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MOUSE:SIRT1
Contents
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045768 |
positive regulation of anti-apoptosis |
ECO:0000314 |
P |
Figure 3 |
complete | |||||
|
involved_in |
GO:1900113 |
negative regulation of histone H3-K9 trimethylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(ENSEMBL:ENSMUSG00000035783)|has_direct_input:(ENSEMBL:ENSMUSG00000032085) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_transcription_of:(ENSEMBL:ENSMUSG00000035783)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000032085)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000015605)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000005583)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000020542) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051152 |
positive regulation of smooth muscle cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010883 |
regulation of lipid storage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904179 |
positive regulation of adipose tissue development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010934 |
macrophage cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030225 |
macrophage differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090335 |
regulation of brown fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033210 |
leptin-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044321 |
response to leptin |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O35426) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902237 |
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902166 |
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050872 |
white fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035358 |
regulation of peroxisome proliferator activated receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009267 |
cellular response to starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006642 |
triglyceride mobilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0000948)|has_direct_input(UniProtKB:P11103) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000774 |
positive regulation of cellular senescence |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000773 |
negative regulation of cellular senescence |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000757 |
negative regulation of peptidyl-lysine acetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000481 |
positive regulation of cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000480 |
negative regulation of cAMP-dependent protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000111 |
positive regulation of macrophage apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070857 |
regulation of bile acid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055089 |
fatty acid homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045739 |
positive regulation of DNA repair |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043425 |
bHLH transcription factor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035356 |
cellular triglyceride homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0035098 |
ESC/E(Z) complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034391 |
regulation of smooth muscle cell apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032868 |
response to insulin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032071 |
regulation of endodeoxyribonuclease activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031393 |
negative regulation of prostaglandin biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019213 |
deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010875 |
positive regulation of cholesterol efflux |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007346 |
regulation of mitotic cell cycle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002821 |
positive regulation of adaptive immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001678 |
cellular glucose homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000785 |
chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000731 |
DNA synthesis involved in DNA repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000720 |
pyrimidine dimer repair by nucleotide-excision repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000012 |
single strand break repair |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070932 |
histone H3 deacetylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135607 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000119154 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033553 |
rDNA heterochromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872223 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135607 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872223 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872223 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135607 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135607 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000774 |
positive regulation of cellular senescence |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000773 |
negative regulation of cellular senescence |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000757 |
negative regulation of peptidyl-lysine acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000655 |
negative regulation of cellular response to testosterone stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000619 |
negative regulation of histone H4-K16 acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000614 |
positive regulation of thyroid-stimulating hormone secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000481 |
positive regulation of cAMP-dependent protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000480 |
negative regulation of cAMP-dependent protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000270 |
negative regulation of fibroblast apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1990830 |
cellular response to leukemia inhibitory factor |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990254 |
keratin filament binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904646 |
cellular response to amyloid-beta |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903427 |
negative regulation of reactive oxygen species biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901984 |
negative regulation of protein acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901984 |
negative regulation of protein acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88276 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1900181 |
negative regulation of protein localization to nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0097009 |
energy homeostasis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090400 |
stress-induced premature senescence |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090312 |
positive regulation of protein deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071900 |
regulation of protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071441 |
