HUMAN:EZH2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EZH2 (synonyms: KMT6)
Protein Name(s)	Histone-lysine N-methyltransferase EZH2 ENX-1 Enhancer of zeste homolog 2 Lysine N-methyltransferase 6
External Links
UniProt	Q15910
EMBL	X95653 U61145 AK302216 AK092676 AK293239 AK314291 AC006323 AC073140 CH471146 CH471146 BC010858 U52965
CCDS	CCDS56516.1 CCDS56517.1 CCDS56518.1 CCDS5891.1 CCDS5892.1
PIR	G02838
RefSeq	NP_001190176.1 NP_001190177.1 NP_001190178.1 NP_004447.2 NP_694543.1 XP_006715946.1 XP_006715948.1
UniGene	Hs.444082 Hs.732308
PDB	2C6V 4MI0 4MI5
PDBsum	2C6V 4MI0 4MI5
ProteinModelPortal	Q15910
SMR	Q15910
BioGrid	108446
DIP	DIP-34002N
IntAct	Q15910
MINT	MINT-1371596
STRING	9606.ENSP00000320147
BindingDB	Q15910
ChEMBL	CHEMBL2189110
GuidetoPHARMACOLOGY	2654
PhosphoSite	Q15910
DMDM	3334180
MaxQB	Q15910
PaxDb	Q15910
PRIDE	Q15910
DNASU	2146
Ensembl	ENST00000320356 ENST00000350995 ENST00000460911 ENST00000476773 ENST00000478654 ENST00000483967
GeneID	2146
KEGG	hsa:2146
UCSC	uc003wfb.2 uc003wfc.2 uc003wfd.2 uc011kug.2 uc011kuh.2
CTD	2146
GeneCards	GC07M148504
GeneReviews	EZH2
HGNC	HGNC:3527
HPA	CAB009589 HPA029131
MIM	277590 601573
neXtProt	NX_Q15910
Orphanet	3447
PharmGKB	PA27939
eggNOG	COG2940
GeneTree	ENSGT00760000118855
HOVERGEN	HBG002453
InParanoid	Q15910
KO	K11430
OMA	NRDDKES
OrthoDB	EOG7VB2DR
PhylomeDB	Q15910
TreeFam	TF314509
Reactome	REACT_169436 REACT_200808
SignaLink	Q15910
ChiTaRS	EZH2
GeneWiki	EZH2
GenomeRNAi	2146
NextBio	8675
PRO	PR:Q15910
Proteomes	UP000005640
Bgee	Q15910
CleanEx	HS_EZH2
ExpressionAtlas	Q15910
Genevestigator	Q15910
GO	GO:0005737 GO:0035098 GO:0000790 GO:0005654 GO:0005634 GO:0045120 GO:0003682 GO:0031490 GO:0001047 GO:0003677 GO:0042054 GO:0046976 GO:0003723 GO:0043565 GO:0070301 GO:0021695 GO:0006325 GO:0006306 GO:0070314 GO:0070734 GO:0045605 GO:2000134 GO:0045814 GO:0048387 GO:0051154 GO:0034244 GO:0000122 GO:0045892 GO:0010718 GO:0043406 GO:0071902 GO:0032320 GO:0071168 GO:0042127 GO:0042752 GO:0014013 GO:0006355 GO:0048511 GO:0006351
InterPro	IPR026489 IPR021654 IPR001005 IPR001214
Pfam	PF11616 PF00856
SMART	SM00717 SM00317
PROSITE	PS51633 PS50280

