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DROME:O46034

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: cbl (ECO:0000313 with EMBL:CAA11149.1))
Protein Name(s) CG7037-PA, isoform A (ECO:0000313 with EMBL:AAF50417.1)

Cbl protein (ECO:0000313 with EMBL:CAA11149.1) LD46082p (ECO:0000313 with EMBL:AAM49962.1)

External Links
UniProt O46034
EMBL AE003555
AY118593
AJ223175
RefSeq NP_729382.1
UniGene Dm.2332
SMR O46034
MINT MINT-312379
EnsemblMetazoa FBtr0076614
GeneID 38961
KEGG dme:Dmel_CG7037
UCSC CG7037-RA
CTD 867
FlyBase FBgn0020224
eggNOG NOG242251
GeneTree ENSGT00390000011617
KO K04707
OrthoDB EOG7M0NQX
Reactome REACT_180238
REACT_180240
REACT_180243
REACT_250163
REACT_261064
REACT_262116
GenomeRNAi 38961
NextBio 811201
Proteomes UP000000803
GO GO:0005938
GO:0005737
GO:0005634
GO:0005509
GO:0016874
GO:0001784
GO:0030971
GO:0004871
GO:0004842
GO:0008270
GO:0007298
GO:0009950
GO:0008069
GO:0006897
GO:0007173
GO:0001754
GO:0048134
GO:0007476
GO:0042059
GO:0007175
GO:0032353
GO:0006508
GO:0007465
GO:0006109
GO:0010941
GO:0042127
Gene3D 1.10.238.10
1.20.930.20
3.30.40.10
3.30.505.10
InterPro IPR024162
IPR014741
IPR003153
IPR014742
IPR024159
IPR011992
IPR000980
IPR001841
IPR013083
IPR017907
PANTHER PTHR23007
Pfam PF02262
PF02761
PF02762
SMART SM00184
SUPFAM SSF47668
SSF55550
PROSITE PS51506
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0055131

C3HC4-type RING finger domain binding

PMID:21340027[1]

IDA: Inferred from Direct Assay

F

Table 3 Figure 4

complete

GO:0001754

eye photoreceptor cell differentiation

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

F

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

F

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

F

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011992

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

C

complete

GO:0005938

cell cortex

PMID:16844358[3]

IDA: Inferred from Direct Assay

C

complete

GO:0006508

proteolysis

PMID:14570584[4]

TAS: Traceable Author Statement

P

complete

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

P

complete

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

P

complete

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

P

complete

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:11287200[5]

TAS: Traceable Author Statement

P

complete

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:12648473[7]

TAS: Traceable Author Statement

P

complete

GO:0007298

border follicle cell migration

PMID:16054027[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007465

R7 cell fate commitment

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008069

dorsal/ventral axis specification, ovarian follicular epithelium

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

complete

GO:0009950

dorsal/ventral axis specification

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010941

regulation of cell death

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

complete

GO:0016874

ligase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

complete

GO:0016874

ligase activity

PMID:14570584[4]

TAS: Traceable Author Statement

F

complete

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

PMID:16844358[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042127

regulation of cell proliferation

PMID:19306863[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

complete

GO:0048134

germ-line cyst formation

PMID:19306863[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

complete

GO:0001754

eye photoreceptor cell differentiation

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0001784

phosphotyrosine binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024159

F

Seeded From UniProt

complete

GO:0001784

phosphotyrosine binding

PMID:9178769[11]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024162

F

Seeded From UniProt

complete

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

HGNC:15961

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

F

Seeded From UniProt

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21340027[1]

IPI: Inferred from Physical Interaction

FB:FBgn0004638

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:9178769[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:16844358[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006109

regulation of carbohydrate metabolic process

PMID:22778134[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006508

proteolysis

PMID:14570584[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006897

endocytosis

PMID:16054027[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

P

Seeded From UniProt

complete

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:11287200[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

PMID:12648473[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

PMID:21340027[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0004638

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:16054027[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007465

R7 cell fate commitment

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008069

dorsal/ventral axis specification, ovarian follicular epithelium

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

PMID:21912646[13]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0009950

dorsal/ventral axis specification

PMID:11051547[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010941

regulation of cell death

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016874

ligase activity

PMID:14570584[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0023051

regulation of signaling

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024162

P

Seeded From UniProt

complete

GO:0030971

receptor tyrosine kinase binding

PMID:16054027[8]

IPI: Inferred from Physical Interaction

FB:FBgn0003731
FB:FBgn0032006

F

Seeded From UniProt

complete

GO:0032353

negative regulation of hormone biosynthetic process

PMID:22778134[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

PMID:11369216[14]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

PMID:16844358[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:19306863[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

Seeded From UniProt

complete

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

HGNC:15961

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048134

germ-line cyst formation

PMID:19306863[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Wang, PY & Pai, LM (2011) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS ONE 6 e17097 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Wang, Y et al. (2008) Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS ONE 3 e1447 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Pai, LM et al. (2006) Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech. Dev. 123 450-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Ghabrial, A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu. Rev. Cell Dev. Biol. 19 623-47 PubMed GONUTS page
  5. 5.0 5.1 Hime, GR et al. (2001) Dynamic expression of alternate splice forms of D-cbl during embryogenesis. Mech. Dev. 102 235-8 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Pai, LM et al. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell 103 51-61 PubMed GONUTS page
  7. 7.0 7.1 Shilo, BZ (2003) Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp. Cell Res. 284 140-9 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Jékely, G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9 197-207 PubMed GONUTS page
  9. 9.0 9.1 Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Epstein, AM et al. (2009) Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev. Biol. 330 83-92 PubMed GONUTS page
  11. 11.0 11.1 Hime, GR et al. (1997) D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene 14 2709-19 PubMed GONUTS page
  12. 12.0 12.1 Yu, Y et al. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol. Cell. Biol. 32 3610-23 PubMed GONUTS page
  13. Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
  14. Bogdan, S & Klämbt, C (2001) Epidermal growth factor receptor signaling. Curr. Biol. 11 R292-5 PubMed GONUTS page