HUMAN:SIRT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SIRT1 (synonyms: SIR2L1)
Protein Name(s)	NAD-dependent deacetylase sirtuin-1 hSIRT1 SIR2-like protein 1 hSIR2 SirtT1 75 kDa fragment 75SirT1
External Links
UniProt	Q96EB6
EMBL	AF083106 AF235040 DQ278604 AL133551 BC012499
IPI	IPI00016802
RefSeq	NP_001135970.1 NP_036370.2
UniGene	Hs.369779
ProteinModelPortal	Q96EB6
SMR	Q96EB6
DIP	DIP-29757N
IntAct	Q96EB6
STRING	Q96EB6
PhosphoSite	Q96EB6
DMDM	38258633
PeptideAtlas	Q96EB6
PRIDE	Q96EB6
Ensembl	ENST00000212015
GeneID	23411
KEGG	hsa:23411
UCSC	uc001jnd.3
CTD	23411
GeneCards	GC10P069644
H-InvDB	HIX0008867
HGNC	HGNC:14929
HPA	CAB003855 HPA006295
MIM	604479
neXtProt	NX_Q96EB6
PharmGKB	PA37935
eggNOG	COG0846
GeneTree	ENSGT00550000074996
HOGENOM	HBG403109
HOVERGEN	HBG054192
InParanoid	Q96EB6
KO	K11411
OMA	GEPLRKR
OrthoDB	EOG4RNB8G
PhylomeDB	Q96EB6
Pathway_Interaction_DB	foxopathway ar_tf_pathway hdac_classi_pathway hdac_classiii_pathway
NextBio	45603
ArrayExpress	Q96EB6
Bgee	Q96EB6
CleanEx	HS_SIRT1
Genevestigator	Q96EB6
GermOnline	ENSG00000096717
GO	GO:0005677 GO:0005739 GO:0005719 GO:0005720 GO:0005637 GO:0005730 GO:0016605 GO:0033553 GO:0043425 GO:0042393 GO:0043398 GO:0042802 GO:0051019 GO:0070403 GO:0046969 GO:0002039 GO:0008022 GO:0003714 GO:0008270 GO:0001525 GO:0007569 GO:0001678 GO:0070301 GO:0071456 GO:0071479 GO:0009267 GO:0071356 GO:0035356 GO:0042632 GO:0000183 GO:0042771 GO:0006260 GO:0000731 GO:0006343 GO:0055089 GO:0070932 GO:0044419 GO:0006344 GO:0006346 GO:0007517 GO:0060766 GO:0043066 GO:2000480 GO:0030308 GO:2000655 GO:2000773 GO:0043518 GO:0045599 GO:0051097 GO:0043124 GO:0032088 GO:2000757 GO:0042326 GO:0031393 GO:0051898 GO:0032007 GO:0000122 GO:0030512 GO:0018394 GO:0034983 GO:0002821 GO:0045768 GO:2000481 GO:0008284 GO:2000774 GO:0010875 GO:0031937 GO:0043280 GO:0045739 GO:0046628 GO:0016239 GO:2000111 GO:0045348 GO:0001934 GO:0045944 GO:0043161 GO:0031648 GO:0016567 GO:0000720 GO:0070857 GO:0032071 GO:0010906 GO:0007346 GO:0035358 GO:0033158 GO:0034391 GO:0032868 GO:0006364 GO:0000012 GO:0006351 GO:0006642 GO:0050872
InterPro	IPR003000
PANTHER	PTHR11085
Pfam	PF02146
PROSITE	PS50305

