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HUMAN:TRI37

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRIM37 (ECO:0000312 with HGNC:HGNC:7523)
Protein Name(s) E3 ubiquitin-protein ligase TRIM37 (ECO:0000305)

Mulibrey nanism protein (ECO:0000303 with PMID:10888877[1]) RING-type E3 ubiquitin transferase TRIM37 (ECO:0000305) Tripartite motif-containing protein 37 (ECO:0000305)

External Links
UniProt O94972
EMBL AF213365
AB020705
AK289674
AK294850
AK292459
BX537955
AC005207
AC036154
AC099850
AC100832
CH471109
CH471109
BC036012
CCDS CCDS32694.1
CCDS45746.1
CCDS82174.1
RefSeq NP_001005207.1
NP_001307916.1
NP_001307919.1
NP_056109.1
UniGene Hs.579079
Hs.605697
PDB 3LRQ
PDBsum 3LRQ
ProteinModelPortal O94972
SMR O94972
BioGrid 110678
DIP DIP-34437N
IntAct O94972
MINT MINT-1433848
STRING 9606.ENSP00000262294
iPTMnet O94972
PhosphoSitePlus O94972
BioMuta TRIM37
MaxQB O94972
PaxDb O94972
PeptideAtlas O94972
PRIDE O94972
Ensembl ENST00000262294
ENST00000393065
ENST00000393066
GeneID 4591
KEGG hsa:4591
UCSC uc002iwy.5
uc010woc.3
CTD 4591
DisGeNET 4591
EuPathDB HostDB:ENSG00000108395.13
GeneCards TRIM37
H-InvDB HIX0014039
HGNC HGNC:7523
HPA HPA021911
MalaCards TRIM37
MIM 253250
605073
neXtProt NX_O94972
OpenTargets ENSG00000108395
Orphanet 2576
PharmGKB PA35497
eggNOG ENOG410ITG1
ENOG410YSD5
GeneTree ENSGT00410000025800
HOGENOM HOG000013010
HOVERGEN HBG057591
InParanoid O94972
KO K10608
OMA TQMAEVR
OrthoDB EOG091G01C1
PhylomeDB O94972
TreeFam TF351092
Reactome [www.reactome.org/content/detail/R-HSA-983168 R-HSA-983168]
SignaLink O94972
UniPathway UPA00143
ChiTaRS TRIM37
EvolutionaryTrace O94972
GeneWiki TRIM37
GenomeRNAi 4591
PRO PR:O94972
Proteomes UP000005640
Bgee ENSG00000108395
CleanEx HS_TRIM37
ExpressionAtlas O94972
Genevisible O94972
GO GO:0016235
GO:0005737
GO:0005829
GO:0048471
GO:0005777
GO:0003682
GO:0042803
GO:0005164
GO:0061630
GO:0031625
GO:0004842
GO:0008270
GO:0070842
GO:0035518
GO:0036353
GO:0046600
GO:0032088
GO:0000122
GO:0051092
GO:0051091
GO:0051865
GO:0006351
CDD cd00021
Gene3D 2.60.210.10
3.30.40.10
InterPro IPR003649
IPR002083
IPR008974
IPR000315
IPR001841
IPR013083
Pfam PF00917
PF00643
SMART SM00502
SM00336
SM00061
SUPFAM SSF49599
PROSITE PS50144
PS50119
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

colocalizes_with

GO:0035098

ESC/E(Z) complex

PMID:25470042[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:25470042[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:25470042[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036353

histone H2A-K119 monoubiquitination

PMID:25470042[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035518

histone H2A monoubiquitination

PMID:25470042[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:23077300[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:23077300[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P05412)

Seeded From UniProt

complete

involved_in

GO:0070842

aggresome assembly

PMID:15885686[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

PMID:15885686[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046600

negative regulation of centriole replication

PMID:23769972[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11279055[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:11279055[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13077

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q12933

F

Seeded From UniProt

complete

part_of

GO:0016235

aggresome

PMID:15885686[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11279055[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

PMID:11938494[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23769972[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P36941

F

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P20333

F

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P08138

F

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:11279055[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P25942

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:15885686[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0036353

histone H2A-K119 monoubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6PCX9
ensembl:ENSMUSP00000049057

P

Seeded From UniProt

complete

involved_in

GO:0035518

histone H2A monoubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6PCX9
ensembl:ENSMUSP00000049057

P

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6PCX9
ensembl:ENSMUSP00000049057

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000315

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037299

P

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0576
UniProtKB-SubCell:SL-0204

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Avela, K et al. (2000) Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Nat. Genet. 25 298-301 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Bhatnagar, S et al. (2014) TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature 516 116-20 PubMed GONUTS page
  3. ↑ 3.0 3.1 Uchil, PD et al. (2013) TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J. Virol. 87 257-72 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Kallijärvi, J et al. (2005) TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. Exp. Cell Res. 308 146-55 PubMed GONUTS page
  5. ↑ 5.0 5.1 Balestra, FR et al. (2013) Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev. Cell 25 555-71 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page
  7. ↑ Kallijärvi, J et al. (2002) The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. Am. J. Hum. Genet. 70 1215-28 PubMed GONUTS page
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