GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:RBBP4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBBP4 (synonyms: RBAP48)
Protein Name(s) Histone-binding protein RBBP4

Chromatin assembly factor 1 subunit C CAF-1 subunit C Chromatin assembly factor I p48 subunit CAF-I 48 kDa subunit CAF-I p48 Nucleosome-remodeling factor subunit RBAP48 Retinoblastoma-binding protein 4 RBBP-4 Retinoblastoma-binding protein p48

External Links
UniProt Q09028
EMBL X74262
X71810
BT007309
AK299251
AK312571
AK222779
AC114489
CH471059
CH471059
BC003092
BC015123
BC053904
BC075836
CCDS CCDS366.1
CCDS44105.1
CCDS44106.1
PIR S36112
RefSeq NP_001128727.1
NP_001128728.1
NP_005601.1
UniGene Hs.16003
PDB 2XU7
3GFC
4PBY
4PBZ
4PC0
4R7A
5FXY
PDBsum 2XU7
3GFC
4PBY
4PBZ
4PC0
4R7A
5FXY
ProteinModelPortal Q09028
SMR Q09028
BioGrid 111863
DIP DIP-33495N
IntAct Q09028
MINT MINT-90543
STRING 9606.ENSP00000362592
ChEMBL CHEMBL3301388
iPTMnet Q09028
PhosphoSitePlus Q09028
SwissPalm Q09028
BioMuta RBBP4
DMDM 1172846
EPD Q09028
MaxQB Q09028
PaxDb Q09028
PeptideAtlas Q09028
PRIDE Q09028
DNASU 5928
Ensembl ENST00000373485
ENST00000373493
ENST00000414241
ENST00000458695
GeneID 5928
KEGG hsa:5928
UCSC uc001bvr.3
CTD 5928
DisGeNET 5928
GeneCards RBBP4
HGNC HGNC:9887
HPA CAB006264
HPA060710
HPA060724
MIM 602923
neXtProt NX_Q09028
OpenTargets ENSG00000162521
PharmGKB PA34251
eggNOG KOG0264
ENOG410XNU9
GeneTree ENSGT00570000079069
HOVERGEN HBG053236
InParanoid Q09028
KO K10752
OMA MLMVWDT
OrthoDB EOG091G0A20
PhylomeDB Q09028
TreeFam TF106485
Reactome [www.reactome.org/content/detail/R-HSA-1538133 R-HSA-1538133]
[www.reactome.org/content/detail/R-HSA-156711 R-HSA-156711]
[www.reactome.org/content/detail/R-HSA-212300 R-HSA-212300]
[www.reactome.org/content/detail/R-HSA-2559580 R-HSA-2559580]
[www.reactome.org/content/detail/R-HSA-3214815 R-HSA-3214815]
[www.reactome.org/content/detail/R-HSA-3214841 R-HSA-3214841]
[www.reactome.org/content/detail/R-HSA-427389 R-HSA-427389]
[www.reactome.org/content/detail/R-HSA-5617472 R-HSA-5617472]
[www.reactome.org/content/detail/R-HSA-606279 R-HSA-606279]
[www.reactome.org/content/detail/R-HSA-6804758 R-HSA-6804758]
[www.reactome.org/content/detail/R-HSA-73762 R-HSA-73762]
SignaLink Q09028
SIGNOR Q09028
ChiTaRS RBBP4
EvolutionaryTrace Q09028
GeneWiki RBBP4
GenomeRNAi 5928
PRO PR:Q09028
Proteomes UP000005640
Bgee ENSG00000162521
CleanEx HS_RBBP4
ExpressionAtlas Q09028
Genevisible Q09028
GO GO:0033186
GO:0005829
GO:0035098
GO:0000790
GO:0005654
GO:0005634
GO:0016581
GO:0016589
GO:0043234
GO:0016580
GO:0042393
GO:0004407
GO:0042826
GO:0043044
GO:0007049
GO:0034080
GO:0031497
GO:0006338
GO:0006260
GO:0006335
GO:0006336
GO:0008285
GO:0045814
GO:0051726
GO:1901796
GO:0006355
GO:0006351
Gene3D 2.130.10.10
InterPro IPR020472
IPR022052
IPR015943
IPR001680
IPR019775
IPR017986
Pfam PF12265
PF00400
PRINTS PR00320
SMART SM00320
SUPFAM SSF50978
PROSITE PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016581

NuRD complex

PMID:22926524[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:14718166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0006336)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:14718166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0006335)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043044

ATP-dependent chromatin remodeling

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0031492

nucleosomal DNA binding

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006336

DNA replication-independent nucleosome assembly

PMID:14718166[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006335

DNA replication-dependent nucleosome assembly

PMID:14718166[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:22720776[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:16217013[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:14718166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:17827154[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92769

F

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:17827154[5]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016581

NuRD complex

PMID:17827154[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016580

Sin3 complex

PMID:17827154[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0008094

DNA-dependent ATPase activity

PMID:14609955[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

PMID:14609955[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14609955[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035098

ESC/E(Z) complex

PMID:23273982[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035098

ESC/E(Z) complex

PMID:23104054[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035098

ESC/E(Z) complex

PMID:20075857[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0033186

CAF-1 complex

PMID:8858152[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031497

chromatin assembly

PMID:8858152[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016589

NURF complex

PMID:20850016[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016581

NuRD complex

PMID:19644445[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:8350924[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070317

negative regulation of G0 to G1 transition

Reactome:R-HSA-8953750

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

Reactome:R-HSA-156711

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045814

negative regulation of gene expression, epigenetic

Reactome:R-HSA-212300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034080

CENP-A containing nucleosome assembly

Reactome:R-HSA-606279

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9007640
Reactome:R-HSA-8964498
Reactome:R-HSA-8964492
Reactome:R-HSA-8964482
Reactome:R-HSA-8964475
Reactome:R-HSA-8964471
Reactome:R-HSA-8964465
Reactome:R-HSA-8954110
Reactome:R-HSA-8943780
Reactome:R-HSA-6805650
Reactome:R-HSA-606326
Reactome:R-HSA-606289
Reactome:R-HSA-606287
Reactome:R-HSA-5638332
Reactome:R-HSA-4088309
Reactome:R-HSA-4088307
Reactome:R-HSA-4088306
Reactome:R-HSA-3769447
Reactome:R-HSA-3240957
Reactome:R-HSA-3240295
Reactome:R-HSA-212269
Reactome:R-HSA-212263
Reactome:R-HSA-212252
Reactome:R-HSA-212222
Reactome:R-HSA-1362270
Reactome:R-HSA-1362261

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Tagami, H et al. (2004) Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116 51-61 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page
  4. Todd, MA & Picketts, DJ (2012) PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J. Proteome Res. 11 4326-37 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
  6. 6.0 6.1 6.2 Barak, O et al. (2003) Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. 22 6089-100 PubMed GONUTS page
  7. Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page
  8. Ballaré, C et al. (2012) Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat. Struct. Mol. Biol. 19 1257-65 PubMed GONUTS page
  9. Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page
  10. 10.0 10.1 Verreault, A et al. (1996) Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87 95-104 PubMed GONUTS page
  11. Vermeulen, M et al. (2010) Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142 967-80 PubMed GONUTS page
  12. Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page
  13. Qian, YW et al. (1993) A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364 648-52 PubMed GONUTS page