HUMAN:TOPRS

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TOPORS (synonyms: LUN, TP53BPL)
Protein Name(s)	E3 ubiquitin-protein ligase Topors SUMO1-protein E3 ligase Topors Topoisomerase I-binding RING finger protein Topoisomerase I-binding arginine/serine-rich protein Tumor suppressor p53-binding protein 3 p53-binding protein 3 p53BP3
External Links
UniProt	Q9NS56
EMBL	AF098300 AB045732 AB045733 AL353671 AL353671 BC060884 U82939
CCDS	CCDS56566.1 CCDS6527.1
RefSeq	NP_001182551.1 NP_005793.2
UniGene	Hs.589962
ProteinModelPortal	Q9NS56
SMR	Q9NS56
BioGrid	115505
IntAct	Q9NS56
MINT	MINT-94004
STRING	9606.ENSP00000353735
iPTMnet	Q9NS56
PhosphoSite	Q9NS56
BioMuta	TOPORS
DMDM	74752935
MaxQB	Q9NS56
PaxDb	Q9NS56
PRIDE	Q9NS56
Ensembl	ENST00000360538 ENST00000379858
GeneID	10210
KEGG	hsa:10210
UCSC	uc003zrb.3 uc003zrc.3
CTD	10210
GeneCards	TOPORS
GeneReviews	TOPORS
HGNC	HGNC:21653
HPA	HPA065661
MalaCards	TOPORS
MIM	609507 609923
neXtProt	NX_Q9NS56
Orphanet	791
PharmGKB	PA134979531
eggNOG	KOG4430 ENOG410XQZR
GeneTree	ENSGT00530000064170
HOGENOM	HOG000231723
HOVERGEN	HBG080410
InParanoid	Q9NS56
KO	K10631
OMA	DIINFRR
OrthoDB	EOG722J8G
PhylomeDB	Q9NS56
TreeFam	TF339497
ChiTaRS	TOPORS
GeneWiki	TOPORS
GenomeRNAi	10210
NextBio	38656
PRO	PR:Q9NS56
Proteomes	UP000005640
Bgee	Q9NS56
CleanEx	HS_TOPORS
Genevisible	Q9NS56
GO	GO:0005814 GO:0036064 GO:0000930 GO:0030496 GO:0016607 GO:0005634 GO:0032391 GO:0016605 GO:0000922 GO:0000151 GO:0003823 GO:0003677 GO:0044547 GO:0016874 GO:0019789 GO:0061630 GO:0004842 GO:0008270 GO:0006974 GO:0008630 GO:0042771 GO:0051457 GO:0043066 GO:0035845 GO:0045893 GO:0051443 GO:0043161 GO:0070936 GO:0034504 GO:0006513 GO:0000209 GO:0016925 GO:0042127 GO:0010842 GO:0046549 GO:0046548 GO:0006351 GO:0006511
Gene3D	3.30.40.10
InterPro	IPR001841 IPR013083 IPR017907
SMART	SM00184
PROSITE	PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000209	protein polyubiquitination	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005814	centriole	PMID:26872363^[2]	ECO:0000314			C		S3 Fig. N-TOPORS localises to the nucleus and centrioles. Human (h)TERT-RPE1 cells were either co-transfected with V5-tagged N-TOPORS and FLAG-tagged full-length TOPORS (top panel), or with V5-tagged N-TOPORS only (middle and bottom panels). The V5-tagged artificial N-TOPORS fragment co-localised with FLAG-tagged full-length TOPORS (top panel) and endogenous TOPORS (middle panel) at nuclei of hTERT-RPE1 cells and it co-localised with pericentrin at the centrioles.	complete CACAO 11369
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046549	retinal cone cell development	PMID:21159800^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5BLE0	P		Seeded From UniProt	complete
involved_in	GO:0046548	retinal rod cell development	PMID:21159800^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5BLE0	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21159800^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5BLE0	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035845	photoreceptor cell outer segment organization	PMID:21159800^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5BLE0	P		Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000080)\|exists_during:(GO:0000084)\|exists_during:(GO:0000085)	Seeded From UniProt	complete
involved_in	GO:0010842	retina layer formation	PMID:21159800^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5BLE0	P		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000080)\|exists_during:(GO:0000084)\|exists_during:(GO:0000085)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P04637)	Seeded From UniProt	complete
part_of	GO:0000930	gamma-tubulin complex	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000080)\|exists_during:(GO:0000084)\|exists_during:(GO:0000085)	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:21159800^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000278)	Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:15247280^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051457	maintenance of protein location in nucleus	PMID:14516784^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044547	DNA topoisomerase binding	PMID:10352183^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11387	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:18077445^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:20188669^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	PMID:19473992^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	PMID:17803295^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	PMID:20188669^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	PMID:17803295^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:14516784^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:20188669^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:20188669^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15735665^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:19473992^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:10352183^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18077445^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19473992^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:18077445^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003823	antigen binding	PMID:10415337^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11278651^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	PMID:17803295^[9]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	C		Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Z37 ensembl:ENSMUSP00000046843	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:21159800^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	exists_during:(GO:0051326)	Seeded From UniProt	complete
colocalizes_with	GO:0005868	cytoplasmic dynein complex	PMID:21159800^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4755478 Reactome:R-HSA-4551683 Reactome:R-HSA-4085994	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Rajendra, R et al. (2004) Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J. Biol. Chem. 279 36440-4 PubMed GONUTS page
↑ Czub, B et al. (2016) TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene. PLoS ONE 11 e0148678 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Chakarova, CF et al. (2011) TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein. Hum. Mol. Genet. 20 975-87 PubMed GONUTS page
↑ ^4.0 ^4.1 Weger, S et al. (2003) The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Exp. Cell Res. 290 13-27 PubMed GONUTS page
↑ ^5.0 ^5.1 Haluska, P Jr et al. (1999) Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Nucleic Acids Res. 27 2538-44 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Guan, B et al. (2008) Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. J. Biol. Chem. 283 4834-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Renner, F et al. (2010) SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol. Cell 37 503-15 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yang, X et al. (2009) Plk1-mediated phosphorylation of Topors regulates p53 stability. J. Biol. Chem. 284 18588-92 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Pungaliya, P et al. (2007) TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. J. Proteome Res. 6 3918-23 PubMed GONUTS page
↑ Lin, L et al. (2005) topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 24 3385-96 PubMed GONUTS page
↑ Zhou, R et al. (1999) Identification of a novel gene encoding a p53-associated protein. Gene 235 93-101 PubMed GONUTS page
↑ Chu, D et al. (2001) Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence. J. Biol. Chem. 276 14004-13 PubMed GONUTS page