negative regulation of histone H3-K14 acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070932 |
histone H3 deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070932 |
histone H3 deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070914 |
UV-damage excision repair |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061051 |
positive regulation of cell growth involved in cardiac muscle cell development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060548 |
negative regulation of cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060125 |
negative regulation of growth hormone secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051574 |
positive regulation of histone H3-K9 methylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051097 |
negative regulation of helicase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045739 |
positive regulation of DNA repair |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045722 |
positive regulation of gluconeogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045722 |
positive regulation of gluconeogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045471 |
response to ethanol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045348 |
positive regulation of MHC class II biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043425 |
bHLH transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043422 |
protein kinase B binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043398 |
HLH domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043392 |
negative regulation of DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042981 |
regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042595 |
behavioral response to starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2677369 |
P |
has_participant:(EMAPA:35417) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042393 |
histone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035774 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035257 |
nuclear hormone receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0035098 |
ESC/E(Z) complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034983 |
peptidyl-lysine deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033553 |
rDNA heterochromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032071 |
regulation of endodeoxyribonuclease activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031937 |
positive regulation of chromatin silencing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031648 |
protein destabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030308 |
negative regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019213 |
deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018394 |
peptidyl-lysine acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016605 |
PML body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016575 |
histone deacetylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107187 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016575 |
histone deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016575 |
histone deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014858 |
positive regulation of skeletal muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010629 |
negative regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010460 |
positive regulation of heart rate |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007346 |
regulation of mitotic cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2448246 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006476 |
protein deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006476 |
protein deacetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006344 |
maintenance of chromatin silencing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006343 |
establishment of chromatin silencing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006325 |
chromatin organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005677 |
chromatin silencing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000349) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308542 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002821 |
positive regulation of adaptive immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001542 |
ovulation from ovarian follicle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2448246 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001525 |
angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000720 |
pyrimidine dimer repair by nucleotide-excision repair |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000183 |
chromatin silencing at rDNA |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000012 |
single strand break repair |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000774 |
positive regulation of cellular senescence |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000773 |
negative regulation of cellular senescence |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000757 |
negative regulation of peptidyl-lysine acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000655 |
negative regulation of cellular response to testosterone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000619 |
negative regulation of histone H4-K16 acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000481 |
positive regulation of cAMP-dependent protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000480 |
negative regulation of cAMP-dependent protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:1990254 |
keratin filament binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901984 |
negative regulation of protein acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090400 |
stress-induced premature senescence |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071900 |
regulation of protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071441 |
negative regulation of histone H3-K14 acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070932 |
histone H3 deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070914 |
UV-damage excision repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051574 |
positive regulation of histone H3-K9 methylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051097 |
negative regulation of helicase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045739 |
positive regulation of DNA repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045722 |
positive regulation of gluconeogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045348 |
positive regulation of MHC class II biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043425 |
bHLH transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043398 |
HLH domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042393 |
histone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035257 |
nuclear hormone receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035098 |
ESC/E(Z) complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034983 |
peptidyl-lysine deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033553 |
rDNA heterochromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032071 |
regulation of endodeoxyribonuclease activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031937 |
