 858-68 PubMed GONUTS page
↑ Yanagiya, A et al. (2012) Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol. Cell 46 847-58 PubMed GONUTS page
↑ Nam, S et al. (2009) Control of rapsyn stability by the CUL-3-containing E3 ligase complex. J. Biol. Chem. 284 8195-206 PubMed GONUTS page
↑ Beck, J et al. (2013) Ubiquitylation-dependent localization of PLK1 in mitosis. Nat. Cell Biol. 15 430-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Zhang, DD et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280 30091-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Maerki, S et al. (2009) The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J. Cell Biol. 187 791-800 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Sumara, I et al. (2007) A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev. Cell 12 887-900 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Singer, JD et al. (1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13 2375-87 PubMed GONUTS page
↑ ^23.0 ^23.1 Ren, K et al. (2014) KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. PLoS ONE 9 e112275 PubMed GONUTS page
↑ ^24.0 ^24.1 Kipreos, ET et al. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85 829-39 PubMed GONUTS page
↑ Du, M et al. (1998) Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family. J. Biol. Chem. 273 24289-92 PubMed GONUTS page

[PMID:24518042-1] Andérica-Romero, AC et al. (2014) Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis. Cell. Signal. 26 1166-72 PubMed GONUTS page

[PMID:24844779-2] 2.0 ^2.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page

[PMID:27561354-3] 3.0 ^3.1 Ferretti, LP et al. (2016) Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nat Commun 7 12628 PubMed GONUTS page

[PMID:26399832-4] Werner, A et al. (2015) Cell-fate determination by ubiquitin-dependent regulation of translation. Nature 525 523-7 PubMed GONUTS page

[PMID:24768539-5] Yuan, WC et al. (2014) K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol. Cell 54 586-600 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:28395323-8] 8.0 ^8.1 Jumeau, F et al. (2017) Defining the human sperm microtubulome: an integrated genomics approach. Biol. Reprod. 96 93-106 PubMed GONUTS page

[PMID:22358839-9] 9.0 ^9.1 ^9.2 ^9.3 Jin, L et al. (2012) Ubiquitin-dependent regulation of COPII coat size and function. Nature 482 495-500 PubMed GONUTS page

[PMID:19261606-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Cummings, CM et al. (2009) The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J. Biol. Chem. 284 11663-75 PubMed GONUTS page

[PMID:19782033-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Chen, Y et al. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell 35 841-55 PubMed GONUTS page

[PMID:20389280-12] 12.0 ^12.1 ^12.2 ^12.3 Lee, YR et al. (2010) The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J. 29 1748-61 PubMed GONUTS page

[PMID:23576762-13] Shibata, S et al. (2013) Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc. Natl. Acad. Sci. U.S.A. 110 7838-43 PubMed GONUTS page

[PMID:23453970-14] Wakabayashi, M et al. (2013) Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep 3 858-68 PubMed GONUTS page

[PMID:22578813-15] Yanagiya, A et al. (2012) Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol. Cell 46 847-58 PubMed GONUTS page

[PMID:19158078-16] Nam, S et al. (2009) Control of rapsyn stability by the CUL-3-containing E3 ligase complex. J. Biol. Chem. 284 8195-206 PubMed GONUTS page

[PMID:23455478-17] Beck, J et al. (2013) Ubiquitylation-dependent localization of PLK1 in mitosis. Nat. Cell Biol. 15 430-9 PubMed GONUTS page

[PMID:15983046-18] 18.0 ^18.1 Zhang, DD et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280 30091-9 PubMed GONUTS page

[PMID:19995937-19] 19.0 ^19.1 ^19.2 ^19.3 Maerki, S et al. (2009) The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J. Cell Biol. 187 791-800 PubMed GONUTS page

[PMID:17543862-20] 20.0 ^20.1 ^20.2 ^20.3 Sumara, I et al. (2007) A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev. Cell 12 887-900 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10500095-22] Singer, JD et al. (1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13 2375-87 PubMed GONUTS page

[PMID:25401743-23] 23.0 ^23.1 Ren, K et al. (2014) KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. PLoS ONE 9 e112275 PubMed GONUTS page

[PMID:8681378-24] 24.0 ^24.1 Kipreos, ET et al. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85 829-39 PubMed GONUTS page

[PMID:9733711-25] Du, M et al. (1998) Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family. J. Biol. Chem. 273 24289-92 PubMed GONUTS page

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HUMAN:CUL3

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