MOUSE:SIR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sirt1 (synonyms: Sir2l1)
Protein Name(s)	NAD-dependent protein deacetylase sirtuin-1 Regulatory protein SIR2 homolog 1 SIR2-like protein 1 SIR2alpha Sir2 mSIR2a SirtT1 75 kDa fragment 75SirT1
External Links
UniProt	Q923E4
EMBL	AF214646 BC006584
CCDS	CCDS23898.1
RefSeq	NP_062786.1
UniGene	Mm.351459
ProteinModelPortal	Q923E4
SMR	Q923E4
BioGrid	220297
DIP	DIP-47052N
IntAct	Q923E4
PhosphoSite	Q923E4
MaxQB	Q923E4
PaxDb	Q923E4
PRIDE	Q923E4
DNASU	93759
Ensembl	ENSMUST00000020257 ENSMUST00000120239 ENSMUST00000177694
GeneID	93759
KEGG	mmu:93759
UCSC	uc007fke.2
CTD	23411
MGI	MGI:2135607
eggNOG	COG0846
GeneTree	ENSGT00740000115330
HOGENOM	HOG000038016
HOVERGEN	HBG054192
InParanoid	Q923E4
KO	K11411
OMA	NYPSNKS
OrthoDB	EOG7WX09C
PhylomeDB	Q923E4
Reactome	REACT_222185 REACT_224328
NextBio	351639
PRO	PR:Q923E4
Proteomes	UP000000589
Bgee	Q923E4
ExpressionAtlas	Q923E4
Genevestigator	Q923E4
GO	GO:0000785 GO:0005737 GO:0005739 GO:0005719 GO:0005720 GO:0005637 GO:0005654 GO:0005634 GO:0016605 GO:0043425 GO:0001046 GO:0019213 GO:0019899 GO:0046872 GO:0070403 GO:0017136 GO:0046969 GO:0034979 GO:0002039 GO:0033558 GO:0019904 GO:0003714 GO:0001525 GO:0042595 GO:0001678 GO:0071456 GO:0071479 GO:0009267 GO:0071356 GO:0035356 GO:0042632 GO:0032922 GO:0007623 GO:0000731 GO:0055089 GO:0016575 GO:0070932 GO:0061647 GO:0008630 GO:0042771 GO:0007517 GO:0043066 GO:2000480 GO:2000773 GO:0045599 GO:0043124 GO:1902166 GO:1901215 GO:0032088 GO:2000757 GO:0042326 GO:0031393 GO:0051898 GO:0032007 GO:0000122 GO:0045892 GO:0030512 GO:0001542 GO:0002821 GO:0043065 GO:2000481 GO:0008284 GO:2000774 GO:0010875 GO:0045739 GO:0046628 GO:0016239 GO:2000111 GO:0001934 GO:0045944 GO:0043161 GO:0006476 GO:0031648 GO:0016567 GO:0000720 GO:0070857 GO:0032071 GO:0010906 GO:0007346 GO:0035358 GO:0034391 GO:0042542 GO:0032868 GO:0006364 GO:0000012 GO:0007283 GO:0006351 GO:0006642 GO:0050872
Gene3D	3.30.1600.10 3.40.50.1220
InterPro	IPR029035 IPR003000 IPR026591 IPR026590
PANTHER	PTHR11085
Pfam	PF02146
SUPFAM	SSF52467
PROSITE	PS50305

