HUMAN:HDAC2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HDAC2
Protein Name(s)	Histone deacetylase 2 HD2
External Links
UniProt	Q92769
EMBL	U31814 AK092156 AK296856 AL590398 AL671967 FO393415 CH471051 CH471051 CH471051 CH471051 BC031055
CCDS	CCDS43493.2
RefSeq	NP_001518.3
UniGene	Hs.3352
PDB	3MAX 4LXZ 4LY1
PDBsum	3MAX 4LXZ 4LY1
ProteinModelPortal	Q92769
SMR	Q92769
BioGrid	109316
DIP	DIP-24220N
IntAct	Q92769
MINT	MINT-90593
STRING	9606.ENSP00000381331
BindingDB	Q92769
ChEMBL	CHEMBL2093865
DrugBank	DB01223 DB00227 DB01303 DB00277 DB00313 DB02546
GuidetoPHARMACOLOGY	2616
PhosphoSite	Q92769
DMDM	68068066
MaxQB	Q92769
PRIDE	Q92769
DNASU	3066
Ensembl	ENST00000368632 ENST00000519065 ENST00000519108
GeneID	3066
KEGG	hsa:3066
UCSC	uc003pwc.2
CTD	3066
GeneCards	GC06M114254
HGNC	HGNC:4853
HPA	CAB005054 HPA011727
MIM	605164
neXtProt	NX_Q92769
PharmGKB	PA29227
GeneTree	ENSGT00530000062889
HOGENOM	HOG000225180
HOVERGEN	HBG057112
InParanoid	Q92769
KO	K06067
PhylomeDB	Q92769
TreeFam	TF106171
Reactome	REACT_118780 REACT_13695 REACT_160243 REACT_160254 REACT_200856 REACT_228222 REACT_24970 REACT_953
SABIO-RK	Q92769
ChiTaRS	HDAC2
EvolutionaryTrace	Q92769
GeneWiki	Histone_deacetylase_2
GenomeRNAi	3066
NextBio	12129
PRO	PR:Q92769
Proteomes	UP000005640
Bgee	Q92769
CleanEx	HS_HDAC2
ExpressionAtlas	Q92769
Genevestigator	Q92769
GO	GO:0005737 GO:0035098 GO:0000792 GO:0000790 GO:0005654 GO:0005634 GO:0016581 GO:0043234 GO:0005657 GO:0016580 GO:0005667 GO:0003682 GO:0031490 GO:0001047 GO:0019213 GO:0019899 GO:0004407 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0044822 GO:0033558 GO:0001103 GO:0043565 GO:0003700 GO:0008134 GO:0043044 GO:0007596 GO:0055013 GO:0034605 GO:0006338 GO:0032922 GO:0016358 GO:0042733 GO:0009913 GO:0061029 GO:0061198 GO:0060789 GO:0021766 GO:0016575 GO:0070932 GO:0070933 GO:0006344 GO:0043066 GO:0090090 GO:0060044 GO:0045786 GO:2001243 GO:0045347 GO:0010977 GO:0043433 GO:0000122 GO:0045892 GO:0048011 GO:0042475 GO:0008284 GO:0032967 GO:0048714 GO:0045862 GO:0010870 GO:0051091 GO:0045944 GO:0045893 GO:0090311 GO:0051896 GO:0060297 GO:0042220 GO:0042493 GO:0006351
Gene3D	3.40.800.20
InterPro	IPR000286 IPR003084 IPR023801
PANTHER	PTHR10625
Pfam	PF00850
PIRSF	PIRSF037913
PRINTS	PR01270 PR01271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016581	NuRD complex	PMID:22926524^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:28046085^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:28046085^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N108	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:28046085^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N344	F	has_direct_input:(InterPro:IPR000949)	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:17785205^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24970816^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24970816^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0031492	nucleosomal DNA binding	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:16217013^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19041327^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19372552^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19041327^[7]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19276356^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19041327^[7]	ECO:0000305	curator inference used in manual assertion	GO:0000122	P		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	PMID:19041327^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045347	negative regulation of MHC class II biosynthetic process	PMID:19041327^[7]	ECO:0000305	curator inference used in manual assertion	GO:0000122	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19276356^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:19041327^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:19041327^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	PMID:19041327^[7]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:17827154^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	PMID:17827154^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:19372552^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:18754010^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:18316616^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	PMID:21093383^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18347167^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17827154^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02086	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17827154^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08047	F		Seeded From UniProt	complete
involved_in	GO:0006344	maintenance of chromatin silencing	PMID:19372552^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:17827154^[10]	ECO:0000305	curator inference used in manual assertion	GO:0004407	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18347167^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:16642021^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:22926524^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96BF6	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19041327^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19276356^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:20075857^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11641274^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NWT6	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11062478^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	F		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:19644445^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	PMID:14966270^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70288	F		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 MGI:MGI:1343091 PANTHER:PTN002578320 PomBase:SPAC3G9.07c SGD:S000005274 SGD:S000006272 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 RGD:1309799 RGD:619976 RGD:619977 SGD:S000005274 TAIR:locus:2098115 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 PANTHER:PTN000066122 PomBase:SPBC36.05c SGD:S000005274 UniProtKB:Q13547 UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002578320 PomBase:SPBC36.05c SGD:S000005274 SGD:S000006272 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 FB:FBgn0025825 MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c RGD:1309799 SGD:S000003162 SGD:S000005274 TAIR:locus:2162017 UniProtKB:G5EB64 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q7K6A1 UniProtKB:Q92769 WB:WBGene00001834 dictyBase:DDB_G0270338	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 MGI:MGI:108086 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c SGD:S000003162 SGD:S000005274 SGD:S000006272 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	F		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:1902437	positive regulation of male mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0061000	negative regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	F		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	C		Seeded From UniProt	complete
involved_in	GO:0003300	cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7ENH8 ensembl:ENSRNOP00000000742	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	P		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12711221^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-996727 Reactome:R-HSA-9005995 Reactome:R-HSA-8943780 Reactome:R-HSA-6805650 Reactome:R-HSA-4616015 Reactome:R-HSA-3769447	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Derwish, R et al. (2017) Differential HDAC1 and 2 Recruitment by Members of the MIER Family. PLoS ONE 12 e0169338 PubMed GONUTS page
↑ Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, J et al. (2014) The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget 5 5153-64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Kong, X et al. (2009) HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J. Mol. Cell. Cardiol. 46 292-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Marchion, DC et al. (2009) HDAC2 regulates chromatin plasticity and enhances DNA vulnerability. Mol. Cancer Ther. 8 794-801 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Liu, R et al. (2009) FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 69 2252-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
↑ Nott, A et al. (2008) S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 455 411-5 PubMed GONUTS page
↑ Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Weichert, W et al. (2008) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res. 14 1669-77 PubMed GONUTS page
↑ Ropero, S et al. (2006) A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat. Genet. 38 566-9 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page
↑ Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page
↑ Tsai, SC et al. (2000) Histone deacetylase interacts directly with DNA topoisomerase II. Nat. Genet. 26 349-53 PubMed GONUTS page
↑ Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page
↑ Doyon, Y et al. (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24 1884-96 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

