MOUSE:HDAC2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hdac2 (synonyms: Yy1bp)
Protein Name(s)	Histone deacetylase 2 HD2 YY1 transcription factor-binding protein
External Links
UniProt	P70288
EMBL	U31758 CH466540 BC138517
CCDS	CCDS23783.1
RefSeq	NP_032255.2
UniGene	Mm.19806
ProteinModelPortal	P70288
SMR	P70288
BioGrid	200260
DIP	DIP-32854N
IntAct	P70288
MINT	MINT-146936
PhosphoSite	P70288
MaxQB	P70288
PaxDb	P70288
PRIDE	P70288
Ensembl	ENSMUST00000019911
GeneID	15182
KEGG	mmu:15182
UCSC	uc007evf.1
CTD	3066
MGI	MGI:1097691
eggNOG	COG0123
GeneTree	ENSGT00530000062889
HOGENOM	HOG000225180
HOVERGEN	HBG057112
InParanoid	P70288
KO	K06067
OrthoDB	EOG7DNNTW
PhylomeDB	P70288
TreeFam	TF106171
Reactome	REACT_198649 REACT_200667 REACT_202086 REACT_214440 REACT_235780 REACT_257106
ChiTaRS	Hdac2
NextBio	287693
PRO	PR:P70288
Proteomes	UP000000589
Bgee	P70288
CleanEx	MM_HDAC2
ExpressionAtlas	P70288
Genevestigator	P70288
GO	GO:0005737 GO:0035098 GO:0000792 GO:0000118 GO:0000790 GO:0005634 GO:0016581 GO:0005657 GO:0016580 GO:0005667 GO:0017053 GO:0003682 GO:0031490 GO:0001047 GO:0019213 GO:0019899 GO:0004407 GO:0035851 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0044822 GO:0033558 GO:0000978 GO:0000980 GO:0003700 GO:0008134 GO:0043044 GO:0055013 GO:0034605 GO:0016568 GO:0032922 GO:0016358 GO:0042733 GO:0009913 GO:0061029 GO:0061198 GO:0060789 GO:0021766 GO:0016575 GO:0070932 GO:0070933 GO:0006344 GO:0043066 GO:0090090 GO:0060044 GO:2001243 GO:0010977 GO:0043433 GO:0000122 GO:0045892 GO:0030182 GO:0042475 GO:0008284 GO:0048714 GO:0045862 GO:0010870 GO:0051091 GO:0045944 GO:0006476 GO:0090311 GO:0051896 GO:0060297 GO:0042220 GO:0042493 GO:0006351
Gene3D	3.40.800.20
InterPro	IPR000286 IPR003084 IPR023801
PANTHER	PTHR10625
Pfam	PF00850
PIRSF	PIRSF037913
PRINTS	PR01270 PR01271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0034739	histone deacetylase activity (H4-K16 specific)	PMID:23516383^[1]	ECO:0000315			F		fig4. C and D show that H4K16 acetylation is greatly increased in Hdac-/- knockouts compared to wild type in mouse oocytes. fig4.C shows Immunocytochemical detection of HDAC1 and histone H4K16 acetylation, and fig4.D shows the quantification of the data from C.	complete CACAO 7900
part_of	GO:0005634	nucleus	PMID:28053041^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:28053041^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:24675724^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6NZM9	P	occurs_in:(CL:0000235) regulates_transcription_of:(ENSEMBL:ENSMUSG00000065397) part_of:(GO:0034614)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:24675724^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235) regulates_transcription_of:(ENSEMBL:ENSMUSG00000065397) part_of:(GO:0034614)	Seeded From UniProt	complete
enables	GO:0001226	RNA polymerase II transcription corepressor binding	PMID:12007404^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JJY4	F		Seeded From UniProt	complete
part_of	GO:0090571	RNA polymerase II transcription repressor complex	PMID:12007404^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:12007404^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000581)	Seeded From UniProt	complete
enables	GO:0034739	histone deacetylase activity (H4-K16 specific)	PMID:23516383^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:15226430^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:15226430^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035851	Krueppel-associated box domain binding	PMID:22391310^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9QAG8	F		Seeded From UniProt	complete
enables	GO:0035851	Krueppel-associated box domain binding	PMID:21177534^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9QAG8	F		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:15226430^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20972425^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04797	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	PMID:15226430^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	PMID:18754010^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18754010^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 MGI:MGI:1343091 PANTHER:PTN002578320 PomBase:SPAC3G9.07c SGD:S000005274 SGD:S000006272 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 RGD:1309799 RGD:619976 RGD:619977 SGD:S000005274 TAIR:locus:2098115 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 PANTHER:PTN000066122 PomBase:SPBC36.05c SGD:S000005274 UniProtKB:Q13547 UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002578320 PomBase:SPBC36.05c SGD:S000005274 SGD:S000006272 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 FB:FBgn0025825 MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c RGD:1309799 SGD:S000003162 SGD:S000005274 TAIR:locus:2162017 UniProtKB:G5EB64 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q7K6A1 UniProtKB:Q92769 WB:WBGene00001834 dictyBase:DDB_G0270338	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 MGI:MGI:108086 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c SGD:S000003162 SGD:S000005274 SGD:S000006272 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051896	regulation of protein kinase B signaling	PMID:17322895^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712002	P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:20833366^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:19503085^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108086	P	occurs_in:(EMAPA:17544) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)\|occurs_in(EMAPA:17577) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043392	negative regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035984	cellular response to trichostatin A	