[PMID:15247280-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Rajendra, R et al. (2004) Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J. Biol. Chem. 279 36440-4 PubMed GONUTS page

[PMID:26872363-2] Czub, B et al. (2016) TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene. PLoS ONE 11 e0148678 PubMed GONUTS page

[PMID:21159800-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Chakarova, CF et al. (2011) TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein. Hum. Mol. Genet. 20 975-87 PubMed GONUTS page

[PMID:14516784-4] 4.0 ^4.1 Weger, S et al. (2003) The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Exp. Cell Res. 290 13-27 PubMed GONUTS page

[PMID:10352183-5] 5.0 ^5.1 Haluska, P Jr et al. (1999) Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Nucleic Acids Res. 27 2538-44 PubMed GONUTS page

[PMID:18077445-6] 6.0 ^6.1 ^6.2 Guan, B et al. (2008) Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. J. Biol. Chem. 283 4834-40 PubMed GONUTS page

[PMID:20188669-7] 7.0 ^7.1 ^7.2 ^7.3 Renner, F et al. (2010) SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol. Cell 37 503-15 PubMed GONUTS page

[PMID:19473992-8] 8.0 ^8.1 ^8.2 Yang, X et al. (2009) Plk1-mediated phosphorylation of Topors regulates p53 stability. J. Biol. Chem. 284 18588-92 PubMed GONUTS page

[PMID:17803295-9] 9.0 ^9.1 ^9.2 Pungaliya, P et al. (2007) TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. J. Proteome Res. 6 3918-23 PubMed GONUTS page

[PMID:15735665-10] Lin, L et al. (2005) topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 24 3385-96 PubMed GONUTS page

[PMID:10415337-11] Zhou, R et al. (1999) Identification of a novel gene encoding a p53-associated protein. Gene 235 93-101 PubMed GONUTS page

[PMID:11278651-12] Chu, D et al. (2001) Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence. J. Biol. Chem. 276 14004-13 PubMed GONUTS page

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HUMAN:TOPRS

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