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042493	response to drug	PMID:22363646^[1]	ECO:0000315			P		Figure 4: Knockdown of SIRT1 allows the cells to become sensitive to the drug. Data shows that SIRT1 allows the cell to be drug resistant.	complete CACAO 3938
	GO:0043066	negative regulation of apoptotic process	PMID:22363646^[1]	ECO:0000270			P		Figure 5A-C: overexpression of SIRT1 allows for the downregulation of apoptosis, allowing for ATF4-induced multi-drug resistance in gastric cancer.	complete CACAO 3939
involved_in	GO:0006476	protein deacetylation	PMID:20424141^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:23960241^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:23960241^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0007179)	Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:20424141^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(UniProtKB:Q12778) occurs_in:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:20424141^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20424141^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	PMID:30193097^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:23960241^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0002618) part_of:(GO:0007179)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:25217442^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0010934	macrophage cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:24048733^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:24043310^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07869	F		Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	PMID:20203304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544) has_regulation_target:(UniProtKB:F1S6Q9)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:20203304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544) has_regulation_target:(UniProtKB:F1S6Q9)	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20203304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071900	regulation of protein serine/threonine kinase activity	PMID:20203304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20074560^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:24824780^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20167603^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:20203304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:F1S6Q9) occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12837246^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:20670893^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	PMID:20670893^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P17861-2)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20955178^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35426-2	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P17861)	Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P17861)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:17916362^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	PMID:17916362^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090400	stress-induced premature senescence	PMID:17916362^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000619	negative regulation of histone H4-K16 acetylation	PMID:17916362^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071441	negative regulation of histone H3-K14 acetylation	PMID:17916362^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:20955178^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:18662546^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:18662546^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
enables	GO:1990254	keratin filament binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5XKE5	F		Seeded From UniProt	complete
involved_in	GO:0051574	positive regulation of histone H3-K9 methylation	PMID:22956909^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:22956909^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16401	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13492	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09874	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96PZ0	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17535	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17544	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:23382074^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05412	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:22956909^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22956909^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000655	negative regulation of cellular response to testosterone stimulus	PMID:17505061^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	PMID:17317627^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:11672522^[21]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:17505061^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	PMID:17505061^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	PMID:20027304^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11672523^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:11672523^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:17505061^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:11672523^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:12535671^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBP5	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:12535671^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14469	F		Seeded From UniProt	complete
enables	GO:0043398	HLH domain binding	PMID:12535671^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14469	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15469825^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:15469825^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10412	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:12006491^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:11672523^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031937	positive regulation of chromatin silencing	PMID:15469825^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:17505061^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:12006491^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:12006491^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:12006491^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0006642	triglyceride mobilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:11672523^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006344	maintenance of chromatin silencing	PMID:15469825^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006343	establishment of chromatin silencing	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|part_of	GO:0005737	cytoplasm	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11672523^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:12535671^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:11672523^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:17505061^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12535671^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000774	positive regulation of cellular senescence	PMID:18687677^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:20203304^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000757	negative regulation of peptidyl-lysine acetylation	PMID:20100829^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	PMID:18687677^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PMID:20203304^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000111	positive regulation of macrophage apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20620956^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:15152190^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:21149730^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051097	negative regulation of helicase activity	PMID:18203716^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	PMID:21241768^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21807113^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:19934257^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:19934257^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:21890893^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21807113^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19047049^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21841822^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:17680780^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21775285^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16892051^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:19047049^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:15152190^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:20100829^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:19934257^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:17612497^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035356	cellular triglyceride homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
colocalizes_with	GO:0035098	ESC/E(Z) complex	PMID:15684044^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:21775285^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034391	regulation of smooth muscle cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:21807113^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:19934257^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	PMID:18485871^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:15152190^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032071	regulation of endodeoxyribonuclease activity	PMID:19934257^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:20169165^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0031393	negative regulation of prostaglandin biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	PMID:18203716^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	PMID:18004385^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:16079181^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:17172643^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21841822^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:18296641^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21807113^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:18203716^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14191	F		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:15692560^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:14976264^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:18203716^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:20027304^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:18203716^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|part_of	GO:0005730	nucleolus	PMID:16079181^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005677	chromatin silencing complex	PMID:18485871^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:16079181^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:15469825^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19934257^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	PMID:21890893^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:20620956^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000731	DNA synthesis involved in DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q923E4	P		Seeded From UniProt	complete