[PMID:22926524-1] 1.0 ^1.1 Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page

[PMID:28046085-2] 2.0 ^2.1 ^2.2 Derwish, R et al. (2017) Differential HDAC1 and 2 Recruitment by Members of the MIER Family. PLoS ONE 12 e0169338 PubMed GONUTS page

[PMID:17785205-3] Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page

[PMID:24970816-4] 4.0 ^4.1 Liu, J et al. (2014) The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget 5 5153-64 PubMed GONUTS page

[PMID:16217013-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page

[PMID:21093383-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page

[PMID:19041327-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Kong, X et al. (2009) HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J. Mol. Cell. Cardiol. 46 292-9 PubMed GONUTS page

[PMID:19372552-8] 8.0 ^8.1 ^8.2 Marchion, DC et al. (2009) HDAC2 regulates chromatin plasticity and enhances DNA vulnerability. Mol. Cancer Ther. 8 794-801 PubMed GONUTS page

[PMID:19276356-9] 9.0 ^9.1 ^9.2 Liu, R et al. (2009) FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 69 2252-9 PubMed GONUTS page

[PMID:17827154-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page

[PMID:18754010-11] Nott, A et al. (2008) S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 455 411-5 PubMed GONUTS page

[PMID:18316616-12] Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page

[PMID:18347167-13] 13.0 ^13.1 Weichert, W et al. (2008) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res. 14 1669-77 PubMed GONUTS page

[PMID:16642021-14] Ropero, S et al. (2006) A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat. Genet. 38 566-9 PubMed GONUTS page

[PMID:22681889-15] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:20075857-16] Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page

[PMID:11641274-17] Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page

[PMID:11062478-18] Tsai, SC et al. (2000) Histone deacetylase interacts directly with DNA topoisomerase II. Nat. Genet. 26 349-53 PubMed GONUTS page

[PMID:19644445-19] Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page

[PMID:14966270-20] Doyon, Y et al. (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24 1884-96 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12711221-22] Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

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