PMID:24137001^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:18458156^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:19380719^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:19380719^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108086	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	F		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:17182846^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O09106 UniProtKB:P05627 UniProtKB:Q60520 UniProtKB:Q60974 UniProtKB:Q9QYB2	C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	PMID:12975471^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916782	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006344	maintenance of chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17182846^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O09106 UniProtKB:P05627 UniProtKB:Q60520 UniProtKB:Q60974 UniProtKB:Q9QYB2	C		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:10888872^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22770845^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20720167^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17392792^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:24137001^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14643676^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041) part_of:(CL:0000007)\|part_of:(EMAPA:16046) part_of:(CL:1000274)	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14519686^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107157 MGI:MGI:1342291	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21093383^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902437	positive regulation of male mating behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090311	regulation of protein deacetylation	PMID:20833366^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916782	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19503085^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070932	histone H3 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070734	histone H3-K27 methylation	PMID:24137001^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061000	negative regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060297	regulation of sarcomere organization	PMID:17322895^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712002	P	regulates_o_occurs_in:(EMAPA:32748) regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060044	negative regulation of cardiac muscle cell proliferation	PMID:17322895^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712002	P	regulates_o_occurs_in:(EMAPA:32748)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055013	cardiac muscle cell development	PMID:17322895^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712002	P	occurs_in:(EMAPA:32748)	Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:12711221^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12711221^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12711221^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:12711221^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:12711221^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-573385 Reactome:R-NUL-573373 Reactome:R-MMU-9625109 Reactome:R-MMU-9017958 Reactome:R-MMU-573383 Reactome:R-MMU-573376 Reactome:R-MMU-573336	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ma, P & Schultz, RM (2013) Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. PLoS Genet. 9 e1003377 PubMed GONUTS page
↑ ^2.0 ^2.1 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page
↑ ^3.0 ^3.1 Tian, FJ et al. (2014) Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc. Res. 103 100-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Klappacher, GW et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109 169-80 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Nott, A et al. (2008) S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 455 411-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Naruse, Y et al. (2004) Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol. Cell. Biol. 24 6278-87 PubMed GONUTS page
↑ Huang, GJ et al. (2012) ZFP932 suppresses cellular Hedgehog response and Patched1 transcription. Vitam. Horm. 88 309-32 PubMed GONUTS page
↑ He, Z et al. (2011) A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J. Biol. Chem. 286 7279-89 PubMed GONUTS page
↑ Kornberg, MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12 1094-100 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Trivedi, CM et al. (2007) Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat. Med. 13 324-31 PubMed GONUTS page
↑ ^13.0 ^13.1 Trivedi, CM et al. (2010) Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev. Cell 19 450-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Ye, F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12 829-38 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Mathiyalagan, P et al. (2014) The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res. 42 790-803 PubMed GONUTS page
↑ Shang, Y et al. (2008) Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. J. Cell Biol. 181 461-73 PubMed GONUTS page
↑ ^17.0 ^17.1 Montgomery, RL et al. (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc. Natl. Acad. Sci. U.S.A. 106 7876-81 PubMed GONUTS page
↑ ^18.0 ^18.1 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page
↑ Kook, H et al. (2003) Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J. Clin. Invest. 112 863-71 PubMed GONUTS page
↑ Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page
↑ Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page
↑ Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page
↑ Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page
↑ Kantor, B et al. (2003) Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expr. Patterns 3 697-702 PubMed GONUTS page
↑ Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page
↑ Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