involved_in	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	PMID:21149730^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000183	chromatin silencing at rDNA	PMID:18485871^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21947282^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15692560^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000012	single strand break repair	PMID:20097625^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 RGD:1308542 UniProtKB:Q96EB6 WB:WBGene00004800	P		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000119154 PomBase:SPBC16D10.07c UniProtKB:Q8IXJ6	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q8IXJ6 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:21873635^[54]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:18485871^[44]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:23056314^[55]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:16959573^[56]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061647	histone H3-K9 modification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:0061647	histone H3-K9 modification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:1990619	histone H3-K9 deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:1990619	histone H3-K9 deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:2000111	positive regulation of macrophage apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:1900113	negative regulation of histone H3-K9 trimethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0051152	positive regulation of smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0042595	behavioral response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0035356	cellular triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
involved_in	GO:0034391	regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0031393	negative regulation of prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0010934	macrophage cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0006642	triglyceride mobilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0001542	ovulation from ovarian follicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	C		Seeded From UniProt	complete
involved_in	GO:0000731	DNA synthesis involved in DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923E4 ensembl:ENSMUSP00000112595	P		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003000	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:28386764^[57]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:10381378^[58]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:11672523^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0006471	protein ADP-ribosylation	PMID:17456799^[59]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
NOT\|enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:17456799^[59]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006346	methylation-dependent chromatin silencing	PMID:21947282^[52]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	Reactome:R-HSA-3371467	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9620532 Reactome:R-HSA-427528 Reactome:R-HSA-427527 Reactome:R-HSA-427514 Reactome:R-HSA-3371537 Reactome:R-HSA-3371518 Reactome:R-HSA-3371467	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000183	chromatin silencing at rDNA	Reactome:R-HSA-427359	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0698	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0517	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhu, H et al. (2012) Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS ONE 7 e31431 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhao, T et al. (2010) MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am. J. Physiol. Endocrinol. Metab. 299 E110-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Volkmann, I et al. (2013) MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ. Res. 113 997-1003 PubMed GONUTS page
↑ Latorre-Muro, P et al. (2018) Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol. Cell 71 718-732.e9 PubMed GONUTS page
↑ Kumarswamy, R et al. (2014) Vascular importance of the miR-212/132 cluster. Eur. Heart J. 35 3224-31 PubMed GONUTS page
↑ Roy, A et al. (2013) Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Am. J. Physiol., Cell Physiol. 305 C1021-32 PubMed GONUTS page
↑ Laurent, G et al. (2013) SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Mol. Cell. Biol. 33 4552-61 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Zu, Y et al. (2010) SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ. Res. 106 1384-93 PubMed GONUTS page
↑ Koyama, S et al. (2010) Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. 392 357-62 PubMed GONUTS page
↑ Pangon, L et al. (2015) MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. Int. J. Cancer 136 55-64 PubMed GONUTS page
↑ Guo, X et al. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285 13223-32 PubMed GONUTS page
↑ Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Fan, W & Luo, J (2010) SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol. Cell 39 247-58 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Ota, H et al. (2007) Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J. Mol. Cell. Cardiol. 43 571-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Li, JY et al. (2012) Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS Genet. 8 e1002879 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Dai, Y et al. (2007) Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol. Endocrinol. 21 1807-21 PubMed GONUTS page
↑ Abdelmohsen, K et al. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol. Cell 25 543-57 PubMed GONUTS page
↑ Luo, J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-48 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Nasrin, N et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4 e8414 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Vaziri, H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 149-59 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Takata, T & Ishikawa, F (2003) Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301 250-7 PubMed GONUTS page
↑ ^25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 ^25.12 ^25.13 Vaquero, A et al. (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 93-105 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Langley, E et al. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21 2383-96 PubMed GONUTS page
↑ ^27.0 ^27.1 Lan, F et al. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283 27628-35 PubMed GONUTS page
↑ ^28.0 ^28.1 Wang, J & Chen, J (2010) SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J. Biol. Chem. 285 11458-64 PubMed GONUTS page
↑ ^29.0 ^29.1 Lim, JH et al. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol. Cell 38 864-78 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Yeung, F et al. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 2369-80 PubMed GONUTS page
↑ ^31.0 ^31.1 Ming, M et al. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U.S.A. 107 22623-8 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 Li, K et al. (2008) Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J. Biol. Chem. 283 7590-8 PubMed GONUTS page
↑ Fröjdö, S et al. (2011) Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Mol. Cell. Endocrinol. 335 166-76 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Mao, B et al. (2011) Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. Int. J. Biochem. Cell Biol. 43 1573-81 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Yamamori, T et al. (2010) SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 38 832-45 PubMed GONUTS page
↑ ^36.0 ^36.1 Wu, X et al. (2011) SIRT1 links CIITA deacetylation to MHC II activation. Nucleic Acids Res. 39 9549-58 PubMed GONUTS page
↑ ^37.0 ^37.1 Bourguignon, LY et al. (2009) Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J. Biol. Chem. 284 2657-71 PubMed GONUTS page
↑ ^38.0 ^38.1 Wang, F et al. (2012) Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene 31 1546-57 PubMed GONUTS page
↑ Ghosh, HS et al. (2007) Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem. J. 408 105-11 PubMed GONUTS page
↑ ^40.0 ^40.1 Sundaresan, NR et al. (2011) The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal 4 ra46 PubMed GONUTS page
↑ Wang, C et al. (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8 1025-31 PubMed GONUTS page
↑ Yuan, Z et al. (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 149-62 PubMed GONUTS page
↑ Kuzmichev, A et al. (2005) Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc. Natl. Acad. Sci. U.S.A. 102 1859-64 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 Murayama, A et al. (2008) Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133 627-39 PubMed GONUTS page
↑ Ghosh, HS et al. (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5 e9199 PubMed GONUTS page
↑ Vaquero, A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450 440-4 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 Michishita, E et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 4623-35 PubMed GONUTS page
↑ Shimazu, T et al. (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J. Biol. Chem. 282 4470-8 PubMed GONUTS page
↑ Lee, IH et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 3374-9 PubMed GONUTS page
↑ ^50.0 ^50.1 Yang, Y et al. (2005) Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 24 1021-32 PubMed GONUTS page
↑ Brunet, A et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-5 PubMed GONUTS page
↑ ^52.0 ^52.1 Peng, L et al. (2011) SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol. Cell. Biol. 31 4720-34 PubMed GONUTS page
↑ Uhl, M et al. (2010) Role of SIRT1 in homologous recombination. DNA Repair (Amst.) 9 383-93 PubMed GONUTS page
↑ ^54.00 ^54.01 ^54.02 ^54.03 ^54.04 ^54.05 ^54.06 ^54.07 ^54.08 ^54.09 ^54.10 ^54.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Miyashita, H et al. (2012) Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE 7 e46459 PubMed GONUTS page
↑ Haigis, MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-54 PubMed GONUTS page
↑ Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ Frye, RA (1999) Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260 273-9 PubMed GONUTS page
↑ ^59.0 ^59.1 Yamamoto, H et al. (2007) Sirtuin functions in health and disease. Mol. Endocrinol. 21 1745-55 PubMed GONUTS page