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1900113	negative regulation of histone H3-K9 trimethylation	PMID:25526086^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(ENSEMBL:ENSMUSG00000035783)\|has_direct_input:(ENSEMBL:ENSMUSG00000032085)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:25526086^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000035783) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000032085) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000015605) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000005583) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000020542) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25526086^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000035783)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000032085)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000015605)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000005583)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000020542)	Seeded From UniProt	complete
involved_in	GO:0051152	positive regulation of smooth muscle cell differentiation	PMID:25526086^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	PMID:22315447^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	PMID:22315447^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:22315447^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010934	macrophage cytokine production	PMID:22315447^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	PMID:22315447^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:20620997^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:20167603^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:20167603^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	PMID:20620997^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:20620997^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	PMID:20620997^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:20955178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O35426)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20955178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:20955178^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:18662546^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:18662546^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18662546^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:18662546^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:19299583^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:19299583^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:24089055^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:11672522^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:11672523^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:15175761^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60974	F		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006642	triglyceride mobilization	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:19470756^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)\|has_direct_input(UniProtKB:P11103)	Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:11672523^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19470756^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19470756^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:15175761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:11672522^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19470756^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000774	positive regulation of cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	PMID:18687677^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:2000111	positive regulation of macrophage apoptotic process	PMID:20042607^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:17612497^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	PMID:20375098^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	PMID:17347648^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:21149730^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	PMID:20972425^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15220471^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:17936707^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:17612497^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035356	cellular triglyceride homeostasis	PMID:17936707^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0035098	ESC/E(Z) complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:15220471^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034391	regulation of smooth muscle cell apoptotic process	PMID:17098745^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:17521387^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:19578370^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:17901049^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0032071	regulation of endodeoxyribonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:20169165^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:17936707^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031393	negative regulation of prostaglandin biosynthetic process	PMID:20042607^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:17098745^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20972425^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04797	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19578370^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91YE5	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	PMID:18004385^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:20972425^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:18296641^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:21189328^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	PMID:17347648^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:17936707^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:16269335^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:17521387^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17521387^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17197703^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:18004385^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18004385^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:17901049^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:15744310^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16269335^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000731	DNA synthesis involved in DNA repair	PMID:17612497^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	PMID:21149730^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0000012	single strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 RGD:1308542 UniProtKB:Q96EB6 WB:WBGene00004800	P		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000119154 PomBase:SPBC16D10.07c UniProtKB:Q8IXJ6	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q8IXJ6 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000872223 UniProtKB:Q96EB6	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135607 PANTHER:PTN000872223 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	PMID:11250901^[34]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000774	positive regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000773	negative regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000655	negative regulation of cellular response to testosterone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000619	negative regulation of histone H4-K16 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000614	positive regulation of thyroid-stimulating hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000270	negative regulation of fibroblast apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990254	keratin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901984	negative regulation of protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901984	negative regulation of protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	PMID:22956852^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900181	negative regulation of protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097009	energy homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090400	stress-induced premature senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090312	positive regulation of protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071900	regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071441	negative regulation of histone H3-K14 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070932	histone H3 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070932	histone H3 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070914	UV-damage excision repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060125	negative regulation of growth hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051574	positive regulation of histone H3-K9 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051097	negative regulation of helicase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15381699^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045739	positive regulation of DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	F		Seeded From UniProt	complete
enables	GO:0043398	HLH domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043392	negative regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042595	behavioral response to starvation	PMID:20668205^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677369	P	has_participant:(EMAPA:35417)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042326	negative regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
