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PMID:19380719

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Citation

Montgomery, RL, Hsieh, J, Barbosa, AC, Richardson, JA and Olson, EN (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc. Natl. Acad. Sci. U.S.A. 106:7876-81

Abstract

The molecular mechanism by which neural progenitor cells commit to a specified lineage of the central nervous system remains unknown. We show that HDAC1 and HDAC2 redundantly control neuronal development and are required for neuronal specification. Mice lacking HDAC1 or HDAC2 in neuronal precursors show no overt histoarchitectural phenotypes, whereas deletion of both HDAC1 and HDAC2 in developing neurons results in severe hippocampal abnormalities, absence of cerebellar foliation, disorganization of cortical neurons, and lethality by postnatal day 7. These abnormalities in brain formation can be attributed to a failure of neuronal precursors to differentiate into mature neurons and to excessive cell death. These results reveal redundant and essential roles for HDAC1 and HDAC2 in the progression of neuronal precursors to mature neurons in vivo.

Links

PubMed PMC2683090 Online version:10.1073/pnas.0902750106

Keywords

Alleles; Animals; Brain/embryology; Cell Differentiation; Cell Movement; Cerebral Cortex/metabolism; Gene Deletion; Hippocampus/embryology; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases/physiology; Mice; Models, Biological; Neurons/metabolism; Neurons/physiology; Phenotype; Repressor Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:HDAC2

acts_upstream_of_or_within

GO:0030182: neuron differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108086

P

Seeded From UniProt

complete

MOUSE:HDAC2

acts_upstream_of_or_within

GO:0021766: hippocampus development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:108086

P

Seeded From UniProt

complete

MOUSE:HDAC1

acts_upstream_of_or_within

GO:0021766: hippocampus development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1097691

P

Seeded From UniProt

complete

MOUSE:HDAC1

acts_upstream_of_or_within

GO:0030182: neuron differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1097691

P

Seeded From UniProt

complete


See also

References

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