HUMAN:RBBP4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RBBP4 (synonyms: RBAP48)
Protein Name(s)	Histone-binding protein RBBP4 Chromatin assembly factor 1 subunit C CAF-1 subunit C Chromatin assembly factor I p48 subunit CAF-I 48 kDa subunit CAF-I p48 Nucleosome-remodeling factor subunit RBAP48 Retinoblastoma-binding protein 4 RBBP-4 Retinoblastoma-binding protein p48
External Links
UniProt	Q09028
EMBL	X74262 X71810 BT007309 AK299251 AK312571 AK222779 AC114489 CH471059 CH471059 BC003092 BC015123 BC053904 BC075836
CCDS	CCDS366.1 CCDS44105.1 CCDS44106.1
PIR	S36112
RefSeq	NP_001128727.1 NP_001128728.1 NP_005601.1
UniGene	Hs.16003
PDB	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY
PDBsum	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY
ProteinModelPortal	Q09028
SMR	Q09028
BioGrid	111863
DIP	DIP-33495N
IntAct	Q09028
MINT	MINT-90543
STRING	9606.ENSP00000362592
ChEMBL	CHEMBL3301388
iPTMnet	Q09028
PhosphoSitePlus	Q09028
SwissPalm	Q09028
BioMuta	RBBP4
DMDM	1172846
EPD	Q09028
MaxQB	Q09028
PaxDb	Q09028
PeptideAtlas	Q09028
PRIDE	Q09028
DNASU	5928
Ensembl	ENST00000373485 ENST00000373493 ENST00000414241 ENST00000458695
GeneID	5928
KEGG	hsa:5928
UCSC	uc001bvr.3
CTD	5928
DisGeNET	5928
GeneCards	RBBP4
HGNC	HGNC:9887
HPA	CAB006264 HPA060710 HPA060724
MIM	602923
neXtProt	NX_Q09028
OpenTargets	ENSG00000162521
PharmGKB	PA34251
eggNOG	KOG0264 ENOG410XNU9
GeneTree	ENSGT00570000079069
HOVERGEN	HBG053236
InParanoid	Q09028
KO	K10752
OMA	MLMVWDT
OrthoDB	EOG091G0A20
PhylomeDB	Q09028
TreeFam	TF106485
Reactome	[www.reactome.org/content/detail/R-HSA-1538133 R-HSA-1538133] [www.reactome.org/content/detail/R-HSA-156711 R-HSA-156711] [www.reactome.org/content/detail/R-HSA-212300 R-HSA-212300] [www.reactome.org/content/detail/R-HSA-2559580 R-HSA-2559580] [www.reactome.org/content/detail/R-HSA-3214815 R-HSA-3214815] [www.reactome.org/content/detail/R-HSA-3214841 R-HSA-3214841] [www.reactome.org/content/detail/R-HSA-427389 R-HSA-427389] [www.reactome.org/content/detail/R-HSA-5617472 R-HSA-5617472] [www.reactome.org/content/detail/R-HSA-606279 R-HSA-606279] [www.reactome.org/content/detail/R-HSA-6804758 R-HSA-6804758] [www.reactome.org/content/detail/R-HSA-73762 R-HSA-73762]
SignaLink	Q09028
SIGNOR	Q09028
ChiTaRS	RBBP4
EvolutionaryTrace	Q09028
GeneWiki	RBBP4
GenomeRNAi	5928
PRO	PR:Q09028
Proteomes	UP000005640
Bgee	ENSG00000162521
CleanEx	HS_RBBP4
ExpressionAtlas	Q09028
Genevisible	Q09028
GO	GO:0033186 GO:0005829 GO:0035098 GO:0000790 GO:0005654 GO:0005634 GO:0016581 GO:0016589 GO:0043234 GO:0016580 GO:0042393 GO:0004407 GO:0042826 GO:0043044 GO:0007049 GO:0034080 GO:0031497 GO:0006338 GO:0006260 GO:0006335 GO:0006336 GO:0008285 GO:0045814 GO:0051726 GO:1901796 GO:0006355 GO:0006351
Gene3D	2.130.10.10
InterPro	IPR020472 IPR022052 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF12265 PF00400
PRINTS	PR00320
SMART	SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016581	NuRD complex	PMID:22926524^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:14718166^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0006336)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:14718166^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0006335)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0031492	nucleosomal DNA binding	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006336	DNA replication-independent nucleosome assembly	PMID:14718166^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006335	DNA replication-dependent nucleosome assembly	PMID:14718166^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:22720776^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:16217013^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:14718166^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17827154^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17827154^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:17827154^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	PMID:17827154^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0008094	DNA-dependent ATPase activity	