[PMID:22363646-1] 1.0 ^1.1 Zhu, H et al. (2012) Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS ONE 7 e31431 PubMed GONUTS page

[PMID:20424141-2] 2.0 ^2.1 ^2.2 ^2.3 Zhao, T et al. (2010) MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am. J. Physiol. Endocrinol. Metab. 299 E110-6 PubMed GONUTS page

[PMID:23960241-3] 3.0 ^3.1 ^3.2 Volkmann, I et al. (2013) MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ. Res. 113 997-1003 PubMed GONUTS page

[PMID:30193097-4] Latorre-Muro, P et al. (2018) Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol. Cell 71 718-732.e9 PubMed GONUTS page

[PMID:25217442-5] Kumarswamy, R et al. (2014) Vascular importance of the miR-212/132 cluster. Eur. Heart J. 35 3224-31 PubMed GONUTS page

[PMID:24048733-6] Roy, A et al. (2013) Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Am. J. Physiol., Cell Physiol. 305 C1021-32 PubMed GONUTS page

[PMID:24043310-7] Laurent, G et al. (2013) SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Mol. Cell. Biol. 33 4552-61 PubMed GONUTS page

[PMID:20203304-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Zu, Y et al. (2010) SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ. Res. 106 1384-93 PubMed GONUTS page

[PMID:20074560-9] Koyama, S et al. (2010) Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. 392 357-62 PubMed GONUTS page

[PMID:24824780-10] Pangon, L et al. (2015) MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. Int. J. Cancer 136 55-64 PubMed GONUTS page

[PMID:20167603-11] Guo, X et al. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285 13223-32 PubMed GONUTS page

[PMID:12837246-12] Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page

[PMID:20670893-13] 13.0 ^13.1 Fan, W & Luo, J (2010) SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol. Cell 39 247-58 PubMed GONUTS page

[PMID:20955178-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page

[PMID:17916362-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Ota, H et al. (2007) Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J. Mol. Cell. Cardiol. 43 571-9 PubMed GONUTS page

[PMID:18662546-16] 16.0 ^16.1 Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page

[PMID:23382074-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page

[PMID:22956909-18] 18.0 ^18.1 ^18.2 ^18.3 Li, JY et al. (2012) Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS Genet. 8 e1002879 PubMed GONUTS page

[PMID:17505061-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Dai, Y et al. (2007) Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol. Endocrinol. 21 1807-21 PubMed GONUTS page

[PMID:17317627-20] Abdelmohsen, K et al. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol. Cell 25 543-57 PubMed GONUTS page

[PMID:11672522-21] Luo, J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-48 PubMed GONUTS page

[PMID:20027304-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Nasrin, N et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4 e8414 PubMed GONUTS page

[PMID:11672523-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Vaziri, H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 149-59 PubMed GONUTS page

[PMID:12535671-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Takata, T & Ishikawa, F (2003) Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301 250-7 PubMed GONUTS page

[PMID:15469825-25] 25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 ^25.12 ^25.13 Vaquero, A et al. (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 93-105 PubMed GONUTS page

[PMID:12006491-26] 26.0 ^26.1 ^26.2 ^26.3 Langley, E et al. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21 2383-96 PubMed GONUTS page