positive regulation of chromatin silencing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019213 |
deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018394 |
peptidyl-lysine acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016605 |
PML body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007346 |
regulation of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006344 |
maintenance of chromatin silencing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006343 |
establishment of chromatin silencing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005677 |
chromatin silencing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002821 |
positive regulation of adaptive immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000720 |
pyrimidine dimer repair by nucleotide-excision repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000183 |
chromatin silencing at rDNA |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000012 |
single strand break repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96EB6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024QZQ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024QZQ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024QZQ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024QZQ1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-MMU-9626966 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0007517 |
muscle organ development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016605 |
PML body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lafontaine-Lacasse, M et al. (2011) Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells. J. Endocrinol. 208 41-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Yu, X et al. (2015) Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death Differ. 22 1170-80 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Xu, F et al. (2012) Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology 153 1706-16 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Ramadori, G et al. (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 12 78-87 PubMed GONUTS page
- ↑ 5.0 5.1 Guo, X et al. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285 13223-32 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page
- ↑ 8.0 8.1 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page
- ↑ Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page
- ↑ 10.0 10.1 Luo, J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-48 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Picard, F et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 771-6 PubMed GONUTS page
- ↑ 12.0 12.1 Vaziri, H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 149-59 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Rajamohan, SB et al. (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell. Biol. 29 4116-29 PubMed GONUTS page
- ↑ Lan, F et al. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283 27628-35 PubMed GONUTS page
- ↑ 15.0 15.1 Zhang, R et al. (2010) SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 285 7097-110 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Yuan, Z et al. (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 149-62 PubMed GONUTS page
- ↑ Chanda, D et al. (2010) Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res. 38 4607-19 PubMed GONUTS page
- ↑ 18.0 18.1 Gerhart-Hines, Z et al. (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26 1913-23 PubMed GONUTS page
- ↑ 19.0 19.1 Ming, M et al. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U.S.A. 107 22623-8 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Kornberg, MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12 1094-100 PubMed GONUTS page
- ↑ 21.0 21.1 Daitoku, H et al. (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. U.S.A. 101 10042-7 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 22.3 Li, X et al. (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28 91-106 PubMed GONUTS page
- ↑ 23.0 23.1 Kume, S et al. (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282 151-8 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 Wang, F et al. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6 505-14 PubMed GONUTS page
- ↑ 25.0 25.1 Zhou, Y et al. (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat. Cell Biol. 11 1010-6 PubMed GONUTS page
- ↑ 26.0 26.1 Zhang, J (2007) The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282 34356-64 PubMed GONUTS page
- ↑ Ghosh, HS et al. (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5 e9199 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 Vaquero, A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450 440-4 PubMed GONUTS page
- ↑ Lee, IH et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 3374-9 PubMed GONUTS page
- ↑ Powell, MJ et al. (2011) Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 71 964-75 PubMed GONUTS page
- ↑ 31.0 31.1 Chen, WY et al. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 437-48 PubMed GONUTS page
- ↑ Tanno, M et al. (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282 6823-32 PubMed GONUTS page
- ↑ Rodgers, JT et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 113-8 PubMed GONUTS page
- ↑ 34.00 34.01 34.02 34.03 34.04 34.05 34.06 34.07 34.08 34.09 34.10 34.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Muth, V et al. (2001) Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20 1353-62 PubMed GONUTS page
- ↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
- ↑ Parker, JA et al. (2012) Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J. Neurosci. 32 12630-40 PubMed GONUTS page
- ↑ 38.0 38.1 Revollo, JR et al. (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279 50754-63 PubMed GONUTS page
- ↑ Satoh, A et al. (2010) SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J. Neurosci. 30 10220-32 PubMed GONUTS page
- ↑ Miyashita, H et al. (2012) Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE 7 e46459 PubMed GONUTS page
- ↑ 41.0 41.1 Imai, S et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 795-800 PubMed GONUTS page
- ↑ Haigis, MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-54 PubMed GONUTS page
- ↑ Tiberi, L et al. (2012) BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat. Neurosci. 15 1627-35 PubMed GONUTS page
- ↑ 44.0 44.1 44.2 McBurney, MW et al. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23 38-54 PubMed GONUTS page
- ↑ Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page
c
- GO:1990830 ! cellular response to leukemia inhibitory factor
- GO:0009267 ! cellular response to starvation
- GO:0071479 ! cellular response to ionizing radiation
- GO:0071456 ! cellular response to hypoxia
- GO:0071356 ! cellular response to tumor necrosis factor
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:1904646 ! cellular response to amyloid-beta
- GO:0030154 ! cell differentiation
- GO:0042632 ! cholesterol homeostasis
- Chordata
- GO:0000785 ! chromatin
- GO:0006325 ! chromatin organization
- GO:0005677 ! chromatin silencing complex
- GO:0032922 ! circadian regulation of gene expression
- GO:0007623 ! circadian rhythm
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
