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HUMAN:PHF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PHF1 (synonyms: PCL1)
Protein Name(s) PHD finger protein 1

Protein PHF1 hPHF1 Polycomb-like protein 1 hPCl1

External Links
UniProt O43189
EMBL AF029678
AF052205
AL662799
AL662799
AL021366
AL021366
AL050332
AL050332
BX088650
BX088650
CH471081
CH471081
BC008834
CCDS CCDS4777.1
CCDS4778.1
RefSeq NP_002627.1
NP_077084.1
UniGene Hs.166204
PDB 2E5P
2M0O
4HCZ
PDBsum 2E5P
2M0O
4HCZ
ProteinModelPortal O43189
SMR O43189
BioGrid 111271
DIP DIP-34001N
IntAct O43189
MINT MINT-1437706
PhosphoSite O43189
MaxQB O43189
PaxDb O43189
PRIDE O43189
DNASU 5252
Ensembl ENST00000374512
ENST00000374516
ENST00000427869
ENST00000454914
GeneID 5252
KEGG hsa:5252
UCSC uc003oeh.3
uc003oei.3
CTD 5252
GeneCards GC06P033379
GC06Po33517
HGNC HGNC:8919
HPA HPA031038
MIM 602881
neXtProt NX_O43189
PharmGKB PA33259
eggNOG NOG244542
GeneTree ENSGT00390000009222
HOVERGEN HBG004755
InParanoid O43189
KO K11467
OMA EMMETAG
PhylomeDB O43189
TreeFam TF106420
Reactome REACT_200808
ChiTaRS PHF1
EvolutionaryTrace O43189
GeneWiki PHF1
GenomeRNAi 5252
NextBio 20290
PRO PR:O43189
Proteomes UP000005640
UP000005640
Bgee O43189
CleanEx HS_PHF1
ExpressionAtlas O43189
Genevestigator O43189
GO GO:0005737
GO:0005815
GO:0005634
GO:0035861
GO:0035064
GO:0003700
GO:0008270
GO:0006974
GO:0016568
GO:0061086
GO:0061087
GO:0006351
Gene3D 3.30.40.10
InterPro IPR025894
IPR002999
IPR019786
IPR011011
IPR001965
IPR019787
IPR013083
Pfam PF14061
PF00628
SMART SM00249
SM00333
SUPFAM SSF57903
PROSITE PS01359
PS50016

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001867

complement activation, lectin pathway

PMID:23150668[1]

ECO:0000314

P

FIGURE #1 shows that "PHF1 specifically activates p53 pathway" therefore regulating cell growth and apoptosis.

complete
CACAO 6008

colocalizes_with

GO:0005813

centrosome

PMID:20873783[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061087

positive regulation of histone H3-K27 methylation

PMID:23273982[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061086

negative regulation of histone H3-K27 methylation

PMID:23142980[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:23142980[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0035098

ESC/E(Z) complex

PMID:23273982[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

PMID:23273982[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

PMID:23142980[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:23142980[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23273982[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061087

positive regulation of histone H3-K27 methylation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105050
MGI:MGI:1921266
PANTHER:PTN000290238
UniProtKB:O43189
UniProtKB:Q5T6S3

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000290238
TAIR:locus:2090694
UniProtKB:P48785

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000290238
TAIR:locus:2090694
UniProtKB:P48785

F

Seeded From UniProt

complete

colocalizes_with

GO:0035098

ESC/E(Z) complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105050
MGI:MGI:1921266
PANTHER:PTN000290240
UniProtKB:O43189
UniProtKB:Q5T6S3

C

Seeded From UniProt

complete

colocalizes_with

GO:0035098

ESC/E(Z) complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105050
MGI:MGI:1921266
PANTHER:PTN000290238
UniProtKB:O43189
UniProtKB:Q5T6S3

C

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003044
MGI:MGI:105050
MGI:MGI:1921266
MGI:MGI:98647
PANTHER:PTN000290238
UniProtKB:O43189
UniProtKB:Q5T6S3
UniProtKB:Q9Y483

F

Seeded From UniProt

complete

contributes_to

GO:0031491

nucleosome binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000290238
PomBase:SPAC30D11.08c
PomBase:SPCC4G3.07c

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003044
PANTHER:PTN000290238

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XI49
ensembl:ENSRNOP00000075915

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XI49
ensembl:ENSRNOP00000075915

F

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1B8
ensembl:ENSMUSP00000073402

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031202

P

Seeded From UniProt

complete

involved_in

GO:0031060

regulation of histone methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031202

P

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031202

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9545646[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045814

negative regulation of gene expression, epigenetic

Reactome:R-HSA-212300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-212263
Reactome:R-HSA-212252

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yang, Y et al. (2013) Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J. Biol. Chem. 288 529-39 PubMed GONUTS page
  2. ↑ Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Cai, L et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49 571-82 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Musselman, CA et al. (2012) Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat. Struct. Mol. Biol. 19 1266-72 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Coulson, M et al. (1998) The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster. Genomics 48 381-3 PubMed GONUTS page
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