PMID:14609955^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:14609955^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14609955^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:23273982^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:23104054^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:20075857^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033186	CAF-1 complex	PMID:8858152^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031497	chromatin assembly	PMID:8858152^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016589	NURF complex	PMID:20850016^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:19644445^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:8350924^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	Reactome:R-HSA-156711	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	Reactome:R-HSA-212300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034080	CENP-A containing nucleosome assembly	Reactome:R-HSA-606279	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9007640 Reactome:R-HSA-8964498 Reactome:R-HSA-8964492 Reactome:R-HSA-8964482 Reactome:R-HSA-8964475 Reactome:R-HSA-8964471 Reactome:R-HSA-8964465 Reactome:R-HSA-8954110 Reactome:R-HSA-8943780 Reactome:R-HSA-6805650 Reactome:R-HSA-606326 Reactome:R-HSA-606289 Reactome:R-HSA-606287 Reactome:R-HSA-5638332 Reactome:R-HSA-4088309 Reactome:R-HSA-4088307 Reactome:R-HSA-4088306 Reactome:R-HSA-3769447 Reactome:R-HSA-3240957 Reactome:R-HSA-3240295 Reactome:R-HSA-212269 Reactome:R-HSA-212263 Reactome:R-HSA-212252 Reactome:R-HSA-212222 Reactome:R-HSA-1362270 Reactome:R-HSA-1362261	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tagami, H et al. (2004) Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116 51-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page
↑ Todd, MA & Picketts, DJ (2012) PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J. Proteome Res. 11 4326-37 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Barak, O et al. (2003) Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. 22 6089-100 PubMed GONUTS page
↑ Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page
↑ Ballaré, C et al. (2012) Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat. Struct. Mol. Biol. 19 1257-65 PubMed GONUTS page
↑ Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page
↑ ^10.0 ^10.1 Verreault, A et al. (1996) Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87 95-104 PubMed GONUTS page
↑ Vermeulen, M et al. (2010) Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142 967-80 PubMed GONUTS page
↑ Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page
↑ Qian, YW et al. (1993) A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364 648-52 PubMed GONUTS page

[PMID:22926524-1] Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page

[PMID:14718166-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tagami, H et al. (2004) Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116 51-61 PubMed GONUTS page

[PMID:16217013-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page

[PMID:22720776-4] Todd, MA & Picketts, DJ (2012) PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J. Proteome Res. 11 4326-37 PubMed GONUTS page

[PMID:17827154-5] 5.0 ^5.1 ^5.2 ^5.3 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page

[PMID:14609955-6] 6.0 ^6.1 ^6.2 Barak, O et al. (2003) Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. 22 6089-100 PubMed GONUTS page

[PMID:23273982-7] Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page

[PMID:23104054-8] Ballaré, C et al. (2012) Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat. Struct. Mol. Biol. 19 1257-65 PubMed GONUTS page

[PMID:20075857-9] Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page

[PMID:8858152-10] 10.0 ^10.1 Verreault, A et al. (1996) Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87 95-104 PubMed GONUTS page

[PMID:20850016-11] Vermeulen, M et al. (2010) Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142 967-80 PubMed GONUTS page

[PMID:19644445-12] Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page

[PMID:8350924-13] Qian, YW et al. (1993) A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364 648-52 PubMed GONUTS page

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HUMAN:RBBP4

Contents

Annotations

Notes

References

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