[PMID:23516383-1] 1.0 ^1.1 Ma, P & Schultz, RM (2013) Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. PLoS Genet. 9 e1003377 PubMed GONUTS page

[PMID:28053041-2] 2.0 ^2.1 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page

[PMID:24675724-3] 3.0 ^3.1 Tian, FJ et al. (2014) Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc. Res. 103 100-10 PubMed GONUTS page

[PMID:12007404-4] 4.0 ^4.1 ^4.2 Klappacher, GW et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109 169-80 PubMed GONUTS page

[PMID:21093383-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page

[PMID:18754010-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Nott, A et al. (2008) S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 455 411-5 PubMed GONUTS page

[PMID:15226430-7] 7.0 ^7.1 ^7.2 ^7.3 Naruse, Y et al. (2004) Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol. Cell. Biol. 24 6278-87 PubMed GONUTS page

[PMID:22391310-8] Huang, GJ et al. (2012) ZFP932 suppresses cellular Hedgehog response and Patched1 transcription. Vitam. Horm. 88 309-32 PubMed GONUTS page

[PMID:21177534-9] He, Z et al. (2011) A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J. Biol. Chem. 286 7279-89 PubMed GONUTS page

[PMID:20972425-10] Kornberg, MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12 1094-100 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17322895-12] 12.0 ^12.1 ^12.2 ^12.3 Trivedi, CM et al. (2007) Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat. Med. 13 324-31 PubMed GONUTS page

[PMID:20833366-13] 13.0 ^13.1 Trivedi, CM et al. (2010) Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev. Cell 19 450-9 PubMed GONUTS page

[PMID:19503085-14] 14.0 ^14.1 Ye, F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12 829-38 PubMed GONUTS page

[PMID:24137001-15] 15.0 ^15.1 ^15.2 Mathiyalagan, P et al. (2014) The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res. 42 790-803 PubMed GONUTS page

[PMID:18458156-16] Shang, Y et al. (2008) Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. J. Cell Biol. 181 461-73 PubMed GONUTS page

[PMID:19380719-17] 17.0 ^17.1 Montgomery, RL et al. (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc. Natl. Acad. Sci. U.S.A. 106 7876-81 PubMed GONUTS page

[PMID:17182846-18] 18.0 ^18.1 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page

[PMID:12975471-19] Kook, H et al. (2003) Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J. Clin. Invest. 112 863-71 PubMed GONUTS page

[PMID:10888872-20] Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page

[PMID:22770845-21] Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page

[PMID:20720167-22] Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page

[PMID:17392792-23] Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page

[PMID:14643676-24] Kantor, B et al. (2003) Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expr. Patterns 3 697-702 PubMed GONUTS page

[PMID:14519686-25] Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page

[PMID:10431247-26] Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page

[PMID:12711221-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

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MOUSE:HDAC2

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