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0000781	chromosome, telomeric region	PMID:9214638^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38827	C	Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:9214638^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38827	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18713946^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902808	positive regulation of cell cycle G1/S phase transition	PMID:18713946^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001005	F	Seeded From UniProt	complete
involved_in	GO:0016571	histone methylation	PMID:26694085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042054	histone methyltransferase activity	PMID:26694085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:24623306^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:24623306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046976	histone methyltransferase activity (H3-K27 specific)	PMID:22323599^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61188	F	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:16717091^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:19734898^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:19734898^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070734	histone H3-K27 methylation	PMID:24474760^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	PMID:16179254^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16179254^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:24474760^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:23273982^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:23104054^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:20075857^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20154697^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042054	histone methyltransferase activity	PMID:15385962^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	PMID:15385962^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	PMID:19144645^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19144645^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
involved_in	GO:0070734	histone H3-K27 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	F	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFE2 ensembl:ENSRNOP00000008149	P	Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:1904772	response to tetrachloromethane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0098532	histone H3-K27 trimethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0070734	histone H3-K27 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0070314	G1 to G0 transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0051154	negative regulation of striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0045605	negative regulation of epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
part_of	GO:0045120	pronucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	C	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0042054	histone methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0036333	hepatocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0035984	cellular response to trichostatin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	C	Seeded From UniProt	complete
involved_in	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0021695	cerebellar cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0016571	histone methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0016279	protein-lysine N-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0014898	cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0014013	regulation of gliogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61188 ensembl:ENSMUSP00000080419	P	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021654	F	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.43	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:8921387^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:8921387^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8954776^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046976	histone methyltransferase activity (H3-K27 specific)	PMID:24474760^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	Reactome:R-HSA-212300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	Reactome:R-HSA-5638332	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016279	protein-lysine N-methyltransferase activity	Reactome:R-HSA-212269 Reactome:R-HSA-212263	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8954110 Reactome:R-HSA-5638332 Reactome:R-HSA-3240957 Reactome:R-HSA-3240783 Reactome:R-HSA-3240295 Reactome:R-HSA-212269 Reactome:R-HSA-212263 Reactome:R-HSA-212252 Reactome:R-HSA-212222	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Laible, G et al. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16 3219-32 PubMed GONUTS page
↑ ^2.0 ^2.1 Sander, S et al. (2008) MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 112 4202-12 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Cohen, AS et al. (2016) Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro. Hum. Mutat. 37 301-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
↑ McCabe, MT et al. (2012) Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl. Acad. Sci. U.S.A. 109 2989-94 PubMed GONUTS page
↑ Etchegaray, JP et al. (2006) The polycomb group protein EZH2 is required for mammalian circadian clock function. J. Biol. Chem. 281 21209-15 PubMed GONUTS page
↑ ^8.0 ^8.1 Buschbeck, M et al. (2009) The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat. Struct. Mol. Biol. 16 1074-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Min, J et al. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat. Med. 16 286-94 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Chu, CS et al. (2014) O-GlcNAcylation regulates EZH2 protein stability and function. Proc. Natl. Acad. Sci. U.S.A. 111 1355-60 PubMed GONUTS page
↑ ^11.0 ^11.1 Epping, MT et al. (2005) The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell 122 835-47 PubMed GONUTS page
↑ Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page
↑ Ballaré, C et al. (2012) Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat. Struct. Mol. Biol. 19 1257-65 PubMed GONUTS page
↑ Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page
↑ ^15.0 ^15.1 Pasini, D et al. (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23 4061-71 PubMed GONUTS page
↑ ^16.0 ^16.1 Trojer, P et al. (2009) Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J. Biol. Chem. 284 8395-405 PubMed GONUTS page
↑ ^17.0 ^17.1 Abel, KJ et al. (1996) Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics 37 161-71 PubMed GONUTS page
↑ Chen, H et al. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38 30-7 PubMed GONUTS page

[PMID:9214638-1] 1.0 ^1.1 Laible, G et al. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16 3219-32 PubMed GONUTS page

[PMID:18713946-2] 2.0 ^2.1 Sander, S et al. (2008) MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 112 4202-12 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26694085-4] 4.0 ^4.1 Cohen, AS et al. (2016) Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro. Hum. Mutat. 37 301-7 PubMed GONUTS page

[PMID:24623306-5] 5.0 ^5.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page

[PMID:22323599-6] McCabe, MT et al. (2012) Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl. Acad. Sci. U.S.A. 109 2989-94 PubMed GONUTS page

[PMID:16717091-7] Etchegaray, JP et al. (2006) The polycomb group protein EZH2 is required for mammalian circadian clock function. J. Biol. Chem. 281 21209-15 PubMed GONUTS page

[PMID:19734898-8] 8.0 ^8.1 Buschbeck, M et al. (2009) The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat. Struct. Mol. Biol. 16 1074-9 PubMed GONUTS page

[PMID:20154697-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Min, J et al. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat. Med. 16 286-94 PubMed GONUTS page

[PMID:24474760-10] 10.0 ^10.1 ^10.2 Chu, CS et al. (2014) O-GlcNAcylation regulates EZH2 protein stability and function. Proc. Natl. Acad. Sci. U.S.A. 111 1355-60 PubMed GONUTS page

[PMID:16179254-11] 11.0 ^11.1 Epping, MT et al. (2005) The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell 122 835-47 PubMed GONUTS page

[PMID:23273982-12] Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page

[PMID:23104054-13] Ballaré, C et al. (2012) Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat. Struct. Mol. Biol. 19 1257-65 PubMed GONUTS page

[PMID:20075857-14] Pasini, D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 306-10 PubMed GONUTS page

[PMID:15385962-15] 15.0 ^15.1 Pasini, D et al. (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23 4061-71 PubMed GONUTS page

[PMID:19144645-16] 16.0 ^16.1 Trojer, P et al. (2009) Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J. Biol. Chem. 284 8395-405 PubMed GONUTS page

[PMID:8921387-17] 17.0 ^17.1 Abel, KJ et al. (1996) Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics 37 161-71 PubMed GONUTS page

[PMID:8954776-18] Chen, H et al. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38 30-7 PubMed GONUTS page

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