colocalizes_with	GO:0035098	ESC/E(Z) complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:23056314^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032922	circadian regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032071	regulation of endodeoxyribonuclease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032007	negative regulation of TOR signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031937	positive regulation of chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:10693811^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:16959573^[41]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	PMID:23160044^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107187	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	PMID:10693811^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016239	positive regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014858	positive regulation of skeletal muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010460	positive regulation of heart rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:12482959^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006344	maintenance of chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006343	establishment of chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006325	chromatin organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26767982^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005677	chromatin silencing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15381699^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12482959^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000349)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308542	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002821	positive regulation of adaptive immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001542	ovulation from ovarian follicle	PMID:12482959^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000183	chromatin silencing at rDNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000012	single strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96EB6	P		Seeded From UniProt	complete
involved_in	GO:0061647	histone H3-K9 modification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:1990619	histone H3-K9 deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046969	P		Seeded From UniProt	complete
involved_in	GO:2000774	positive regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000655	negative regulation of cellular response to testosterone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000619	negative regulation of histone H4-K16 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:1990254	keratin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0090400	stress-induced premature senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0071900	regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0071441	negative regulation of histone H3-K14 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0051574	positive regulation of histone H3-K9 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0051097	negative regulation of helicase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
enables	GO:0043398	HLH domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
part_of	GO:0035098	ESC/E(Z) complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0032071	regulation of endodeoxyribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0031937	positive regulation of chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006344	maintenance of chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006343	establishment of chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005677	chromatin silencing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
involved_in	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0000183	chromatin silencing at rDNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
involved_in	GO:0000012	single strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96EB6 ensembl:ENSP00000212015	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024QZQ1 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024QZQ1 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024QZQ1 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024QZQ1 ensembl:ENSP00000212015	C		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003000	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9626966 Reactome:R-MMU-5211233	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0517	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0698	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yu, X et al. (2015) Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death Differ. 22 1170-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xu, F et al. (2012) Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology 153 1706-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ramadori, G et al. (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 12 78-87 PubMed GONUTS page
↑ ^4.0 ^4.1 Guo, X et al. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285 13223-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page
↑ ^7.0 ^7.1 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page
↑ Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page
↑ ^9.0 ^9.1 Luo, J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-48 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Picard, F et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 771-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Vaziri, H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 149-59 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Rajamohan, SB et al. (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell. Biol. 29 4116-29 PubMed GONUTS page
↑ Lan, F et al. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283 27628-35 PubMed GONUTS page
↑ ^14.0 ^14.1 Zhang, R et al. (2010) SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 285 7097-110 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Yuan, Z et al. (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 149-62 PubMed GONUTS page
↑ Chanda, D et al. (2010) Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res. 38 4607-19 PubMed GONUTS page
↑ ^17.0 ^17.1 Gerhart-Hines, Z et al. (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26 1913-23 PubMed GONUTS page
↑ ^18.0 ^18.1 Ming, M et al. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U.S.A. 107 22623-8 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Kornberg, MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12 1094-100 PubMed GONUTS page
↑ ^20.0 ^20.1 Daitoku, H et al. (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. U.S.A. 101 10042-7 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Li, X et al. (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28 91-106 PubMed GONUTS page
↑ ^22.0 ^22.1 Kume, S et al. (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282 151-8 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Wang, F et al. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6 505-14 PubMed GONUTS page
↑ ^24.0 ^24.1 Zhou, Y et al. (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat. Cell Biol. 11 1010-6 PubMed GONUTS page
↑ ^25.0 ^25.1 Zhang, J (2007) The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282 34356-64 PubMed GONUTS page
↑ Ghosh, HS et al. (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5 e9199 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Vaquero, A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450 440-4 PubMed GONUTS page
↑ Lee, IH et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 3374-9 PubMed GONUTS page
↑ Powell, MJ et al. (2011) Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 71 964-75 PubMed GONUTS page
↑ ^30.0 ^30.1 Chen, WY et al. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 437-48 PubMed GONUTS page
↑ Tanno, M et al. (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282 6823-32 PubMed GONUTS page
↑ Rodgers, JT et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 113-8 PubMed GONUTS page
↑ ^33.00 ^33.01 ^33.02 ^33.03 ^33.04 ^33.05 ^33.06 ^33.07 ^33.08 ^33.09 ^33.10 ^33.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Muth, V et al. (2001) Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20 1353-62 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ Parker, JA et al. (2012) Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J. Neurosci. 32 12630-40 PubMed GONUTS page
↑ ^37.0 ^37.1 Revollo, JR et al. (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279 50754-63 PubMed GONUTS page
↑ Satoh, A et al. (2010) SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J. Neurosci. 30 10220-32 PubMed GONUTS page
↑ Miyashita, H et al. (2012) Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE 7 e46459 PubMed GONUTS page
↑ ^40.0 ^40.1 Imai, S et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 795-800 PubMed GONUTS page
↑ Haigis, MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-54 PubMed GONUTS page
↑ Tiberi, L et al. (2012) BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat. Neurosci. 15 1627-35 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 McBurney, MW et al. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23 38-54 PubMed GONUTS page
↑ Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page

