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Kipreos, ET, Lander, LE, Wing, JP, He, WW and Hedgecock, EM (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85:829-39
The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.
Amino Acid Sequence; Animals; Apoptosis/physiology; Base Sequence; Caenorhabditis elegans/chemistry; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Cell Cycle/physiology; Cell Cycle Proteins; Chromosome Mapping; Cloning, Molecular; Cullin Proteins; DNA, Complementary/genetics; Genes, Helminth/genetics; Germ Layers; Helminth Proteins/chemistry; Helminth Proteins/genetics; Helminth Proteins/physiology; Humans; Larva; Molecular Sequence Data; Mutation; RNA, Helminth/genetics; RNA, Messenger/genetics; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Yeasts
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