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Category:GO:0035098 ! ESC/E(Z) complex
name: ESC/E(Z) complex
namespace: cellular_component
def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:krc, GOC:sp, PMID:12408863, PMID:12408864, PMID:17107999, PMID:20064375, PMID:31123059, PMID:33232890]
synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT []
synonym: "polycomb repressive complex 2" EXACT []
synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375]
is_a: GO:0031519 ! PcG protein complex
is_a: GO:0035097 ! histone methyltransferase complex
AmiGO
<GOterm>GO:0035098</GOterm>
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