[PMID:25526086-1] 1.0 ^1.1 ^1.2 ^1.3 Yu, X et al. (2015) Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death Differ. 22 1170-80 PubMed GONUTS page

[PMID:22315447-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xu, F et al. (2012) Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology 153 1706-16 PubMed GONUTS page

[PMID:20620997-3] 3.0 ^3.1 ^3.2 ^3.3 Ramadori, G et al. (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 12 78-87 PubMed GONUTS page

[PMID:20167603-4] 4.0 ^4.1 Guo, X et al. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285 13223-32 PubMed GONUTS page

[PMID:20955178-5] 5.0 ^5.1 ^5.2 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page

[PMID:18662546-6] 6.0 ^6.1 ^6.2 ^6.3 Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page

[PMID:19299583-7] 7.0 ^7.1 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page

[PMID:24089055-8] Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page

[PMID:11672522-9] 9.0 ^9.1 Luo, J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-48 PubMed GONUTS page

[PMID:15175761-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Picard, F et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 771-6 PubMed GONUTS page

[PMID:11672523-11] 11.0 ^11.1 Vaziri, H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 149-59 PubMed GONUTS page

[PMID:19470756-12] 12.0 ^12.1 ^12.2 ^12.3 Rajamohan, SB et al. (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell. Biol. 29 4116-29 PubMed GONUTS page

[PMID:18687677-13] Lan, F et al. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283 27628-35 PubMed GONUTS page

[PMID:20042607-14] 14.0 ^14.1 Zhang, R et al. (2010) SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 285 7097-110 PubMed GONUTS page

[PMID:17612497-15] 15.0 ^15.1 ^15.2 Yuan, Z et al. (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 149-62 PubMed GONUTS page

[PMID:20375098-16] Chanda, D et al. (2010) Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res. 38 4607-19 PubMed GONUTS page

[PMID:17347648-17] 17.0 ^17.1 Gerhart-Hines, Z et al. (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26 1913-23 PubMed GONUTS page

[PMID:21149730-18] 18.0 ^18.1 Ming, M et al. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. U.S.A. 107 22623-8 PubMed GONUTS page

[PMID:20972425-19] 19.0 ^19.1 ^19.2 Kornberg, MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12 1094-100 PubMed GONUTS page

[PMID:15220471-20] 20.0 ^20.1 Daitoku, H et al. (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. U.S.A. 101 10042-7 PubMed GONUTS page

[PMID:17936707-21] 21.0 ^21.1 ^21.2 ^21.3 Li, X et al. (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28 91-106 PubMed GONUTS page

[PMID:17098745-22] 22.0 ^22.1 Kume, S et al. (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282 151-8 PubMed GONUTS page

[PMID:17521387-23] 23.0 ^23.1 ^23.2 Wang, F et al. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6 505-14 PubMed GONUTS page

[PMID:19578370-24] 24.0 ^24.1 Zhou, Y et al. (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat. Cell Biol. 11 1010-6 PubMed GONUTS page

[PMID:17901049-25] 25.0 ^25.1 Zhang, J (2007) The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282 34356-64 PubMed GONUTS page

[PMID:20169165-26] Ghosh, HS et al. (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5 e9199 PubMed GONUTS page

[PMID:18004385-27] 27.0 ^27.1 ^27.2 Vaquero, A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450 440-4 PubMed GONUTS page

[PMID:18296641-28] Lee, IH et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 3374-9 PubMed GONUTS page

[PMID:21189328-29] Powell, MJ et al. (2011) Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 71 964-75 PubMed GONUTS page

[PMID:16269335-30] 30.0 ^30.1 Chen, WY et al. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 437-48 PubMed GONUTS page

[PMID:17197703-31] Tanno, M et al. (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282 6823-32 PubMed GONUTS page

[PMID:15744310-32] Rodgers, JT et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 113-8 PubMed GONUTS page

[PMID:21873635-33] 33.00 ^33.01 ^33.02 ^33.03 ^33.04 ^33.05 ^33.06 ^33.07 ^33.08 ^33.09 ^33.10 ^33.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11250901-34] Muth, V et al. (2001) Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20 1353-62 PubMed GONUTS page

[PMID:20439489-35] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:22956852-36] Parker, JA et al. (2012) Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J. Neurosci. 32 12630-40 PubMed GONUTS page

[PMID:15381699-37] 37.0 ^37.1 Revollo, JR et al. (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279 50754-63 PubMed GONUTS page

[PMID:20668205-38] Satoh, A et al. (2010) SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J. Neurosci. 30 10220-32 PubMed GONUTS page

[PMID:23056314-39] Miyashita, H et al. (2012) Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE 7 e46459 PubMed GONUTS page

[PMID:10693811-40] 40.0 ^40.1 Imai, S et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 795-800 PubMed GONUTS page

[PMID:16959573-41] Haigis, MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-54 PubMed GONUTS page

[PMID:23160044-42] Tiberi, L et al. (2012) BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat. Neurosci. 15 1627-35 PubMed GONUTS page

[PMID:12482959-43] 43.0 ^43.1 ^43.2 McBurney, MW et al. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23 38-54 PubMed GONUTS page

[PMID:26767982-44] Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page

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