Category:GO:0017136 ! histone deacetylase activity, NAD-dependent

name: histone deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide." [PMID:24691964, PMID:28450737]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
synonym: "histone deacetylase activity" BROAD []
synonym: "NAD-dependent histone deacetylase activity" EXACT []
synonym: "NAD-dependent histone lysine deacetylase activity" EXACT []
synonym: "SIR2" RELATED []
synonym: "sirtuin" NARROW []
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0034979 ! NAD-dependent protein lysine deacetylase activity

AmiGO <GOterm>GO:0017136</GOterm>
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