[PMID:18687677-27] 27.0 ^27.1 Lan, F et al. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283 27628-35 PubMed GONUTS page

[PMID:20100829-28] 28.0 ^28.1 Wang, J & Chen, J (2010) SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J. Biol. Chem. 285 11458-64 PubMed GONUTS page

[PMID:20620956-29] 29.0 ^29.1 Lim, JH et al. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol. Cell 38 864-78 PubMed GONUTS page

[PMID:15152190-30] 30.0 ^30.1 ^30.2 Yeung, F et al. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 2369-80 PubMed GONUTS page

[PMID:21149730-31] 31.0 ^31.1 Ming, M et al. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U.S.A. 107 22623-8 PubMed GONUTS page

[PMID:18203716-32] 32.0 ^32.1 ^32.2 ^32.3 ^32.4 Li, K et al. (2008) Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J. Biol. Chem. 283 7590-8 PubMed GONUTS page

[PMID:21241768-33] Fröjdö, S et al. (2011) Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Mol. Cell. Endocrinol. 335 166-76 PubMed GONUTS page

[PMID:21807113-34] 34.0 ^34.1 ^34.2 ^34.3 Mao, B et al. (2011) Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. Int. J. Biochem. Cell Biol. 43 1573-81 PubMed GONUTS page

[PMID:19934257-35] 35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Yamamori, T et al. (2010) SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 38 832-45 PubMed GONUTS page

[PMID:21890893-36] 36.0 ^36.1 Wu, X et al. (2011) SIRT1 links CIITA deacetylation to MHC II activation. Nucleic Acids Res. 39 9549-58 PubMed GONUTS page

[PMID:19047049-37] 37.0 ^37.1 Bourguignon, LY et al. (2009) Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J. Biol. Chem. 284 2657-71 PubMed GONUTS page

[PMID:21841822-38] 38.0 ^38.1 Wang, F et al. (2012) Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene 31 1546-57 PubMed GONUTS page

[PMID:17680780-39] Ghosh, HS et al. (2007) Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem. J. 408 105-11 PubMed GONUTS page

[PMID:21775285-40] 40.0 ^40.1 Sundaresan, NR et al. (2011) The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal 4 ra46 PubMed GONUTS page

[PMID:16892051-41] Wang, C et al. (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8 1025-31 PubMed GONUTS page

[PMID:17612497-42] Yuan, Z et al. (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 149-62 PubMed GONUTS page

[PMID:15684044-43] Kuzmichev, A et al. (2005) Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc. Natl. Acad. Sci. U.S.A. 102 1859-64 PubMed GONUTS page

[PMID:18485871-44] 44.0 ^44.1 ^44.2 ^44.3 Murayama, A et al. (2008) Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133 627-39 PubMed GONUTS page

[PMID:20169165-45] Ghosh, HS et al. (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5 e9199 PubMed GONUTS page

[PMID:18004385-46] Vaquero, A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450 440-4 PubMed GONUTS page

[PMID:16079181-47] 47.0 ^47.1 ^47.2 Michishita, E et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 4623-35 PubMed GONUTS page

[PMID:17172643-48] Shimazu, T et al. (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J. Biol. Chem. 282 4470-8 PubMed GONUTS page

[PMID:18296641-49] Lee, IH et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 3374-9 PubMed GONUTS page

[PMID:15692560-50] 50.0 ^50.1 Yang, Y et al. (2005) Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 24 1021-32 PubMed GONUTS page

[PMID:14976264-51] Brunet, A et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-5 PubMed GONUTS page

[PMID:21947282-52] 52.0 ^52.1 Peng, L et al. (2011) SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol. Cell. Biol. 31 4720-34 PubMed GONUTS page

[PMID:20097625-53] Uhl, M et al. (2010) Role of SIRT1 in homologous recombination. DNA Repair (Amst.) 9 383-93 PubMed GONUTS page

[PMID:21873635-54] 54.00 ^54.01 ^54.02 ^54.03 ^54.04 ^54.05 ^54.06 ^54.07 ^54.08 ^54.09 ^54.10 ^54.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23056314-55] Miyashita, H et al. (2012) Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE 7 e46459 PubMed GONUTS page

[PMID:16959573-56] Haigis, MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-54 PubMed GONUTS page

[PMID:28386764-57] Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:10381378-58] Frye, RA (1999) Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260 273-9 PubMed GONUTS page

[PMID:17456799-59] 59.0 ^59.1 Yamamoto, H et al. (2007) Sirtuin functions in health and disease. Mol. Endocrinol. 21 1745-55 PubMed GONUTS page

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[36]

[37]

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[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

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