d
e
h
i
- GO:0042802 ! identical protein binding
- GO:0001678 ! intracellular glucose homeostasis
- GO:0035356 ! intracellular triglyceride homeostasis
- GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
m
- GO:0010934 ! macrophage cytokine production
- GO:0030225 ! macrophage differentiation
- GO:0006344 ! maintenance of chromatin silencing
- Mammalia
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0005739 ! mitochondrion
- GO:0051019 ! mitogen-activated protein kinase binding
- GO:0007275 ! multicellular organism development
- Muridae
- Murinae
- Muroidea
- Mus
- GO:0007517 ! muscle organ development
- Mus musculus
n
- GO:0070403 ! NAD+ binding
- GO:0034979 ! NAD-dependent protein lysine deacetylase activity
- GO:0051097 ! negative regulation of helicase activity
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0010629 ! negative regulation of gene expression
- GO:2000655 ! negative regulation of cellular response to testosterone stimulus
- GO:0010667 ! negative regulation of cardiac muscle cell apoptotic process
- GO:2000270 ! negative regulation of fibroblast apoptotic process
- GO:0043066 ! negative regulation of apoptotic process
- GO:0043124 ! negative regulation of canonical NF-kappaB signal transduction
- GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process
- GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- GO:1901984 ! negative regulation of protein acetylation
- GO:1900181 ! negative regulation of protein localization to nucleus
- GO:0030308 ! negative regulation of cell growth
- GO:2000480 ! negative regulation of cAMP-dependent protein kinase activity
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0051898 ! negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0031393 ! negative regulation of prostaglandin biosynthetic process
- GO:0043392 ! negative regulation of DNA binding
- GO:0060766 ! negative regulation of androgen receptor signaling pathway
- GO:0060125 ! negative regulation of growth hormone secretion
- GO:0043518 ! negative regulation of DNA damage response, signal transduction by p53 class mediator
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:2000757 ! negative regulation of peptidyl-lysine acetylation
- GO:0045599 ! negative regulation of fat cell differentiation
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0042326 ! negative regulation of phosphorylation
- GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
- GO:0032007 ! negative regulation of TOR signaling
- GO:1902166 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:2000773 ! negative regulation of cellular senescence
- GO:0000790 ! nuclear chromatin
- GO:0005635 ! nuclear envelope
- GO:0005719 ! nuclear euchromatin
- GO:0005720 ! nuclear heterochromatin
- GO:0035257 ! nuclear hormone receptor binding
- GO:0005637 ! nuclear inner membrane
- GO:0005730 ! nucleolus
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:0016575 ! obsolete histone deacetylation
- GO:0070932 ! obsolete histone H3 deacetylation
- GO:1990619 ! obsolete histone H3-K9 deacetylation
- GO:0061647 ! obsolete histone H3-K9 modification
- GO:0071441 ! obsolete negative regulation of histone H3-K14 acetylation
- GO:1901215 ! obsolete negative regulation of neuron death
- GO:1900113 ! obsolete negative regulation of histone H3-K9 trimethylation
- GO:0060548 ! obsolete negative regulation of cell death
- GO:2000619 ! obsolete negative regulation of histone H4-K16 acetylation
- GO:0031937 ! obsolete positive regulation of chromatin silencing
- GO:0014068 ! obsolete positive regulation of phosphatidylinositol 3-kinase signaling
- GO:0045768 ! obsolete positive regulation of anti-apoptosis
- GO:0043280 ! obsolete positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0051574 ! obsolete positive regulation of histone H3-K9 methylation
- GO:0097755 ! obsolete positive regulation of blood vessel diameter
- GO:0008022 ! obsolete protein C-terminus binding
- GO:0001542 ! ovulation from ovarian follicle
p
- GO:0002039 ! p53 binding
- GO:0034983 ! peptidyl-lysine deacetylation
- GO:0018394 ! peptidyl-lysine acetylation
- GO:0016605 ! PML body
- GO:0016239 ! positive regulation of macroautophagy
- GO:1904179 ! positive regulation of adipose tissue development
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0010976 ! positive regulation of neuron projection development
- GO:2000614 ! positive regulation of thyroid-stimulating hormone secretion
- GO:0010460 ! positive regulation of heart rate
- GO:0051152 ! positive regulation of smooth muscle cell differentiation
- GO:0045722 ! positive regulation of gluconeogenesis
- GO:2000774 ! positive regulation of cellular senescence
- GO:1902237 ! positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:0043065 ! positive regulation of apoptotic process
- GO:0002821 ! positive regulation of adaptive immune response
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010875 ! positive regulation of cholesterol efflux
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0045766 ! positive regulation of angiogenesis
- GO:0014858 ! positive regulation of skeletal muscle cell proliferation
- GO:0035774 ! positive regulation of insulin secretion involved in cellular response to glucose stimulus
- GO:0045348 ! positive regulation of MHC class II biosynthetic process
- GO:0043536 ! positive regulation of blood vessel endothelial cell migration
- GO:0046628 ! positive regulation of insulin receptor signaling pathway
- GO:0090312 ! positive regulation of protein deacetylation
- GO:0061051 ! positive regulation of cell growth involved in cardiac muscle cell development
- GO:0045739 ! positive regulation of DNA repair
- GO:2000481 ! positive regulation of cAMP-dependent protein kinase activity
- GO:2000111 ! positive regulation of macrophage apoptotic process
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0006476 ! protein deacetylation
- GO:0031648 ! protein destabilization
- GO:0019904 ! protein domain specific binding
- GO:0043422 ! protein kinase B binding
- GO:0033558 ! protein lysine deacetylase activity
- GO:0016567 ! protein ubiquitination
- GO:0000720 ! pyrimidine dimer repair by nucleotide-excision repair
r
- GO:0000183 ! rDNA heterochromatin formation
- GO:0033553 ! rDNA heterochromatin
- GO:0071900 ! regulation of protein serine/threonine kinase activity
- GO:0010906 ! regulation of glucose metabolic process
- GO:0010883 ! regulation of lipid storage
- GO:0032071 ! regulation of endodeoxyribonuclease activity
- GO:0042981 ! regulation of apoptotic process
- GO:0090335 ! regulation of brown fat cell differentiation
- GO:0007346 ! regulation of mitotic cell cycle
- GO:0070857 ! regulation of bile acid biosynthetic process
- GO:0034391 ! regulation of smooth muscle cell apoptotic process
- GO:0042127 ! regulation of cell population proliferation
- GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway
- GO:0006979 ! response to oxidative stress
- GO:0045471 ! response to ethanol
- GO:0042542 ! response to hydrogen peroxide
- GO:0032868 ! response to insulin
- GO:0044321 ! response to leptin
- GO:0048511 ! rhythmic process
- GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding
- Rodentia
- GO:0006364 ! rRNA processing
s
t
