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PMID:21189328

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Citation

Powell, MJ, Casimiro, MC, Cordon-Cardo, C, He, X, Yeow, WS, Wang, C, McCue, PA, McBurney, MW and Pestell, RG (2011) Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 71:964-75

Abstract

The Sirtuin family of proteins (SIRT) encode a group of evolutionarily conserved, NAD-dependent histone deacetylases, involved in many biological pathways. SIRT1, the human homologue of the yeast Silent Information Regulator 2 (Sir2) gene, deacetylates histones, p300, p53, and the androgen receptor. Autophagy is required for the degradation of damaged organelles and long-lived proteins, as well as for the development of glands such as the breast and prostate. Herein, homozygous deletion of the Sirt1 gene in mice resulted in prostatic intraepithelial neoplasia (PIN) associated with reduced autophagy. Genome-wide gene expression analysis of Sirt1(-/-) prostates demonstrated that endogenous Sirt1 repressed androgen responsive gene expression and induced autophagy in the prostate. Sirt1 induction of autophagy occurred at the level of autophagosome maturation and completion in cultured prostate cancer cells. These studies provide novel evidence for a checkpoint function of Sirt1 in the development of PIN and further highlight a role for SIRT1 as a tumor suppressor in the prostate.

Links

PubMed PMC3033220 Online version:10.1158/0008-5472.CAN-10-3172

Keywords

Animals; Autophagy/genetics; Cell Growth Processes/genetics; Cell Line, Tumor; Male; Mice; Mice, Transgenic; Prostatic Intraepithelial Neoplasia/genetics; Prostatic Intraepithelial Neoplasia/metabolism; Prostatic Intraepithelial Neoplasia/pathology; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; RNA, Messenger/genetics; Receptors, Androgen/metabolism; Signal Transduction; Sirtuin 1/genetics; Sirtuin 1/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SIRT1

involved_in

GO:0016239: positive regulation of macroautophagy

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIR1

involved_in

GO:0016239: positive regulation of macroautophagy

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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